Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is purB [H]

Identifier: 15674278

GI number: 15674278

Start: 51282

End: 52574

Strand: Direct

Name: purB [H]

Synonym: SPy_0036

Alternate gene names: 15674278

Gene position: 51282-52574 (Clockwise)

Preceding gene: 15674277

Following gene: 15674279

Centisome position: 2.77

GC content: 44.93

Gene sequence:

>1293_bases
ATGCTAGAACGTTATTCACGCCCTGAGATGGCGGCAATTTGGACAGAGGAAAATAAATACCATGCTTGGTTGGAGGTCGA
GATTTTGGCTGACGAGGCATGGGCTGAGTTGGGTGAGATTCCTAAGGAGGATGTGGCTAAGATTCGTGAGAAGGCGGATT
TTGACATTGACCGCATTCTTGAAATTGAGCAGGACACGCGTCACGATGTGGTGGCTTTCACGCGTGCGGTTTCTGAAACG
CTTGGTGAGGAGCGCAAGTGGGTGCACTACGGTTTGACCTCGACTGACGTGGTGGACACTGCCTATGGTTACCTCTACAA
GCAAGCTAACGACATTATCCGTCGCGATCTTGAGAATTTCACCAATATCGTGGCAGACAAGGCGCGTGAGCACAAAATGA
CCATCATGATGGGTCGTACCCACGGTGTTCACGCCGAGCCAACGACTTTCGGTCTTAAGTTGGCGACTTGGTACAGCGAG
ATGAAACGTAATATTGAGCGTTTTGAACATGCTGCCGCAGGTGTGGAAGCTGGTAAGATTTCAGGTGCCGTTGGTAACTT
TGCCAACATCCCACCTTTTGTGGAAGAATATGTCTGTGACAAATTAGGCATTCGTCCGCAAGAAATTTCAACACAAGTTC
TTCCACGTGACCTTCACGCAGAATATTTTGCAGTGCTTGCAAGTATTGCAACTTCTATCGAACGTATGGCGACAGAGATT
CGAGGTCTGCAAAAGTCAGAACAACGTGAAGTTGAAGAATTCTTTGCCAAAGGTCAGAAAGGTAGCTCTGCTATGCCTCA
CAAACGCAACCCAATCGGTTCAGAGAACATGACAGGGCTAGCGCGCGTGATTCGTGGTCACATGGTGACAGCTTATGAGA
ACGTGTCACTTTGGCATGAGCGTGACATTTCGCACTCATCAGCTGAGCGTATCATCACACCTGACACAACTATCTTGATT
GACTACATGCTCAACCGCTTTGGTAATATCGTTAAGAACTTGACTGTCTTCCCGGAAAATATGATGCGCAATATGGAATC
AACTTTTGGTTTGATTTATAGTCAACGTGTTATGCTCAAATTGATTGAAAAAGGAATGACACGAGAAGAAGCTTATGACT
TAGTTCAACCTAAGACAGCTTATTCCTGGGACAATCAAGTGGATTTCAAACCACTTTTAGAAGAAGACACCAAAGTTACC
TCTTGTCTTACACAAGAAGAAATTGATGAACTATTTAATCCGATTTATTACACAAAACGTGTTGATGATATTTTTAAGCG
TTTAGGGATTTAA

Upstream 100 bases:

>100_bases
AGTTATACCCAGAAGCTTATCCAGCTAATATATTTAAAAATGGTAAACGTACTAAAGAATTAAAAGAAAAAATGTCTTTT
TAATAAGATAAGGGGAAAAA

Downstream 100 bases:

>100_bases
TATAAAAAAAAGAAGGTGATTCCCTTCTTTTTTATTTAAAAAAACGAATATTTTCTTTAAAAATATTAAAAAGGTTAGTT
TTTAATTAGACGCTGTGATA

Product: adenylosuccinate lyase

Products: NA

Alternate protein names: ASL; Adenylosuccinase; ASase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLERYSRPEMAAIWTEENKYHAWLEVEILADEAWAELGEIPKEDVAKIREKADFDIDRILEIEQDTRHDVVAFTRAVSET
LGEERKWVHYGLTSTDVVDTAYGYLYKQANDIIRRDLENFTNIVADKAREHKMTIMMGRTHGVHAEPTTFGLKLATWYSE
MKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCDKLGIRPQEISTQVLPRDLHAEYFAVLASIATSIERMATEI
RGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMVTAYENVSLWHERDISHSSAERIITPDTTILI
DYMLNRFGNIVKNLTVFPENMMRNMESTFGLIYSQRVMLKLIEKGMTREEAYDLVQPKTAYSWDNQVDFKPLLEEDTKVT
SCLTQEEIDELFNPIYYTKRVDDIFKRLGI

Sequences:

>Translated_430_residues
MLERYSRPEMAAIWTEENKYHAWLEVEILADEAWAELGEIPKEDVAKIREKADFDIDRILEIEQDTRHDVVAFTRAVSET
LGEERKWVHYGLTSTDVVDTAYGYLYKQANDIIRRDLENFTNIVADKAREHKMTIMMGRTHGVHAEPTTFGLKLATWYSE
MKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCDKLGIRPQEISTQVLPRDLHAEYFAVLASIATSIERMATEI
RGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMVTAYENVSLWHERDISHSSAERIITPDTTILI
DYMLNRFGNIVKNLTVFPENMMRNMESTFGLIYSQRVMLKLIEKGMTREEAYDLVQPKTAYSWDNQVDFKPLLEEDTKVT
SCLTQEEIDELFNPIYYTKRVDDIFKRLGI
>Mature_430_residues
MLERYSRPEMAAIWTEENKYHAWLEVEILADEAWAELGEIPKEDVAKIREKADFDIDRILEIEQDTRHDVVAFTRAVSET
LGEERKWVHYGLTSTDVVDTAYGYLYKQANDIIRRDLENFTNIVADKAREHKMTIMMGRTHGVHAEPTTFGLKLATWYSE
MKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCDKLGIRPQEISTQVLPRDLHAEYFAVLASIATSIERMATEI
RGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMVTAYENVSLWHERDISHSSAERIITPDTTILI
DYMLNRFGNIVKNLTVFPENMMRNMESTFGLIYSQRVMLKLIEKGMTREEAYDLVQPKTAYSWDNQVDFKPLLEEDTKVT
SCLTQEEIDELFNPIYYTKRVDDIFKRLGI

Specific function: De novo purine biosynthesis; eighth step. [C]

COG id: COG0015

COG function: function code F; Adenylosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557269, Length=446, Percent_Identity=25.5605381165919, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI183227688, Length=398, Percent_Identity=26.8844221105528, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1787376, Length=357, Percent_Identity=28.8515406162465, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17508577, Length=395, Percent_Identity=26.8354430379747, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32564234, Length=350, Percent_Identity=26.5714285714286, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323391, Length=430, Percent_Identity=27.6744186046512, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24647570, Length=391, Percent_Identity=23.5294117647059, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019468
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- InterPro:   IPR004769 [H]

Pfam domain/function: PF10397 ADSL_C; PF00206 Lyase_1 [H]

EC number: =4.3.2.2 [H]

Molecular weight: Translated: 49535; Mature: 49535

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERYSRPEMAAIWTEENKYHAWLEVEILADEAWAELGEIPKEDVAKIREKADFDIDRIL
CCCCCCCCCEEEEEECCCCEEEEEEEEEECHHHHHHHHCCCHHHHHHHHHHCCCCHHHHH
EIEQDTRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAYGYLYKQANDIIRRDLENF
HHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TNIVADKAREHKMTIMMGRTHGVHAEPTTFGLKLATWYSEMKRNIERFEHAAAGVEAGKI
HHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
SGAVGNFANIPPFVEEYVCDKLGIRPQEISTQVLPRDLHAEYFAVLASIATSIERMATEI
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMVTAYENVSLWHE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
RDISHSSAERIITPDTTILIDYMLNRFGNIVKNLTVFPENMMRNMESTFGLIYSQRVMLK
HCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LIEKGMTREEAYDLVQPKTAYSWDNQVDFKPLLEEDTKVTSCLTQEEIDELFNPIYYTKR
HHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VDDIFKRLGI
HHHHHHHHCC
>Mature Secondary Structure
MLERYSRPEMAAIWTEENKYHAWLEVEILADEAWAELGEIPKEDVAKIREKADFDIDRIL
CCCCCCCCCEEEEEECCCCEEEEEEEEEECHHHHHHHHCCCHHHHHHHHHHCCCCHHHHH
EIEQDTRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAYGYLYKQANDIIRRDLENF
HHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TNIVADKAREHKMTIMMGRTHGVHAEPTTFGLKLATWYSEMKRNIERFEHAAAGVEAGKI
HHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
SGAVGNFANIPPFVEEYVCDKLGIRPQEISTQVLPRDLHAEYFAVLASIATSIERMATEI
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMVTAYENVSLWHE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
RDISHSSAERIITPDTTILIDYMLNRFGNIVKNLTVFPENMMRNMESTFGLIYSQRVMLK
HCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LIEKGMTREEAYDLVQPKTAYSWDNQVDFKPLLEEDTKVTSCLTQEEIDELFNPIYYTKR
HHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VDDIFKRLGI
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]