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The map label for this gene is csd [H]

Identifier: 15674462

GI number: 15674462

Start: 250739

End: 251965

Strand: Direct

Name: csd [H]

Synonym: SPy_0288

Alternate gene names: 15674462

Gene position: 250739-251965 (Clockwise)

Preceding gene: 15674461

Following gene: 15674463

Centisome position: 13.54

GC content: 43.03

Gene sequence:

>1227_bases
TTGCTAGACGCAAAAGACATCAAACAAGACTTTCAAATCTTAAATCAACAAGTCAATGATGAACCCCTTGTTTATTTGGA
TAATGCCGCCACCACACAAAAACCGGCGCTTGTTCTTGAGGCTTTGCAATCCTATTATCAAGAAGATAATGCTAATGTCC
ACCGAGGAGTTCATACCTTGGCTGAACGTGCAACGCTCAAATATGAGGCCAGTCGCCAGCAGGTTGCTGACTTTATTCAT
GCTAAATCAAGTAAGGAAGTGCTCTTTACCAGAGGAACAACAACCAGTTTGAATTGGGTTGCTCGGTTTGCAGAGCAGGT
CTTGACGCCAGAAGATGAGGTGTTGATTTCGATTATGGAGCATCATGCCAATATCATTCCTTGGCAACAAGCCTGTCAAA
AAACAGGAGCAAGGTTAGTCTATGTTTATTTAAAAGATGGCCAACTTGACATGGACGATTTGGCAAACAAATTGACGACA
AAAACACGTTTTGTTAGCCTAGTACATGTCTCCAATGTTCTTGGTTGCATCAATCCCATTAAAGAAATTGCCAAGCTGGC
ACATGCTAAAGGAGCCTACCTTGTTGTTGACGGTGCCCAGTCGGTTCCACATTTGGCTATTGATGTTCAAGACTTGGATT
GTGATTTCTTTGCTTTTTCAGCTCATAAGATGTTGGGGCCAACAGGTTTGGGTGTTCTTTACGGCAAAGAAGAGCTTTTG
AATCAAGTGGAGCCTCTTGAATTTGGCGGAGAAATGATTGATTTTGTTTACGAACAAGAGGCCACTTGGAAAGAATTGCC
CTGGAAGTTTGAAGCAGGAACACCTCACATAGCTGGTGCTATTGGGCTAAGCGCAGCCATTTCTTACCTTCAGAGACTAG
GCATGGCTGATATACATGCGCATGAAGCAGAACTAATAGCCTATGTCTTGCCGAAATTAGAAGCTATTGAGGGGCTTACC
ATATATGGACCAAGCCAGCCTAGTGCAAGATCTGGTCTGATTTCTTTTAATCTGGATGATTTGCATCCTCATGACTTGGC
AACAGCCTTGGACTATGAAGGTGTTGCAGTAAGAGCAGGGCACCACTGCGCCCAACCTCTTCTTAGTTATTTAGGTGTAC
CAGCAACTGTTAGAGCAAGTTTTTATATCTATAACACCAAGGCAGATTGTGACCGTCTAGTCGAAGCAATTCTAAAAGCA
AAGGAGTTTTTCAATGGCACTCTCTAA

Upstream 100 bases:

>100_bases
TGAAATTCCTATTCCATCAGTCCGCCAAGAGATTATTAAGGTTTTAGATGAGAAATTGCTTAATCGTTAAGACCTACTGC
CAAAAAGAAAGAGGTTAGTA

Downstream 100 bases:

>100_bases
ACTGAACCATCTATACATGGCTGTGGTAGCGGACCATTCGAAACGTCCACATCATCATGGGCAACTAGATGGCGTAGAGG
CTGTTCAACTGAATAATCCG

Product: putative aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MLDAKDIKQDFQILNQQVNDEPLVYLDNAATTQKPALVLEALQSYYQEDNANVHRGVHTLAERATLKYEASRQQVADFIH
AKSSKEVLFTRGTTTSLNWVARFAEQVLTPEDEVLISIMEHHANIIPWQQACQKTGARLVYVYLKDGQLDMDDLANKLTT
KTRFVSLVHVSNVLGCINPIKEIAKLAHAKGAYLVVDGAQSVPHLAIDVQDLDCDFFAFSAHKMLGPTGLGVLYGKEELL
NQVEPLEFGGEMIDFVYEQEATWKELPWKFEAGTPHIAGAIGLSAAISYLQRLGMADIHAHEAELIAYVLPKLEAIEGLT
IYGPSQPSARSGLISFNLDDLHPHDLATALDYEGVAVRAGHHCAQPLLSYLGVPATVRASFYIYNTKADCDRLVEAILKA
KEFFNGTL

Sequences:

>Translated_408_residues
MLDAKDIKQDFQILNQQVNDEPLVYLDNAATTQKPALVLEALQSYYQEDNANVHRGVHTLAERATLKYEASRQQVADFIH
AKSSKEVLFTRGTTTSLNWVARFAEQVLTPEDEVLISIMEHHANIIPWQQACQKTGARLVYVYLKDGQLDMDDLANKLTT
KTRFVSLVHVSNVLGCINPIKEIAKLAHAKGAYLVVDGAQSVPHLAIDVQDLDCDFFAFSAHKMLGPTGLGVLYGKEELL
NQVEPLEFGGEMIDFVYEQEATWKELPWKFEAGTPHIAGAIGLSAAISYLQRLGMADIHAHEAELIAYVLPKLEAIEGLT
IYGPSQPSARSGLISFNLDDLHPHDLATALDYEGVAVRAGHHCAQPLLSYLGVPATVRASFYIYNTKADCDRLVEAILKA
KEFFNGTL
>Mature_408_residues
MLDAKDIKQDFQILNQQVNDEPLVYLDNAATTQKPALVLEALQSYYQEDNANVHRGVHTLAERATLKYEASRQQVADFIH
AKSSKEVLFTRGTTTSLNWVARFAEQVLTPEDEVLISIMEHHANIIPWQQACQKTGARLVYVYLKDGQLDMDDLANKLTT
KTRFVSLVHVSNVLGCINPIKEIAKLAHAKGAYLVVDGAQSVPHLAIDVQDLDCDFFAFSAHKMLGPTGLGVLYGKEELL
NQVEPLEFGGEMIDFVYEQEATWKELPWKFEAGTPHIAGAIGLSAAISYLQRLGMADIHAHEAELIAYVLPKLEAIEGLT
IYGPSQPSARSGLISFNLDDLHPHDLATALDYEGVAVRAGHHCAQPLLSYLGVPATVRASFYIYNTKADCDRLVEAILKA
KEFFNGTL

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI156713448, Length=259, Percent_Identity=26.2548262548263, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787970, Length=402, Percent_Identity=46.7661691542289, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1789175, Length=386, Percent_Identity=44.8186528497409, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI48994898, Length=230, Percent_Identity=28.695652173913, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=232, Percent_Identity=31.4655172413793, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193211090, Length=385, Percent_Identity=26.7532467532467, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6319831, Length=228, Percent_Identity=30.2631578947368, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI20129463, Length=241, Percent_Identity=31.1203319502075, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45160; Mature: 45160

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAKDIKQDFQILNQQVNDEPLVYLDNAATTQKPALVLEALQSYYQEDNANVHRGVHTL
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AERATLKYEASRQQVADFIHAKSSKEVLFTRGTTTSLNWVARFAEQVLTPEDEVLISIME
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
HHANIIPWQQACQKTGARLVYVYLKDGQLDMDDLANKLTTKTRFVSLVHVSNVLGCINPI
HCCCCCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIAKLAHAKGAYLVVDGAQSVPHLAIDVQDLDCDFFAFSAHKMLGPTGLGVLYGKEELL
HHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCEEEEHHHHHCCCCCCEEEECHHHHH
NQVEPLEFGGEMIDFVYEQEATWKELPWKFEAGTPHIAGAIGLSAAISYLQRLGMADIHA
HHCCCHHHCCHHHHHHHHCCCCHHHCCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
HEAELIAYVLPKLEAIEGLTIYGPSQPSARSGLISFNLDDLHPHDLATALDYEGVAVRAG
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEECC
HHCAQPLLSYLGVPATVRASFYIYNTKADCDRLVEAILKAKEFFNGTL
HHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDAKDIKQDFQILNQQVNDEPLVYLDNAATTQKPALVLEALQSYYQEDNANVHRGVHTL
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AERATLKYEASRQQVADFIHAKSSKEVLFTRGTTTSLNWVARFAEQVLTPEDEVLISIME
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
HHANIIPWQQACQKTGARLVYVYLKDGQLDMDDLANKLTTKTRFVSLVHVSNVLGCINPI
HCCCCCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIAKLAHAKGAYLVVDGAQSVPHLAIDVQDLDCDFFAFSAHKMLGPTGLGVLYGKEELL
HHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCEEEEHHHHHCCCCCCEEEECHHHHH
NQVEPLEFGGEMIDFVYEQEATWKELPWKFEAGTPHIAGAIGLSAAISYLQRLGMADIHA
HHCCCHHHCCHHHHHHHHCCCCHHHCCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
HEAELIAYVLPKLEAIEGLTIYGPSQPSARSGLISFNLDDLHPHDLATALDYEGVAVRAG
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEECC
HHCAQPLLSYLGVPATVRASFYIYNTKADCDRLVEAILKAKEFFNGTL
HHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]