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The map label for this gene is parC

Identifier: 15674931

GI number: 15674931

Start: 754392

End: 756851

Strand: Direct

Name: parC

Synonym: SPy_0910

Alternate gene names: 15674931

Gene position: 754392-756851 (Clockwise)

Preceding gene: 15674930

Following gene: 15674932

Centisome position: 40.72

GC content: 40.24

Gene sequence:

>2460_bases
ATGTCAAACATTCAAAACATGTCCCTTGAGGATATTATGGGAGAACGCTTCGGCCGTTATTCCAAGTATATTATTCAGGA
ACGGGCACTTCCTGATATTCGAGATGGATTGAAACCCGTTCAGCGTCGGATTCTTTATTCGATGAATAAGGATGGCAATA
CTTTTGAAAAAGGTTACCGTAAATCAGCCAAATCAGTTGGTAATATTATGGGGAATTTCCACCCACATGGGGATTCCTCT
ATTTATGATGCCATGGTACGGATGAGTCAAGATTGGAAGAACCGTGAAATCCTTGTTGAAATGCACGGAAATAATGGTTC
AATGGATGGTGATCCGCCTGCGGCTATGCGTTATACAGAAGCTCGCTTGTCTGAAATTGCGGGTTATCTTCTTCAAGACA
TTGAGAAAAATACGGTCTCTTTTGCTTGGAACTTTGATGACACAGAAAAAGAACCCACCGTTTTACCAGCAGCTTTTCCT
AACTTACTTGTCAATGGGTCTTCTGGTATTTCCGCAGGCTATGCGACAGATATTCCACCGCACAATTTGTCAGAAGTGAT
TGATGCTGTTGTGTATATGATTGATCATCCCAAAGCTAGTTTAGAGAAATTAATGGAGTTTTTACCAGGACCAGATTTCC
CGACAGGAGGCATTATCCAAGGAGCTGACGAAATCAAAAAAGCCTACGAAACAGGTAAGGGACGTGTCGTTGTTCGCTCT
AGGACAGAAATCGAGGAACTTAAAGGTGGTAAACAACAAATTATTGTCACTGAGATTCCTTATGAAGTTAACAAAGCAGT
CTTGGTCAAAAAGATTGACGATGTGCGTGTTAACAATAAAGTCCCAGGCATCGTAGAAGTACGCGATGAATCTGATCGCA
CAGGTCTTCGCATAGCTATTGAGTTGAAAAAAGAGGCTGATAGCCAAACCATTCTAAATTATTTGTTGAAATACACAGAC
CTTCAAGTTAATTATAATTTTAACATGGTTGCTATTGACCACTTCACACCACGTCAAGTAGGACTTCAAAAAATACTATC
AAGCTATATCAGTCACCGTAAAGATATTATTATTGAGCGGTCTAAATTCGATAAAGCCAAAGCTGAAAAACGCCTCCACA
TTGTTGAAGGATTGATTCGTGTCTTGTCCATCTTAGATGAGATTATTGCTTTGATTAGATCGTCTGACAATAAGGCTGAT
GCTAAAGAAAATCTGAAAGTCAGCTATGATTTCTCTGAGGAACAAGCAGAAGCGATTGTAACCTTGCAGCTTTATCGTTT
AACTAATACCGATATTGTTACTCTCCAAAATGAAGAAAATGATTTAAGAGACTTAATCACGACCCTTTCCGCTATTATCG
GTGACGAAGCAACCATGTATAACGTCATGAAACGTGAATTAAGAGAGGTGAAAAAGAAATTCGCCAATCCTCGTTTATCA
GAGTTACAAGCAGAAAGTCAAATCATTGAGATTGACACTGCCAGCTTGATTGCAGAGGAAGAAACTTTTGTTAGTGTGAC
ACGGGGCGGATACCTCAAAAGAACCAGCCCACGATCCTTCAATGCGTCTAGTTTGGAAGAAGTTGGCAAGAGAGATGATG
ACGAACTCATCTTCGTTAAACAGGCCAAAACAACAGAACACCTTTTGTTATTTACAACTTTAGGCAATGTCATTTACCGG
CCAATCCATGAATTGACCGATTTACGTTGGAAGGATATCGGTGAACATTTATCACAAACCATTTCAAACTTCGCGACAGA
AGAAGAGATTCTCTACGCTGATATTGTGACTTCCTTTGACCAGGGCTTGTATGTGGCTGTCACACAAAATGGTTTTATCA
AACGCTTTGATCGTAAAGAACTAAGTCCTTGGCGAACTTATAAATCTAAATCAACCAAATATGTGAAGCTAAAGGATGAC
AAAGACCGCGTGGTTACCTTGTCACCAGTTATTATGGAAGACCTCCTATTAGTGACTAAAAATGGTTATGCTTTGCGATT
CTCCAGTCAGGAAGTGCCTATTCAAGGGTTGAAATCTGCTGGTGTTAAAGGCATTAACTTGAAAAACGATGACAGCCTTG
CCTCAGCCTTTGCTGTGACAAGTAACTCTTTCTTTGTCTTAACTCAGAGGGGTTCTCTCAAACGGATGGCTGTCGATGAT
ATTCCTCAGACAAGTCGTGCCAATCGTGGACTATTGGTCCTACGAGAGTTAAAAACCAAACCTCATAGAGTTTTTCTGGC
CGGAGGCGTTCAATCAGATACTTCAGCTGAGCAGTTTGATTTGTTCACTGATATACCTGAAGAAGAAACTAATCAACAAA
TGCTTGAAGTCATTAGTAAGACTGGTCAAACCTACGAGATTGCTTTAGAAACGCTTTCGTTATCGGAAAGAATCAGCAAC
GGCTCCTTTATTTCAGACACTATTTCGGATCAAGAAGTACTGGTAGCTAGAACACGTTAA

Upstream 100 bases:

>100_bases
GGTGTTTTAGTCATACAAGTTTCTCACAGATAATTACAAGTGCTAAAGACGATTGTTTTTTAGGTAATTAATAAATAATG
AAAAAGAAAGCTATTTGAAT

Downstream 100 bases:

>100_bases
AAAGAGTGAAAACTCTTTTTAATTTTATGATAAATTTAGAATATTAATACAAAAGAATAGAATAAACTTGAAAATTATTG
AAAAAAAGTTACAATAGAAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSS
IYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFP
NLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS
RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTD
LQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKAD
AKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS
ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYR
PIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDD
KDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD
IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERISN
GSFISDTISDQEVLVARTR

Sequences:

>Translated_819_residues
MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSS
IYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFP
NLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS
RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTD
LQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKAD
AKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS
ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYR
PIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDD
KDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD
IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERISN
GSFISDTISDQEVLVARTR
>Mature_818_residues
SNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSSI
YDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPN
LLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRSR
TEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTDL
QVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADA
KENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLSE
LQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYRP
IHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDK
DRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDDI
PQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERISNG
SFISDTISDQEVLVARTR

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family

Homologues:

Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=25.1572327044025, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI19913406, Length=318, Percent_Identity=24.5283018867925, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=804, Percent_Identity=37.3134328358209, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1789396, Length=728, Percent_Identity=32.2802197802198, Blast_Score=350, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17535065, Length=181, Percent_Identity=29.2817679558011, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=179, Percent_Identity=29.0502793296089, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=398, Percent_Identity=25.1256281407035, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=187, Percent_Identity=26.7379679144385, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17136538, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PARC_STRP1 (Q9L7Q4)

Other databases:

- EMBL:   AF220946
- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269105.1
- RefSeq:   YP_282075.1
- ProteinModelPortal:   Q9L7Q4
- EnsemblBacteria:   EBSTRT00000000531
- EnsemblBacteria:   EBSTRT00000028997
- GeneID:   3572188
- GeneID:   901064
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0910
- KEGG:   spz:M5005_Spy_0712
- GeneTree:   EBGT00050000028052
- HOGENOM:   HBG635183
- OMA:   EVMGDRF
- ProtClustDB:   PRK05561
- BioCyc:   SPYO160490:SPY0910-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0712-MONOMER
- GO:   GO:0005694
- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741
- Gene3D:   G3DSA:3.30.1360.40
- Gene3D:   G3DSA:3.90.199.10
- SMART:   SM00434
- TIGRFAMs:   TIGR01061

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; SSF56719 Topo_IIA_cen

EC number: 5.99.1.-

Molecular weight: Translated: 92479; Mature: 92348

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: ACT_SITE 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYR
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
ARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDIPP
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCHHEEECCCCCCCCCCCCCCC
HNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC
RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAI
CHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCEEEEE
ELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIER
EECCCCCHHHHHHHHHHHHEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCHHEEEEC
SKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEAIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHEEE
TLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS
EEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH
ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVK
HHHCCCEEEEEEHHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHCCCCCCCEEEEE
QAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFD
ECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
QGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLVTK
CCEEEEEECCCHHHHCCHHCCCHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHEEC
NGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD
CCEEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEECCCEEEEECCCCCCHHHHHC
IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISK
CCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
TGQTYEIALETLSLSERISNGSFISDTISDQEVLVARTR
CCCEEEEHHHHHHHHHHCCCCCEEECCCCCCEEEEEECC
>Mature Secondary Structure 
SNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
ARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDIPP
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCHHEEECCCCCCCCCCCCCCC
HNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC
RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAI
CHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCEEEEE
ELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIER
EECCCCCHHHHHHHHHHHHEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCHHEEEEC
SKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEAIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHEEE
TLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS
EEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH
ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVK
HHHCCCEEEEEEHHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHCCCCCCCEEEEE
QAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFD
ECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
QGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLVTK
CCEEEEEECCCHHHHCCHHCCCHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHEEC
NGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD
CCEEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEECCCEEEEECCCCCCHHHHHC
IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISK
CCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
TGQTYEIALETLSLSERISNGSFISDTISDQEVLVARTR
CCCEEEEHHHHHHHHHHCCCCCEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296