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The map label for this gene is pcp

Identifier: 15674611

GI number: 15674611

Start: 407515

End: 408162

Strand: Reverse

Name: pcp

Synonym: SPy_0506

Alternate gene names: 15674611

Gene position: 408162-407515 (Counterclockwise)

Preceding gene: 15674612

Following gene: 15674601

Centisome position: 22.03

GC content: 42.9

Gene sequence:

>648_bases
ATGAAAATTCTTGTAACAGGCTTTGATCCCTTTGGCGGCGAAGCTATTAATCCTGCCCTTGAAGCTATCAAGAAATTGCC
AGCAACCATTCATGGAGCAGAAATCAAATGTATTGAAGTTCCAACGGTTTTTCAAAAATCTGCCGATGTGCTCCAGCAGC
ATATCGAAAGCTTTCAACCTGATGCAGTCCTTTGTATTGGGCAAGCTGGTGGCCGGACTGGACTAACGCCAGAACGCGTT
GCCATTAATCAAGACGATGCTCGCATTCCTGATAACGAAGGGAATCAGCCTATTGATACACCTATTCGTGCAGATGGTAA
AGCAGCTTATTTTTCAACCTTGCCAATCAAAGCGATGGTTGCTGCCATTCATCAGGCTGGACTTCCTGCTTCTGTTTCTA
ATACAGCTGGTACCTTTGTTTGCAATCATTTGATGTATCAAGCCCTTTACTTAGTGGATAAATATTGTCCAAATGCCAAA
GCTGGGTTTATGCATATTCCCTTTATGATGGAACAGGTTGTTGATAAACCTAATACAGCTGCCATGAACCTCGATGATAT
TACAAGAGGAATTGAGGCTGCTATTTTTGCCATTGTCGATTTCAAAGATCGTTCCGATTTAAAACGTGTAGGGGGCGCTA
CTCACTGA

Upstream 100 bases:

>100_bases
GTTTTAATTATTAGTCACATTGCCTTAATGTATTTACTTGCTTATTATTAACTTTTTTGCTAAGTTAGTAGCGTCAGTTA
TTCATTGAAAGGACATTATT

Downstream 100 bases:

>100_bases
CTGTGACGCTACTAAACCTATTTTAAAAAAACAGAGATATGAACTAACTCTGTTTTTTTGTGCTAAAAATGAAAGACCTA
GGGAAACTTTTCATCGGTCT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADVLQQHIESFQPDAVLCIGQAGGRTGLTPERV
AINQDDARIPDNEGNQPIDTPIRADGKAAYFSTLPIKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAK
AGFMHIPFMMEQVVDKPNTAAMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH

Sequences:

>Translated_215_residues
MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADVLQQHIESFQPDAVLCIGQAGGRTGLTPERV
AINQDDARIPDNEGNQPIDTPIRADGKAAYFSTLPIKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAK
AGFMHIPFMMEQVVDKPNTAAMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH
>Mature_215_residues
MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADVLQQHIESFQPDAVLCIGQAGGRTGLTPERV
AINQDDARIPDNEGNQPIDTPIRADGKAAYFSTLPIKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAK
AGFMHIPFMMEQVVDKPNTAAMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_STRP1 (P68896)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268785.1
- RefSeq:   YP_281780.1
- ProteinModelPortal:   P68896
- SMR:   P68896
- EnsemblBacteria:   EBSTRT00000000899
- EnsemblBacteria:   EBSTRT00000028971
- GeneID:   3572511
- GeneID:   900735
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0506
- KEGG:   spz:M5005_Spy_0417
- GeneTree:   EBGT00050000029708
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   SPYO160490:SPY0506-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0417-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23132; Mature: 23132

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 78-78 ACT_SITE 141-141 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADVLQQHIESFQP
CEEEEECCCCCCCCCCCHHHHHHHHCCCEECCCEEEEEECCHHHHHHHHHHHHHHHHCCC
DAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPIRADGKAAYFSTLPIKAMV
CEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHCCHHHHH
AAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAKAGFMHIPFMMEQVVDKPNTA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCCCC
AMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH
EECHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCC
>Mature Secondary Structure
MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADVLQQHIESFQP
CEEEEECCCCCCCCCCCHHHHHHHHCCCEECCCEEEEEECCHHHHHHHHHHHHHHHHCCC
DAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPIRADGKAAYFSTLPIKAMV
CEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHCCHHHHH
AAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAKAGFMHIPFMMEQVVDKPNTA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCCCC
AMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH
EECHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296