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The map label for this gene is pyrC

Identifier: 15674928

GI number: 15674928

Start: 750250

End: 751518

Strand: Direct

Name: pyrC

Synonym: SPy_0907

Alternate gene names: 15674928

Gene position: 750250-751518 (Clockwise)

Preceding gene: 15674927

Following gene: 15674930

Centisome position: 40.5

GC content: 41.06

Gene sequence:

>1269_bases
ATGATACTCATCAAAAATGGACGCGTTATGGACCCGAAATCGCAGAGAGATCAAGTGGCAGATGTCTTGATTGATGGTAA
ACAGATTGTAAAGATAGCTTCAGCTATTGAATGCCAAGAAGCTCAAGTGATTGATGCTAGTGGTCTTATTGTTGCCCCGG
GTTTGGTCGATATTCATGTGCATTTTAGAGAACCCGGTCAAACGCACAAAGAAGATATTCACACGGGAGCCTTGGCAGCA
GCAGCAGGTGGTGTGACTACGGTTGTCATGATGGCTAATACCAATCCTGTCATTTCAGATGTCGAAACTTTACAGGAAGT
GCTAGCTAGCGCAGCTAAAGAAAAGATTCATATTTACACCAATGCCAGTGTCACCCAAGCCTTTAATGGAAAAGACGTGA
CTGATTTTAAAGCTTTGTTGGAAGCAGGAGCAGTAAGCTTTTCAGATGATGGTATTCCCTTAGAAAGTTCTAAAGTTTTA
AAAGAAGCCTTTGATTTGGCTAATGCCAACCAAACTTTCATTTCTTTGCATGAGGAAGATCCTCAGTTAAATGGGGTTCT
TGGTTTTAATGAAGGTATTGCTGAGGAGCATTTTCATTTTTGTGGGGCAACTGGTGTAGCAGAATATAGTATGATTGCAA
GAGATGTCATGATTGCTTATGACAGGCAAGCTCATGTTCATATCCAACATTTATCTAAAGCAGAATCGGTTCAAGTAGTG
GCTTTTGCTCAGCAGTTGGGTGCTAAGGTAACTGCTGAAGTGTCCCCACAACATTTTTCAACAACTGAAGATCTCTTATT
GATCGCAGGTACCAGCGCCAAGATGAATCCTCCCCTTCGTACACAAAGAGATCGCTTAGCTGTCATAGAAGGCTTGAAAT
CGGGTGTTATCACAGTCATTGCCACTGATCATGCTCCTCATCACAAGGATGAAAAAACTGTGGATGATATGACTAAAGCC
CCATCTGGTATGACAGGACTTGAAACTTCTTTGTCATTAGGTTTGACGCATTTGGTTGAACCAGGTCATCTTACACTTAT
GTCACTATTAGAAAAAATGACGCTTAATCCAGCTTTGCTTTATGGTTTTGATGCGGGTTATTTGGCAGAAAATGGTCCAG
CAGATTTGGTTATTTTTGCAGACAAGCAAGAACGTCTGATCACTGAGAATTTTGCTTCTAAAGCTAGTAATTCCCCATTT
ATTGGTAACAAACTCAAAGGTGTCGTGAAATACACTATTGCAGACGGAGAGGTTGTTTACCCTAATTAA

Upstream 100 bases:

>100_bases
GACATTTTGATACCTTTAATAAGTGAAATGAGTGCAGTAGATTTTTCCTATTAAAGAACGTAAGGTCTTATGGTTAAAAC
AGATAAATAAAGGAGAAAAC

Downstream 100 bases:

>100_bases
CAAATGAGTTAAAACAAAAAAGCTTGACTTTCAGAGAAAGTCAGGCTTTTAGTAAATTTATTTTTTAGGCACTTGTTTGC
TTAAATTTAGCCCCCAAGGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKTVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPF
IGNKLKGVVKYTIADGEVVYPN

Sequences:

>Translated_422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKTVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPF
IGNKLKGVVKYTIADGEVVYPN
>Mature_422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKTVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPF
IGNKLKGVVKYTIADGEVVYPN

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=391, Percent_Identity=31.9693094629156, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4503051, Length=453, Percent_Identity=22.5165562913907, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI62422571, Length=453, Percent_Identity=22.5165562913907, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=29.0617848970252, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87082175, Length=448, Percent_Identity=27.2321428571429, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=402, Percent_Identity=32.8358208955224, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI86575075, Length=452, Percent_Identity=24.5575221238938, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=398, Percent_Identity=26.6331658291457, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=30.7894736842105, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI18859883, Length=409, Percent_Identity=26.6503667481663, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_STRP1 (Q9A071)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269102.1
- RefSeq:   YP_282072.1
- ProteinModelPortal:   Q9A071
- SMR:   Q9A071
- EnsemblBacteria:   EBSTRT00000001604
- EnsemblBacteria:   EBSTRT00000028595
- GeneID:   3572221
- GeneID:   901061
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0907
- KEGG:   spz:M5005_Spy_0709
- GeneTree:   EBGT00050000027778
- HOGENOM:   HBG724623
- OMA:   PRVAEES
- ProtClustDB:   PRK09357
- BioCyc:   SPYO160490:SPY0907-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0709-MONOMER
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 45291; Mature: 45291

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHV
CEEECCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCEEECCEEEEEE
HFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYT
EECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEE
NASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEED
CCCEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
PQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
CCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCEEEHHHHCCCCCCHHH
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVI
HHHHHHCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEE
ATDHAPHHKDEKTVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALL
EECCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHCCCCEEE
YGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPFIGNKLKGVVKYTIADGEVVY
EECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCEEEC
PN
CC
>Mature Secondary Structure
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHV
CEEECCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCEEECCEEEEEE
HFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYT
EECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEE
NASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEED
CCCEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
PQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
CCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCEEEHHHHCCCCCCHHH
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVI
HHHHHHCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEE
ATDHAPHHKDEKTVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALL
EECCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHCCCCEEE
YGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPFIGNKLKGVVKYTIADGEVVY
EECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCEEEC
PN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296