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The map label for this gene is 15674638

Identifier: 15674638

GI number: 15674638

Start: 438736

End: 439935

Strand: Direct

Name: 15674638

Synonym: SPy_0538

Alternate gene names: NA

Gene position: 438736-439935 (Clockwise)

Preceding gene: 15674637

Following gene: 15674639

Centisome position: 23.68

GC content: 29.75

Gene sequence:

>1200_bases
ATGGATTTAAAAATTACAAACGGCTTTTATGACCCAAGTCATTTATCATACGAAGTAGTAGAACGCAAAGGCTTAGGTCA
CCCTGATACCTTAGCAGATGGAATTGCTGAGCAAATTGAAATTGATTACTCACTTTATTGTTTGGACAAGTTTGGTGTTA
TTCCACATCATAATTTTGATAAGATTATTATCCGAGGGGGACATTCAGTTCAGGATTTTGGTGGAAGTGACTTTATTGAA
CCAATTAAAATTATTTTTCTAGGTAGGGCGAGCAAAAAATGTTTTAATAGTTCAATTCCACTTTTTAAAATTCAGAAAAA
GGCTGCAACTAAATATTTAAATAGAATTTTACCTAATTTAGATGTTGAAAATTATGTAGAATTTGAGACATTGACCTCAG
ATTTTACTACAAAAACTAATTGGTTCTCGCCTGAAGCAATAGAAGATTTACCGGAGTATCTAGATGTACCAAAGGCAAAT
GATACAGCTACAATGATAAGTTATTGGCCATTAACAATTTCTGAAGAATTAGCATTAATGATTGAAGGGTATTTTTATAA
ATTAGATAAGAATGAATTACCAACGCCAAGATTTACTAAAATGGGTGGTGATATTAAAGTAATGGTCGTAAGGAACGATT
TAGAATATTCTATTAGAATAAATTTTCCTTTAATAAGTAAATTTTTTAACAATGATATTGAAAGTCAGTTGTATGTTGAT
AAACACGTAGAAAAAATTAAGAAATATATTGAACAAAAGTATAAAAACATAAGCTTTTCTATTGATTACCATTATTATTT
AACTACTACAGGTTCTTGTATTGATTTTGGAGAAGAAGGTGCAGTTGGTCGAGGTAATAAAACTCATGGTATCATATCAA
GTTTTAGGCCAAATACTATGGAAGCACCAGCTGGAAAAAATTGTACTTATTTTGTAGGAAAGGTTTGGGGATTTTTGTCT
GATACTATTGCCAAAGAAATTTATGAAGCATTCAATACTCCCTGTCAAATCATTATGCAATTAAATATTGGATCAAAATT
GTATAGACCAACCCATTTATTTATTCAGACAGAAGAAAGTGTTGATCAAGAAAGAGTATTAGAAATTGTTAACAGGCATT
TAAATAATGGTAAACAAAATACTAATTTAATCTTGTCAACTCAACATTTTATTCCTAAAACCAATGTCTATGATGGATAA

Upstream 100 bases:

>100_bases
TATTCCTGAAGATTGCTATATCAATAATGCAATTGAGATAACAAAATTATTAATTAACTTATATTCAGAATGTGAAAAAA
TTTATTTATGAGGTGTAACT

Downstream 100 bases:

>100_bases
AACTGTTTTATATTTTGGGTTGGTTGAAATTTCTTTTGATGTGCCTGACTTTATATTTCAAAAAATAAAAGAGCAGAATA
ATAAAATTAGATATTATAGC

Product: S-adenosylmethionine synthetase

Products: phosphate; diphosphate; S-adenosyl-L-methionine

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFDKIIIRGGHSVQDFGGSDFIE
PIKIIFLGRASKKCFNSSIPLFKIQKKAATKYLNRILPNLDVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKAN
DTATMISYWPLTISEELALMIEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTMEAPAGKNCTYFVGKVWGFLS
DTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEESVDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG

Sequences:

>Translated_399_residues
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFDKIIIRGGHSVQDFGGSDFIE
PIKIIFLGRASKKCFNSSIPLFKIQKKAATKYLNRILPNLDVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKAN
DTATMISYWPLTISEELALMIEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTMEAPAGKNCTYFVGKVWGFLS
DTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEESVDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG
>Mature_399_residues
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFDKIIIRGGHSVQDFGGSDFIE
PIKIIFLGRASKKCFNSSIPLFKIQKKAATKYLNRILPNLDVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKAN
DTATMISYWPLTISEELALMIEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTMEAPAGKNCTYFVGKVWGFLS
DTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEESVDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG

Specific function: Unknown

COG id: COG1812

COG function: function code E; Archaeal S-adenosylmethionine synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AdoMet synthetase 2 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y382_STRP3 (P66769)

Other databases:

- EMBL:   AE014074
- EMBL:   BA000034
- RefSeq:   NP_664186.1
- RefSeq:   NP_802733.1
- ProteinModelPortal:   P66769
- EnsemblBacteria:   EBSTRT00000033465
- EnsemblBacteria:   EBSTRT00000036610
- GeneID:   1008696
- GeneID:   1066550
- GenomeReviews:   AE014074_GR
- GenomeReviews:   BA000034_GR
- KEGG:   spg:SpyM3_0382
- KEGG:   sps:SPs1471
- GeneTree:   EBGT00050000030106
- HOGENOM:   HBG702657
- OMA:   RPMSMEA
- ProtClustDB:   PRK04439
- BioCyc:   SPYO193567:SPS1471-MONOMER
- BioCyc:   SPYO198466:SPYM3_0382-MONOMER
- InterPro:   IPR002795
- ProDom:   PD011777

Pfam domain/function: PF01941 AdoMet_Synthase

EC number: 2.5.1.6

Molecular weight: Translated: 45772; Mature: 45772

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFD
CCEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHEEECEEEEEEECCCCCCCCCCC
KIIIRGGHSVQDFGGSDFIEPIKIIFLGRASKKCFNSSIPLFKIQKKAATKYLNRILPNL
EEEEECCCCCCCCCCCCHHCEEEEEEECCCCHHHHCCCCCCEEEHHHHHHHHHHHHCCCC
DVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKANDTATMISYWPLTISEELALM
CHHHEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHEE
IEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
EEEEEEEECCCCCCCCHHHHCCCCEEEEEEECCCEEEEEECCHHHHHHHCCCCHHHHHHH
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTM
HHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCEEECCCCCCCCCCCCCCCHHHHCCCCCC
EAPAGKNCTYFVGKVWGFLSDTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEES
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEHHC
VDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG
CCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFD
CCEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHEEECEEEEEEECCCCCCCCCCC
KIIIRGGHSVQDFGGSDFIEPIKIIFLGRASKKCFNSSIPLFKIQKKAATKYLNRILPNL
EEEEECCCCCCCCCCCCHHCEEEEEEECCCCHHHHCCCCCCEEEHHHHHHHHHHHHCCCC
DVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKANDTATMISYWPLTISEELALM
CHHHEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHEE
IEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
EEEEEEEECCCCCCCCHHHHCCCCEEEEEEECCCEEEEEECCHHHHHHHCCCCHHHHHHH
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTM
HHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCEEECCCCCCCCCCCCCCCHHHHCCCCCC
EAPAGKNCTYFVGKVWGFLSDTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEES
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEHHC
VDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG
CCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-methionine; H2O

Specific reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12122206; 12799345