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The map label for this gene is dltA

Identifier: 15675261

GI number: 15675261

Start: 1089264

End: 1090802

Strand: Reverse

Name: dltA

Synonym: SPy_1312

Alternate gene names: 15675261

Gene position: 1090802-1089264 (Counterclockwise)

Preceding gene: 15675262

Following gene: 15675260

Centisome position: 58.88

GC content: 40.22

Gene sequence:

>1539_bases
ATGATTAAGGATATGATTGACAGTATTGAGCAGTTTGCTCAGACACAGGCTGATTTTCCAGTTTATGATTGTTTAGGGGA
ACGCCGCACTTACGGACAACTCAAAAGAGATTCTGATAGCATTGCTGCATTTATAGATAGCTTAGCTTTACTGGCAAAAT
CTCCAGTTTTGGTTTTTGGGGCGCAAACTTATGATATGTTAGCTACTTTTGTAGCTTTAACCAAATCTGGTCATGCCTAT
ATCCCAGTAGATGTGCATTCAGCACCAGAACGTATTTTAGCGATTATTGAGATTGCAAAGCCCAGTTTAATCATTGCTAT
TGAGGAATTCCCTCTTACTATTGAAGGGATTTCCCTTGTCTCACTATCAGAGATTGAGTCAGCAAAATTAGCAGAAATGC
CCTATGAGCGAACACATTCTGTTAAAGGAGATGATAATTATTACATTATTTTCACCTCTGGAACAACGGGCCAACCAAAA
GGGGTGCAAATTTCACATGACAATCTTTTGAGCTTTACCAACTGGATGATCGAAGATGCAGCATTTGATGTACCTAAACA
GCCACAAATGCTGGCGCAGCCACCCTATTCCTTTGACCTTTCTGTCATGTACTGGGCACCTACCTTGGCTTTAGGTGGAA
CCTTATTTGCACTTCCAAAAGAATTGGTGGCAGACTTTAAACAGTTATTTACAACGATTGCGCAACTTCCAGTTGGCATT
TGGACATCGACTCCTTCATTTGCTGATATGGCCATGCTTAGCGATGATTTTTGCCAGGCTAAGATGCCAGCTTTAACGCA
TTTTTATTTTGATGGCGAAGAATTAACCGTTTCTACGGCTCGAAAACTCTTTGAACGTTTCCCGAGTGCCAAGATTATCA
ATGCCTATGGACCAACAGAAGCGACTGTAGCCTTATCCGCTATTGAAATTACCAGAGAAATGGTGGATAATTATACCCGC
TTGCCGATTGGCTACCCCAAACCAGATTCTCCGACCTATATTATTGATGAAGATGGTAAGGAGTTATCTTCAGGGGAGCA
GGGTGAAATTATTGTTACAGGGCCTGCTGTGTCAAAAGGTTACCTCAACAATCCTGAGAAAACCGCAGAAGCTTTCTTTA
CTTTTAAAGGACAGCCTGCTTATCATACAGGGGACATTGGCTCACTGACAGAAGATAATATTTTGTTGTATGGTGGGCGT
TTGGATTTTCAGATTAAATATGCTGGTTATCGTATTGAACTAGAAGATGTTTCCCAACAGTTGAATCAATCACCAATGGT
AGCATCGGCTGTGGCTGTTCCAAGGTACAATAAAGAACATAAGGTTCAAAATCTCTTGGCCTATATCGTTGTCAAAGATG
GGGTTAAAGAGCGTTTTGATAGGGAATTGGAGTTAACCAAAGCTATCAAAGCCTCTGTTAAGGATCATATGATGAGTTAT
ATGATGCCTTCTAAGTTTCTTTATCGAGATAGTCTACCATTAACTCCAAATGGTAAGATAGATATTAAAACTTTGATTAA
TGAGGTCAATAACCGATGA

Upstream 100 bases:

>100_bases
TTTTATTTTATCTGATTTTAATGTTGCTGGTCTATTTCTTTGGTTATCTAGGACATGGTCAAAGTAACTTTATTTATAAT
GAATTTTAGGAGATTGACTG

Downstream 100 bases:

>100_bases
TGATGTTTTTTAGCCACATTCCCTACATGGAACCTTACGGTAACCCCATTTACTTTGTCTATCTTATTTTGGCTTTCTTA
CCAGTCATCATTGGGATTTT

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAY
IPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPK
GVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTR
LPIGYPKPDSPTYIIDEDGKELSSGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGR
LDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR

Sequences:

>Translated_512_residues
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAY
IPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPK
GVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTR
LPIGYPKPDSPTYIIDEDGKELSSGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGR
LDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
>Mature_512_residues
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAY
IPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPK
GVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTR
LPIGYPKPDSPTYIIDEDGKELSSGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGR
LDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily

Homologues:

Organism=Homo sapiens, GI115511026, Length=467, Percent_Identity=25.6959314775161, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI42544132, Length=460, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI187761345, Length=478, Percent_Identity=23.4309623430962, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI187761343, Length=478, Percent_Identity=23.4309623430962, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI45580730, Length=371, Percent_Identity=25.3369272237197, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI156151445, Length=525, Percent_Identity=23.6190476190476, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI38505220, Length=395, Percent_Identity=25.3164556962025, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI58082049, Length=470, Percent_Identity=24.6808510638298, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI157311624, Length=477, Percent_Identity=23.6897274633124, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI157311622, Length=477, Percent_Identity=23.6897274633124, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786801, Length=449, Percent_Identity=28.2850779510022, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786810, Length=527, Percent_Identity=23.5294117647059, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788107, Length=578, Percent_Identity=21.7993079584775, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693145, Length=402, Percent_Identity=25.1243781094527, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI221142682, Length=518, Percent_Identity=22.7799227799228, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17556356, Length=495, Percent_Identity=25.6565656565657, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=426, Percent_Identity=26.9953051643192, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=363, Percent_Identity=24.2424242424242, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71994690, Length=363, Percent_Identity=24.2424242424242, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71994703, Length=363, Percent_Identity=24.2424242424242, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319591, Length=593, Percent_Identity=25.1264755480607, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319699, Length=376, Percent_Identity=25.7978723404255, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24648676, Length=459, Percent_Identity=27.2331154684096, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI161076582, Length=371, Percent_Identity=26.1455525606469, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653035, Length=372, Percent_Identity=26.6129032258064, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355181, Length=463, Percent_Identity=23.7580993520518, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI18859661, Length=363, Percent_Identity=23.9669421487603, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356947, Length=370, Percent_Identity=24.3243243243243, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI20130357, Length=429, Percent_Identity=23.3100233100233, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648257, Length=473, Percent_Identity=24.7357293868922, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648260, Length=443, Percent_Identity=21.8961625282167, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DLTA_STRP1 (Q99ZA6)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269435.1
- RefSeq:   YP_282436.1
- PDB:   3LGX
- PDBsum:   3LGX
- ProteinModelPortal:   Q99ZA6
- SMR:   Q99ZA6
- EnsemblBacteria:   EBSTRT00000000039
- EnsemblBacteria:   EBSTRT00000027441
- GeneID:   3571853
- GeneID:   901401
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1312
- KEGG:   spz:M5005_Spy_1073
- GeneTree:   EBGT00050000027070
- HOGENOM:   HBG320748
- OMA:   QISHANL
- ProtClustDB:   PRK04813
- BioCyc:   SPYO160490:SPY1312-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1073-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00593
- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072
- PANTHER:   PTHR11968:SF34
- TIGRFAMs:   TIGR01733
- TIGRFAMs:   TIGR01734

Pfam domain/function: PF00501 AMP-binding

EC number: =6.1.1.13

Molecular weight: Translated: 56988; Mature: 56988

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFG
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEE
AQTYDMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLV
CCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHEEHHEECCCEEEEEEECCCEEECCEEEE
SLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDA
EHHHHCHHHHHHCCHHHHCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHH
AFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
HCCCCCCCHHHCCCCCCCCEEEEEECHHHHHCCHHHHCHHHHHHHHHHHHHHHHHCCCEE
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTE
EECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECCCCCC
ATVALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKELSSGEQGEIIVTGPAVSKG
HHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCC
YLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQ
CCCCCHHHHHEEEEECCCCCCCCCCCCCCCCCCEEEECCEEEEEEEEEEEEEEHHHHHHH
LNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
HCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
HCCCHHHCCCCCCCCCCCCEEHHHHHHHHCCC
>Mature Secondary Structure
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFG
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEE
AQTYDMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLV
CCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHEEHHEECCCEEEEEEECCCEEECCEEEE
SLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDA
EHHHHCHHHHHHCCHHHHCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHH
AFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
HCCCCCCCHHHCCCCCCCCEEEEEECHHHHHCCHHHHCHHHHHHHHHHHHHHHHHCCCEE
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTE
EECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECCCCCC
ATVALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKELSSGEQGEIIVTGPAVSKG
HHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCC
YLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQ
CCCCCHHHHHEEEEECCCCCCCCCCCCCCCCCCEEEECCEEEEEEEEEEEEEEHHHHHHH
LNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
HCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
HCCCHHHCCCCCCCCCCCCEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296