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The map label for this gene is gor [H]

Identifier: 15674854

GI number: 15674854

Start: 669065

End: 670417

Strand: Direct

Name: gor [H]

Synonym: SPy_0813

Alternate gene names: 15674854

Gene position: 669065-670417 (Clockwise)

Preceding gene: 15674853

Following gene: 15674857

Centisome position: 36.12

GC content: 43.09

Gene sequence:

>1353_bases
ATGGTTATTCCTTATGATTATATTGTTATTGGTGGAGGGAGTGCAGGTATTGCTTCTGCGAACAGGGCAGCCATGCATGG
GGCCAAAGTATTGTTAGCTGAAGGTAAAGAGATTGGGGGAACCTGTGTTAACCTAGGCTGCGTTCCTAAAAAAGTCATGT
GGTATGGCGCTCAAGTAGCAGATATTTTAGGGACTTACGCTAAGGATTATGGATTTGACTTTAAAGAGAAAGCATTTGAT
TTTAAACAATTGAAAGCAAATCGTCAAGCTTATATTGATCGGATTCATGCTTCTTATGAGCGAGGCTTTGAGCAGAATGG
TGTTGACCGTATTTATGATTATGCTGTTTTCAAAGATGCTCATACGGTAGAAATTGCAGGGCAGCTTTATACCGCACCGC
ATATTTTGATTGCTACAGGAGGACATCCTGTTTTTCCAGATATTGAGGGGGCACAATACGGTATCAGCTCGGACGGCTTT
TTTGCCTTAGATGAGGTACCAAAACGTACGGCTGTGGTTGGGGCAGGCTATATTGCTGTGGAACTTGCTGGTGTTTTGCA
TGCTTTGGGATCGAAGACGGATTTGTTTATCCGTCACGATCGACCTTTAAGAAGTTTTGACAAAACCATTGTTGATGTCT
TAGTTGATGAAATGGCAGTTAATGGGCCGCGTTTACACACTCATGCAGAAGTGGCAAAGGTTGTCAAAAATACTGATGAG
TCCTTGACCCTTTACCTCAAAGATGGCCAAGAAGTTGAGGTTGACCAGCTCATTTGGGCTATCGGTCGCAAGCCTAATCT
AGAAGGTTTTAGTCTTGACAAAACTGGAGTGACGTTAAATGATAAAGGTTATATTGAGACAGATGCCTATGAAAACACGT
CTGTCAAAGGTATTTATGCCGTGGGAGATGTTAATGGGAAACTGGCTTTAACTCCAGTTGCTGTGGCAGCTGGACGTCGC
CTATCAGAGCGTCTTTTCAATGGCAAAACAGACGAGAAATTGGACTACCAAAACGTTGCTACTGTGATTTTTAGTCACCC
TGTTATTGGCTCTGTTGGCTTGTCAGAAGAAGCAGCAGTCAAACAGTATGGGCAAGAAGCAGTTAAAACATATCAATCAC
GTTTTACGTCTATGTTTACTGCTATCACTAACCATCGCCAACCTTGTCTGATGAAGTTGGTAACAGTCGGAGATACCGAA
AAAATAGTTGGTCTTCACGGAATCGGATACGGGGTTGACGAAATGATTCAGGGCTTTGCAGTAGCCATCAAAATGGGAGC
AACCAAGGCGGATTTTGATAACACCGTTGCTATTCACCCAACTGGCTCAGAAGAATTTGTCACCATGCGCTAA

Upstream 100 bases:

>100_bases
GTGACCAAAATAGCAGGCCAGTAGTGGCTTTAATGAAGGCAAGTTGTCTGCTAACTGGCTGTGCTAAAACATCAGTATTA
GAAAGTAAAAGGTGATAAAA

Downstream 100 bases:

>100_bases
AAAATGTAGCCTAAGGCAATAAAAAATGATGTTAACAGTTTTTGAGGAAAGTCTTCTAAACTGCTAGCATCGTTTTTTGT
TAGGTGATTAGGGGAATATG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVADILGTYAKDYGFDFKEKAFD
FKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDAHTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGF
FALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHAEVAKVVKNTDE
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRR
LSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTE
KIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Sequences:

>Translated_450_residues
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVADILGTYAKDYGFDFKEKAFD
FKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDAHTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGF
FALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHAEVAKVVKNTDE
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRR
LSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTE
KIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
>Mature_450_residues
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVADILGTYAKDYGFDFKEKAFD
FKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDAHTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGF
FALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHAEVAKVVKNTDE
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRR
LSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTE
KIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=52.4838012958963, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=38.3442265795207, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=33.8461538461538, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=33.8461538461538, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=33.8461538461538, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=33.8461538461538, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=33.8461538461538, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI291045266, Length=459, Percent_Identity=32.0261437908497, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI291045268, Length=459, Percent_Identity=28.5403050108932, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=29.004329004329, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=63.5555555555556, Blast_Score=563, Evalue=1e-162,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=26.3274336283186, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=26.133909287257, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=24.5575221238938, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=52.9933481152993, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=52.9933481152993, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=35.5932203389831, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=31.8840579710145, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=28.82096069869, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=48.7012987012987, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=26.9978401727862, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=464, Percent_Identity=25.2155172413793, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=39.4514767932489, Blast_Score=268, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=39.4514767932489, Blast_Score=268, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=39.4514767932489, Blast_Score=267, Evalue=9e-72,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=37.1848739495798, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=28.2377919320594, Blast_Score=154, Evalue=8e-38,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48916; Mature: 48916

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVA
CCCCEEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCEEEECCCCCHHHHHHCHHHH
DILGTYAKDYGFDFKEKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDA
HHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
HTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGFFALDEVPKRTAVVGAGYIAV
CEEEEECEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCHHHH
ELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHAEVAKVVKNTDE
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIETDAYENTSVKGIYA
EEEEEEECCCCCCHHHHHHHHCCCCCCCCEEECCCCEEECCCCCEEECCCCCCCCEEEEE
VGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAV
EECCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
KQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIVGLHGIGYGVDEMIQGFA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHEEEEECCCCCHHHHHHHHE
VAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEECCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVA
CCCCEEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCEEEECCCCCHHHHHHCHHHH
DILGTYAKDYGFDFKEKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDA
HHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
HTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGFFALDEVPKRTAVVGAGYIAV
CEEEEECEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCHHHH
ELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHAEVAKVVKNTDE
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIETDAYENTSVKGIYA
EEEEEEECCCCCCHHHHHHHHCCCCCCCCEEECCCCEEECCCCCEEECCCCCCCCEEEEE
VGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAV
EECCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
KQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIVGLHGIGYGVDEMIQGFA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHEEEEECCCCCHHHHHHHHE
VAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEECCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8525054 [H]