Click here to switch to the map view.

The map label for this gene is vicK [H]

Identifier: 15674629

GI number: 15674629

Start: 427087

End: 428439

Strand: Direct

Name: vicK [H]

Synonym: SPy_0529

Alternate gene names: 15674629

Gene position: 427087-428439 (Clockwise)

Preceding gene: 15674628

Following gene: 15674630

Centisome position: 23.06

GC content: 37.77

Gene sequence:

>1353_bases
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAGGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Upstream 100 bases:

>100_bases
GATGTGACTGTTCGTCGCCTCCGTGAAAAAATTGAAGACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGT
TGGGTACTACATGAAATCTT

Downstream 100 bases:

>100_bases
TTAATGAATGAGAGTGGTTTTAAATACAGTATTTTAGCATCTGGGTCCACAGGAAATTGTTTTTATTTAGAAACACCTAA
AAAACGCTTATTGATTGATG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Sequences:

>Translated_450_residues
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD
>Mature_449_residues
TRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSDV
FRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPVV
TVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALKE
DIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITSV
WIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTGL
GLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=344, Percent_Identity=31.1046511627907, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786783, Length=224, Percent_Identity=31.6964285714286, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI145693157, Length=372, Percent_Identity=29.8387096774194, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=29.957805907173, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788549, Length=400, Percent_Identity=26.75, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994928, Length=252, Percent_Identity=27.7777777777778, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=32.0833333333333, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=26.6375545851528, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790346, Length=228, Percent_Identity=32.4561403508772, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=29.957805907173, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=29.4820717131474, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=25.8474576271186, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=206, Percent_Identity=28.1553398058252, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081816, Length=247, Percent_Identity=28.3400809716599, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=209, Percent_Identity=29.6650717703349, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787374, Length=245, Percent_Identity=29.3877551020408, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790300, Length=249, Percent_Identity=28.1124497991968, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=25.2212389380531, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51393; Mature: 51261

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDII
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHC
DEKADIELMELSDQLNDLSDVFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMIN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEE
ETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPVVTVNSRNDMGEFVSLRLRFA
HHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHH
LNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
HCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHH
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVK
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQHTGTGKVYEIVRDYPITSVWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDT
CCCCCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHCCEEECCCCCEEEEEEEECCE
QLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHHGFIWAK
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEE
SDYGKGSTFTIVLPYEKDAAIYEEWEEDVD
CCCCCCCEEEEEEECCCCCHHHHHHHHCCC
>Mature Secondary Structure 
TRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDII
CCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHC
DEKADIELMELSDQLNDLSDVFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMIN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEE
ETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPVVTVNSRNDMGEFVSLRLRFA
HHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHH
LNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
HCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHH
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVK
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQHTGTGKVYEIVRDYPITSVWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDT
CCCCCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHCCEEECCCCCEEEEEEEECCE
QLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHHGFIWAK
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEE
SDYGKGSTFTIVLPYEKDAAIYEEWEEDVD
CCCCCCCEEEEEEECCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]