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The map label for this gene is ezrA

Identifier: 15674783

GI number: 15674783

Start: 584000

End: 585724

Strand: Direct

Name: ezrA

Synonym: SPy_0728

Alternate gene names: 15674783

Gene position: 584000-585724 (Clockwise)

Preceding gene: 15674782

Following gene: 15674785

Centisome position: 31.53

GC content: 36.93

Gene sequence:

>1725_bases
ATGTCAAGCGGAATTATCTTGCTGATTGTGGCTATAGTCCTACTAGTGATTATCGCCTATCTAGTGGGTGTCATCATACG
AAAGCGTAATGATTCCCTAATTACCAGTCTAGAAGAACGAAAACAGGCCTTGTTTGCTTTGCCTGTTAATGATGAAATTG
AAGAAGTAAAGTCACTTCATTTGATAGGACAGAGCCAAACCTCTTTTCGGGAATGGAATCAGAAATGGGTAGACTTAACT
GTGAATTCGTTTGCAGATATTGAAAATCATATTTTTGAAGCTGAAAATTTGAATGATACGTTTAATTTTATTCGCGCCAA
GCATGAGATTAATAGCGTTGAAAGTCAGCTTAATCTTGTTGAAGAAGATATCGCTTCTATTCGTGAAGCACTTAATATCT
TAAAAGAGCAAGAAGAAAAAAATAGTGCTCGTGTCACCCATGCTCTTGATTTATATGAAAAGCTCCAAGCTTCTATTTCT
GAGAATGAAGATAATTTTGGTTCAACTATGCCTGAAATTGACAAACAGATGAAAAACATTGAAACTGAATTTTCACAGTT
TGTCGCACTCAACTCATCAGGTGATCCTGTAGAAGCTTCTGAAGTTCTGGATAGAGCAGAAGAGCATACTATTGCTCTAG
GGCAGATTACAGAGCAGATTCCAGCTATTGTGGCCAAGTTGGAAGATGATTTTCCAGATCAGTTAGATGATTTGGAAACA
GGATATCGCCGTTTACTTGAAGAAAACTATCATTTTCCAGAAAAAAACATTGAGGCACGTTTTCAGGAGATTCGTGAGTC
TATTCGTGCCAATTCATCAGAGTTAGTTACACTTGACTTGGATCGTGCTAGAGAAGAAAACACGCATATTCAAGAACGCA
TTGATTCTCTTTATGAAGTCTTTGAGCGCGAAATTGCCGCTTATAAGGTAGCTGCTAAAAATAGTAAGATGCTACCTCGT
TACCTAGAACATGTGAAACGTAATAATGAACAACTCAAAGATGAAATTGCACGTTTATCACGTAAATATATTCTAAGTGA
AACGGAAAGTCTGACTGTTAAGGCATTTGAGAAGGATATTAAAGAGATAGAAGACAGTACACTTGCTGTTGCAGAACAAT
TTGGTTTACAAGAAAAACCATTTTCAGAACTGCAAGTGACTTTTGAACGCAGTATAAAGACGCTTACTAATGTCGAGTCA
GGTCAAATGGATGTTTTTGCAGCAGTTAAAGATATTGAAAAAATTGAATCACAGGCACGCCATAACCTTGATGTTTATGT
TACTCAGCTTCATATGATTAAACGTTATATGGAAAAACGTCACTTGCCTGGAATTCCACAAGACTTTCTTAGTGCTTTCT
TTACAACGAGTTCACAATTGGAAGCTTTGATGGATGAGCTTAGTAGAGGACGGATCAATATTGAGGCAGTGTCACGTTTG
TCGGAAGTTGCGACGGTTGCTATTGCTAATCTAGAAGATTTAACCTATCAAGTGGTTCAAAATGCTACCTTGACTGAACA
ATTACTACAATATTCTAATCGCTATCGTTCTTTTGAAGCAGGAGTTCAAAGTAGTTTTGAACATGCTTTGAGACTTTTCG
AAGTAGAAAATGATTATCAGGCTTCTTTTGATGAAATTTCTTATGCTCTTGAAACAGTTGAACCTGGGGTAACAGATCGG
TTTGTTAACTCTTATGAAAAAACACGAGAGCACATTCGTTTTTGA

Upstream 100 bases:

>100_bases
TTTAAATAAAATTTTAATAAAAGGCGATTGAGGAATTTCAGTTTTTAGTTATTACTGGAACAATGTTGATAAATCGTGTC
TAAATAATAAGGAGATTCAG

Downstream 100 bases:

>100_bases
TACTTGAAAGTCGTGATATTCTCACGACTTTTTATTAGCTTTTTGGACCAATACGTGTTTTTGACTAGAATCTTCTTTTT
AATGATCAAACGAAGAAGTA

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLT
VNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASIS
ENEDNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLET
GYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEVFEREIAAYKVAAKNSKMLPR
YLEHVKRNNEQLKDEIARLSRKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVES
GQMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRL
SEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDR
FVNSYEKTREHIRF

Sequences:

>Translated_574_residues
MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLT
VNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASIS
ENEDNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLET
GYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEVFEREIAAYKVAAKNSKMLPR
YLEHVKRNNEQLKDEIARLSRKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVES
GQMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRL
SEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDR
FVNSYEKTREHIRF
>Mature_573_residues
SSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLTV
NSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASISE
NEDNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLETG
YRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEVFEREIAAYKVAAKNSKMLPRY
LEHVKRNNEQLKDEIARLSRKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVESG
QMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRLS
EVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDRF
VNSYEKTREHIRF

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EZRA_STRP1 (Q9A0K9)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268957.1
- RefSeq:   YP_281917.1
- ProteinModelPortal:   Q9A0K9
- EnsemblBacteria:   EBSTRT00000001138
- EnsemblBacteria:   EBSTRT00000027652
- GeneID:   3572339
- GeneID:   900913
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0728
- KEGG:   spz:M5005_Spy_0554
- GeneTree:   EBGT00050000028049
- HOGENOM:   HBG697174
- OMA:   MDIQELH
- ProtClustDB:   PRK04778
- BioCyc:   SPYO160490:SPY0728-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0554-MONOMER
- HAMAP:   MF_00728
- InterPro:   IPR010379

Pfam domain/function: PF06160 EzrA

EC number: NA

Molecular weight: Translated: 66121; Mature: 65990

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb1eec94)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLH
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHH
LIGQSQTSFREWNQKWVDLTVNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASISENEDNFGSTMPEIDKQMKNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLET
HHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHH
FEREIAAYKVAAKNSKMLPRYLEHVKRNNEQLKDEIARLSRKYILSETESLTVKAFEKDI
HHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVESGQMDVFAAVKDIEKIESQAR
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
HNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRL
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
SEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ASFDEISYALETVEPGVTDRFVNSYEKTREHIRF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLH
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHH
LIGQSQTSFREWNQKWVDLTVNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASISENEDNFGSTMPEIDKQMKNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLET
HHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHH
FEREIAAYKVAAKNSKMLPRYLEHVKRNNEQLKDEIARLSRKYILSETESLTVKAFEKDI
HHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVESGQMDVFAAVKDIEKIESQAR
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
HNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRL
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
SEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ASFDEISYALETVEPGVTDRFVNSYEKTREHIRF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296