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The map label for this gene is mecA

Identifier: 15674458

GI number: 15674458

Start: 246522

End: 247283

Strand: Direct

Name: mecA

Synonym: SPy_0281

Alternate gene names: 15674458

Gene position: 246522-247283 (Clockwise)

Preceding gene: 15674457

Following gene: 15674459

Centisome position: 13.31

GC content: 36.61

Gene sequence:

>762_bases
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAACGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Upstream 100 bases:

>100_bases
GCTTTTTAAATTTCCTTTTGTAGACGAGGAGTTAGTCATAAATTGCGAAATTACAGCATTTCTAGTATAATAAAATGACT
ACGCGTGCGAGGTATTGAGA

Downstream 100 bases:

>100_bases
AATAGTATGTTTTCATTCACAATAGATTATGTCCTTGTTCTGATAGGGGCTTTGTTAATGTCCTTATTCTTAACCCCTCT
TGTTCGCTTTTTAGCCTTTC

Product: adaptor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Sequences:

>Translated_253_residues
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG
>Mature_253_residues
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Specific function: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis

COG id: COG4862

COG function: function code OTN; Negative regulator of genetic competence, sporulation and motility

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mecA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MECA_STRP1 (P60187)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268632.1
- RefSeq:   YP_281603.1
- ProteinModelPortal:   P60187
- EnsemblBacteria:   EBSTRT00000000933
- EnsemblBacteria:   EBSTRT00000028372
- GeneID:   3572667
- GeneID:   900578
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0281
- KEGG:   spz:M5005_Spy_0239
- GeneTree:   EBGT00050000027374
- HOGENOM:   HBG697243
- OMA:   VFVTKSD
- ProtClustDB:   PRK02315
- BioCyc:   SPYO160490:SPY0281-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0239-MONOMER
- HAMAP:   MF_01124
- InterPro:   IPR008681
- PIRSF:   PIRSF029008

Pfam domain/function: PF05389 MecA

EC number: NA

Molecular weight: Translated: 29052; Mature: 29052

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGML
CCCHHHCCCEEEEEEEECCHHHCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEE
SFRVTPRKDRLDVFVTKSEINKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAH
EEEECCCCCCEEEEEEHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHH
EKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVHYVLDFSTITEAVAFAKTIDF
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
CEEHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEE
DGAVEQLQKIELG
HHHHHHHHHHCCC
>Mature Secondary Structure
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGML
CCCHHHCCCEEEEEEEECCHHHCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEE
SFRVTPRKDRLDVFVTKSEINKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAH
EEEECCCCCCEEEEEEHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHH
EKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVHYVLDFSTITEAVAFAKTIDF
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
CEEHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEE
DGAVEQLQKIELG
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296