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The map label for this gene is era [H]

Identifier: 15674592

GI number: 15674592

Start: 389320

End: 390216

Strand: Direct

Name: era [H]

Synonym: SPy_0476

Alternate gene names: 15674592

Gene position: 389320-390216 (Clockwise)

Preceding gene: 15674591

Following gene: 15674593

Centisome position: 21.02

GC content: 40.25

Gene sequence:

>897_bases
ATGTTTAAATCAGGCTTTGTAGCCATTCTTGGTCGTCCAAATGTTGGCAAATCCACCTTTTTAAATCACGTCATGGGGCA
AAAAATTGCCATCATGAGTGACAAGGCTCAGACCACCCGTAATAAAATTATGGGCATTTACACCACAGAAACAGAACAAA
TTGTCTTTATTGATACGCCAGGTATTCATAAACCAAAGACCGCCCTTGGTGATTTTATGGTTGAATCTGCTTATAGTACT
TTACGTGAAGTTGAGACGGTTCTTTTCATGGTTCCTGCCGATGAAAAGCGTGGTAAGGGTGACGACATGATTATCGAGCG
GCTAAAAGCAGCTAAGATTCCCGTTATTTTAGTCATCAACAAAATTGATAAGGTTCATCCAGACCAACTTTTGGAACAGA
TTGATGACTTCCATAGCCAAATGGATTTTAAAGAAGTGGTCCCAATTTCTGCCCTAGAAGGTAATAATGTGCCAACTTTG
ATCAAGTTATTAACTGATAATCTTGAAGAAGGTTTCCAATATTTTCCAGAAGATCAGATTACTGATCATCCAGAACGTTT
CCTTGTGTCAGAAATGGTTCGTGAGAAGGTACTGCATTTGACGCAACAAGAGGTTCCACATTCCGTAGCTGTTGTTGTCG
AATCCATGAAGCGAGATGAAGAGACTGATAAAGTGCATATCCGTGCAACCATTATGGTGGAGCGCGATAGCCAAAAAGGC
ATCATCATTGGAAAACAAGGAGCCATGCTCAAAAAAATCGGAAAAATGGCGCGCCGTGATATTGAACTCATGTTAGGCGA
CAAGGTCTACTTAGAAACGTGGGTCAAAGTCAAGAAAAACTGGCGGGATAAAAAGCTTGATTTAGCTGATTTTGGCTATA
ATGAGAAAGAATACTAA

Upstream 100 bases:

>100_bases
CCTATGTGATGATGGCATAGGAGAATAAGGAAAGGACAAGACGGTTAAGCTTAGTGACAAGCTTGATCTGAAGCCCTACC
GTTAAAGCCCGTAATTATCT

Downstream 100 bases:

>100_bases
CATAGTAAAGCGAGATCATATGCCACAAGACTACATTTCTTATATCCGCTCCAAAGTTGGGCATGATAAGATTATTCTTA
ACTTTGCTGGTGGGATTTTG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTPGIHKPKTALGDFMVESAYST
LREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVINKIDKVHPDQLLEQIDDFHSQMDFKEVVPISALEGNNVPTL
IKLLTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKG
IIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY

Sequences:

>Translated_298_residues
MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTPGIHKPKTALGDFMVESAYST
LREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVINKIDKVHPDQLLEQIDDFHSQMDFKEVVPISALEGNNVPTL
IKLLTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKG
IIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY
>Mature_298_residues
MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTPGIHKPKTALGDFMVESAYST
LREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVINKIDKVHPDQLLEQIDDFHSQMDFKEVVPISALEGNNVPTL
IKLLTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKG
IIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=305, Percent_Identity=24.9180327868852, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788919, Length=292, Percent_Identity=43.8356164383562, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87082120, Length=156, Percent_Identity=34.6153846153846, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323665, Length=199, Percent_Identity=26.1306532663317, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24646434, Length=308, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34088; Mature: 34088

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTP
CCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHEEEEEECCCCEEEEEECC
GIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVIN
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEC
KIDKVHPDQLLEQIDDFHSQMDFKEVVPISALEGNNVPTLIKLLTDNLEEGFQYFPEDQI
CCCCCCHHHHHHHHHHHHHHCCHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCC
TDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCC
IIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY
EEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTP
CCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHEEEEEECCCCEEEEEECC
GIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVIN
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEC
KIDKVHPDQLLEQIDDFHSQMDFKEVVPISALEGNNVPTLIKLLTDNLEEGFQYFPEDQI
CCCCCCHHHHHHHHHHHHHHCCHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCC
TDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCC
IIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY
EEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA