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The map label for this gene is aroE [H]

Identifier: 15674634

GI number: 15674634

Start: 435252

End: 436178

Strand: Direct

Name: aroE [H]

Synonym: SPy_0534

Alternate gene names: 15674634

Gene position: 435252-436178 (Clockwise)

Preceding gene: 15674632

Following gene: 15674635

Centisome position: 23.5

GC content: 27.83

Gene sequence:

>927_bases
ATGCTTGTACTTTATGTTAGTAGTAAACTAATTAAACGTAGGAGGATGAAATTTATGTATTCTGCATTGCTTGGTAATCC
AGTTGAACATTCTATATCAGATGAATTATTTGAATATCTAAATCACAACATAGGAGTTCTGGATGAATATAAACATAAAA
AAATTTTGGTAGACTCAGTGTGTTTAGAAGATAAAATCAAACATCTGATAAATGATCCAAAATGTATTGGATTAAATATA
ACTTTACCTTATAAAAGAGAGGTAATGAGGTATATTGACAATTTAGACAGAGTAGCAGAGATAACTGGATCTGTTAACAA
TATTTATAAATCTGGAAATATAATTACAGGAACTAATACTGATTGGAAAGGTATTTATAATACATTAGTTTTCTTTAATA
TTAGCCATATAACAAAATGTTGTGTTTTAGGTACTGGCGGTACTGCTAGAGCTGCTATTTTCGCTTTACAAAAACTACAA
ATCTCACCAACAGTTGTATACAGGGAGCCAATTAGTGAGAATACAAGAAGTTTGATAAAGAGTTTCCCTGATTTAAAGTA
TATTACATATAAGGAATTGGCTGATCAACAAATTTTAAATGATATGGAAATCATAATAAATACTACACCAGTTGGTATGA
TAAATTATGAAGAAAGTTTACCTATAAATTTTGATCATTTGGACAATGTTAATTATAAAGATAAATACTTTATGGATGTA
GTTTTCAATCCTTTACATACGAAACTTCATGAATATTTTGGTAAAAAAGGAGCAAAAATAATTGATGGTTTATGGGTTTT
GATTTTTCAGGGAATTGAAGCATTTTCATTGTGGAGTGATAAAATTAATGATGGTAAATATTTTTTTTCAAAAGATGATG
TTGTCCTAATTCATACATTTCTAGAAGGGAAGATAAAAGGAAAATGA

Upstream 100 bases:

>100_bases
CAATGGATATTATCATTATTGTTGGTGGGGAAGTTACTTAGGTGTACACTTAAGTCTTTAGAGTATCTAAAGACTTATAG
GTAATGGGTAGCTCTGTGTA

Downstream 100 bases:

>100_bases
CTTTTCACATTACAGTAAATCTTGATGAAATATCAGACAAACTAGATGATTCATTGAAATTTTTAAATAGATTATCAATT
AAAAGTTGTGAATTACGAAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNI
TLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFALQKLQ
ISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQILNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK

Sequences:

>Translated_308_residues
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNI
TLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFALQKLQ
ISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQILNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK
>Mature_308_residues
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNI
TLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFALQKLQ
ISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQILNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=285, Percent_Identity=27.719298245614, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1789675, Length=274, Percent_Identity=24.0875912408759, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320332, Length=168, Percent_Identity=33.9285714285714, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 35465; Mature: 35465

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSV
CEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHH
CLEDKIKHLINDPKCIGLNITLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNT
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCC
DWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFALQKLQISPTVVYREPISENTRSLIK
CHHHHHHHHHHEEHHHHHHHHEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
SFPDLKYITYKELADQQILNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
HCCCCEEEHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCHHCCCCCCCCHHHHHHH
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEECCCCEEEEEEE
LEGKIKGK
ECCEECCC
>Mature Secondary Structure
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSV
CEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHH
CLEDKIKHLINDPKCIGLNITLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNT
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCC
DWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFALQKLQISPTVVYREPISENTRSLIK
CHHHHHHHHHHEEHHHHHHHHEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
SFPDLKYITYKELADQQILNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
HCCCCEEEHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCHHCCCCCCCCHHHHHHH
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEECCCCEEEEEEE
LEGKIKGK
ECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]