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The map label for this gene is nadC [H]

Identifier: 15674399

GI number: 15674399

Start: 180951

End: 181823

Strand: Direct

Name: nadC [H]

Synonym: SPy_0197

Alternate gene names: 15674399

Gene position: 180951-181823 (Clockwise)

Preceding gene: 15674396

Following gene: 15674403

Centisome position: 9.77

GC content: 42.04

Gene sequence:

>873_bases
ATGTCAATCATTTCAACTGATTTAACCCCTTTTCAAATAGATGATACATTGAAAGCAGCCTTGCGAGAAGATGTTCATTC
CGAAGATTACAGTACCAATGCCATTTTTGATCATCATGGCCAAGCCAAGGTGTCGCTTTTTGCCAAGGAAGCTGGTGTTT
TAGCGGGGCTAACCGTTTTTCAAAGGGTTTTTACCCTATTTGATACTGAGGTGACCTTCCAGAATCCTCATCAATTTAAG
GATGGGGATCGTTTGACTAGTGGCGATTTGGTTTTAGAAATCATAGGCTCGGTGAGAAGCCTCTTAACATGTGAACGCGT
TGCCTTGAATTTTTTACAACATTTATCAGGGATTGCTTCGATGACAGCTGCTTATGTAGAAGCCTTAGGCGATGATCGCA
TTAAGGTATTTGATACTCGAAAAACCACTCCTAATTTACGTCTTTTTGAGAAATATGCCGTGAGAGTTGGCGGTGGCTAT
AATCATCGCTTTAATTTATCAGATGCTATCATGCTAAAAGACAATCACATTGCGGCAGTAGGTAGTGTTCAAAAGGCGAT
TGCTCAAGCGCGTGCCTATGCCCCTTTTGTGAAAATGGTCGAGGTGGAAGTGGAAAGCCTTGCTGCTGCCGAAGAAGCTG
CGGCGGCGGGTGTTGATATTATCATGTTGGATAATATGTCATTGGAACAGATTGAACAGGCCATTACTCTAATTGCAGGA
CGTTCTCGGATTGAATGTTCTGGAAATATTGATATGACCACTATTAGCCGTTTTCGTGGTTTAGCGATTGATTACGTCTC
CAGTGGTAGTTTAACCCATAGTGCTAAGAGTCTCGATTTTTCCATGAAGGGTTTAACCTACCTTGATGTCTAA

Upstream 100 bases:

>100_bases
GGGATTTAAAATGAGGTATTCAGGTTTGTGATTTCCTACGGAAGTTAATAGCAATTGCCTCTAGTGCTTACAAGTGATAT
TAAAAATAGAGGACTTAGTG

Downstream 100 bases:

>100_bases
GTTGCAAAATAAACTAACTTTTTAAAGGATGTCTTTCCTCTAGAACGAGTTTTATGTCAGATAGTTTAAACGCCTTTTCA
AATACTTTCCCTGTTTTCAC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDTEVTFQNPHQFK
DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY
NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV

Sequences:

>Translated_290_residues
MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDTEVTFQNPHQFK
DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY
NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
>Mature_289_residues
SIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDTEVTFQNPHQFKD
GDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYN
HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAGR
SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=281, Percent_Identity=40.2135231316726, Blast_Score=178, Evalue=5e-45,
Organism=Escherichia coli, GI1786299, Length=278, Percent_Identity=39.568345323741, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=277, Percent_Identity=35.0180505415162, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31733; Mature: 31601

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
CCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEEHHCCHHHHHHHH
QRVFTLFDTEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
HHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHEECCCCCCEECCCCEEEEECCCEEEH
GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHC
RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
CCEEEECCCCCHHHHHHHCCEEEEEECCCCCCCCHHHCCEEECCEEEECC
>Mature Secondary Structure 
SIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVF
CCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEEHHCCHHHHHHHH
QRVFTLFDTEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIAS
HHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAV
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHEECCCCCCEECCCCEEEEECCCEEEH
GSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHC
RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
CCEEEECCCCCHHHHHHHCCEEEEEECCCCCCCCHHHCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]