Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is acoB [H]

Identifier: 15675026

GI number: 15675026

Start: 835592

End: 836590

Strand: Direct

Name: acoB [H]

Synonym: SPy_1028

Alternate gene names: 15675026

Gene position: 835592-836590 (Clockwise)

Preceding gene: 15675025

Following gene: 15675027

Centisome position: 45.11

GC content: 42.24

Gene sequence:

>999_bases
ATGTCAGAAACAAAATTAATGGCTTTGCGTGAAGCAGTCAACCTTGCTATGACTGAGGAAATGCGCAAGGACGAAAACAT
TTTCCTTATGGGAGAAGACGTAGGGGTTTACGGAGGAGACTTTGGGACTTCTGTTGGAATGATTGAAGAATTTGGCCCTA
AACGTGTTAAAGATACCCCAATTTCAGAAGCTGCTATCTCTGGTGCGGCTATTGGTGCAGCTATTACAGGACTACGTCCA
ATTGTCGACGTTACCTTCATGGATTTCCTTACCATCATGATGGACGCTATCGTGAATAATGGTGCTAAAAATAATTACAT
GTTCGGTGGAGGCCTTATTACCCCTGTAACCTTCCGTGTGGCATCAGGTTCTGGTATTGGTTCCGCTGCGCAACACTCAC
AATCTCTTGAGGCATGGTTGACTCACATTCCAGGAATCAAAGTTGTTGCTCCTGGTAATGCCAACGATGCTAAAGGCTTA
TTAAAATCAGCTATCCGTGATAATAACATTGTTCTTTTCATGGAACCAAAAGCGCTTTATGGTAAAAAAGAAGAAGTTAA
CCAAGATCCTGACTTCTATATCCCACTTGGCAAAGGTGACATCAAACGTGAAGGAACTGATTTGACAATTGTGTCATACG
GTCGTATGTTGGAGCGTGTTCTTCAAGCGGCTGAAGAAGTAGCAGCGGATGGTATTAACGTTGAAGTTGTTGACCCACGT
ACCCTCATCCCACTTGATAAAGAGTTGATTATTGAATCTGTTAAGAAAACAGGTAAATTGATGCTTGTCAACGATGCCTA
CAAGACCGGTGGATTCATTGGGGAAATTGCAACCATGATTACCGAAAGTGAAGCCTTTGATTACCTTGATCATCCAATCG
TTCGTCTTGCAAGTGAAGATGTTCCAGTACCTTATGCTCGTGTACTTGAACAAGCAATCTTACCAGATGTTGAGAAAATC
AAAGCTGCTATTGTGAAAATGGCAAACAAAGGCAACTAG

Upstream 100 bases:

>100_bases
CCAGAACTTTCAGTAGCCTTCGAAGACGTTTGGGTTGACTAAGAGCACCTTGTCAGTAAGAAGCAATCGTATTTGAATAA
TAAATGGAGAAATAAAAATG

Downstream 100 bases:

>100_bases
AAGATAAGGCAAGTGGTCCGATAAAGGCTATGTTTATCAGTAACGTCTCAGCTAAAAACTATTTTGAAAGTTTTTAGAAG
AACTGAGTTGTCTTATCCCG

Product: putative acetoin dehydrogenase (TPP-dependent) subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDTPISEAAISGAAIGAAITGLRP
IVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKVVAPGNANDAKGL
LKSAIRDNNIVLFMEPKALYGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDPR
TLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASEDVPVPYARVLEQAILPDVEKI
KAAIVKMANKGN

Sequences:

>Translated_332_residues
MSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDTPISEAAISGAAIGAAITGLRP
IVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKVVAPGNANDAKGL
LKSAIRDNNIVLFMEPKALYGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDPR
TLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASEDVPVPYARVLEQAILPDVEKI
KAAIVKMANKGN
>Mature_331_residues
SETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDTPISEAAISGAAIGAAITGLRPI
VDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKVVAPGNANDAKGLL
KSAIRDNNIVLFMEPKALYGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDPRT
LIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASEDVPVPYARVLEQAILPDVEKIK
AAIVKMANKGN

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=44.1717791411043, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=42.638036809816, Blast_Score=264, Evalue=8e-71,
Organism=Homo sapiens, GI4557353, Length=333, Percent_Identity=38.7387387387387, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI34101272, Length=333, Percent_Identity=38.7387387387387, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1786622, Length=234, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538422, Length=327, Percent_Identity=45.565749235474, Blast_Score=290, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17506935, Length=330, Percent_Identity=39.3939393939394, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319698, Length=328, Percent_Identity=44.8170731707317, Blast_Score=289, Evalue=4e-79,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=41.7177914110429, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=41.7177914110429, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI160714828, Length=334, Percent_Identity=38.0239520958084, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI160714832, Length=334, Percent_Identity=38.0239520958084, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24650943, Length=85, Percent_Identity=41.1764705882353, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650945, Length=85, Percent_Identity=41.1764705882353, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645119, Length=236, Percent_Identity=27.5423728813559, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551847, Length=236, Percent_Identity=27.5423728813559, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550715, Length=236, Percent_Identity=27.5423728813559, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35837; Mature: 35706

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDTP
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCC
ISEAAISGAAIGAAITGLRPIVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFRV
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEECCEEEEE
ASGSGIGSAAQHSQSLEAWLTHIPGIKVVAPGNANDAKGLLKSAIRDNNIVLFMEPKALY
ECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCHHHC
GKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDPR
CCHHHCCCCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCC
TLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASED
EECCCCHHHHHHHHHHCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
VPVPYARVLEQAILPDVEKIKAAIVKMANKGN
CCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTSVGMIEEFGPKRVKDTP
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCC
ISEAAISGAAIGAAITGLRPIVDVTFMDFLTIMMDAIVNNGAKNNYMFGGGLITPVTFRV
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEECCEEEEE
ASGSGIGSAAQHSQSLEAWLTHIPGIKVVAPGNANDAKGLLKSAIRDNNIVLFMEPKALY
ECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCHHHC
GKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLERVLQAAEEVAADGINVEVVDPR
CCHHHCCCCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCC
TLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEIATMITESEAFDYLDHPIVRLASED
EECCCCHHHHHHHHHHCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
VPVPYARVLEQAILPDVEKIKAAIVKMANKGN
CCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]