Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is dnaA

Identifier: 15674251

GI number: 15674251

Start: 232

End: 1587

Strand: Direct

Name: dnaA

Synonym: SPy_0002

Alternate gene names: 15674251

Gene position: 232-1587 (Clockwise)

Preceding gene: NA

Following gene: 15674252

Centisome position: 0.01

GC content: 33.41

Gene sequence:

>1356_bases
ATGACTGAAAATGAACAAATTTTTTGGAACAGGGTCTTGGAATTAGCTCAGAGTCAATTAAAACAGGCAACTTATGAATT
TTTTGTTCATGATGCCCGTCTATTAAAGGTCGATAAGCATATTGCAACTATTTACTTAGATCAAATGAAAGAGCTCTTTT
GGGAAAAAAATCTTAAAGATGTTATTCTTACTGCTGGTTTTGAAGTTTATAACGCTCAAATTTCTGTTGACTATGTTTTC
GAAGAAGACCTAATGATTGAGCAAAATCAGACCAAAATCAACCAAAAACCTAAGCAGCAAGCCTTAAATTCTTTGCCTAC
TGTTACTTCAGATTTAAACTCGAAATATAGTTTTGAAAACTTTATTCAAGGAGATGAAAATCGTTGGGCTGTTGCTGCTT
CAATAGCAGTAGCTAATACTCCTGGAACTACCTATAATCCTTTGTTTATTTGGGGTGGCCCTGGGCTTGGAAAAACCCAT
TTATTAAATGCTATTGGTAATTCTGTACTATTAGAAAATCCAAATGCTCGAATTAAATATATCACAGCTGAAAACTTTAT
TAATGAGTTTGTTATCCATATTCGCCTTGATACCATGGATGAATTGAAAGAAAAATTTCGTAATTTAGATTTACTCCTTA
TTGATGATATCCAATCTTTAGCTAAAAAAACGCTCTCTGGAACACAAGAAGAGTTCTTTAATACTTTTAATGCACTTCAT
AATAATAACAAACAAATTGTCCTAACAAGCGACCGTACACCAGATCATCTCAATGATTTAGAAGATCGATTAGTTACTCG
TTTTAAATGGGGATTAACAGTCAATATCACACCTCCTGATTTTGAAACACGAGTGGCTATTTTGACAAATAAAATTCAAG
AATATAACTTTATTTTTCCTCAAGATACCATTGAGTATTTGGCTGGTCAATTTGATTCTAATGTCAGAGATTTAGAAGGT
GCCTTAAAAGATATTAGTCTGGTTGCTAATTTCAAACAAATTGACACGATTACTGTTGACATTGCTGCCGAAGCTATTCG
CGCCAGAAAGCAAGATGGACCTAAAATGACAGTTATTCCCATCGAAGAAATTCAAGCGCAAGTTGGAAAATTTTACGGTG
TTACCGTCAAAGAAATTAAAGCTACTAAACGAACACAAAATATTGTTTTAGCAAGACAAGTAGCTATGTTTTTAGCACGT
GAAATGACAGATAACAGTCTTCCTAAAATTGGAAAAGAATTTGGTGGCAGAGACCATTCAACAGTACTCCATGCCTATAA
TAAAATCAAAAACATGATCAGCCAGGACGAAAGCCTTAGGATCGAAATTGAAACCATAAAAAACAAAATTAAATAA

Upstream 100 bases:

>100_bases
ACAGGTTGTGGAAAAACTAACTATTATCCATCGTTCTGTGGAAAACTAGAATAGTTTATGGTAGAATAGTTCTAGAATTA
TCCACAAGAAGGAACCTAGT

Downstream 100 bases:

>100_bases
CATGTGGAAAAGAATATCTTTTATGAAATAGTTATCCACAAGTTGTGAACATCCATTTAGTCTTGGATTCTCTCGTTTAT
TTAGAGTTATCCACTATATA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATIYLDQMKELFWEKNLKDVILTAGFEVYNAQISVDYVF
EEDLMIEQNQTKINQKPKQQALNSLPTVTSDLNSKYSFENFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTH
LLNAIGNSVLLENPNARIKYITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALH
NNNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEG
ALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQAQVGKFYGVTVKEIKATKRTQNIVLARQVAMFLAR
EMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMISQDESLRIEIETIKNKIK

Sequences:

>Translated_451_residues
MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATIYLDQMKELFWEKNLKDVILTAGFEVYNAQISVDYVF
EEDLMIEQNQTKINQKPKQQALNSLPTVTSDLNSKYSFENFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTH
LLNAIGNSVLLENPNARIKYITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALH
NNNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEG
ALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQAQVGKFYGVTVKEIKATKRTQNIVLARQVAMFLAR
EMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMISQDESLRIEIETIKNKIK
>Mature_450_residues
TENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATIYLDQMKELFWEKNLKDVILTAGFEVYNAQISVDYVFE
EDLMIEQNQTKINQKPKQQALNSLPTVTSDLNSKYSFENFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHL
LNAIGNSVLLENPNARIKYITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHN
NNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEGA
LKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQAQVGKFYGVTVKEIKATKRTQNIVLARQVAMFLARE
MTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMISQDESLRIEIETIKNKIK

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=342, Percent_Identity=46.4912280701754, Blast_Score=306, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_STRP1 (P0A3A4)

Other databases:

- EMBL:   AF255728
- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268424.1
- RefSeq:   YP_281365.1
- ProteinModelPortal:   P0A3A4
- EnsemblBacteria:   EBSTRT00000001273
- EnsemblBacteria:   EBSTRT00000027765
- GeneID:   3571011
- GeneID:   900904
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0002
- KEGG:   spz:M5005_Spy_0001
- GeneTree:   EBGT00050000028345
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   SPYO160490:SPY0002-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51666; Mature: 51534

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATIYLDQMKELFWEKNLKD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VILTAGFEVYNAQISVDYVFEEDLMIEQNQTKINQKPKQQALNSLPTVTSDLNSKYSFEN
HHHCCCCEEEEEEEEEEEEECCCEEEECCCHHHCCCHHHHHHHHCCCHHHHCCCCCCHHH
FIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHLLNAIGNSVLLENPNARIKY
HHCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEECCCCCEEE
ITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALH
EEHHHHHHHEEEEEEECCHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHH
NNNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFP
CCCCEEEEECCCCCHHHHHHHHHHHHHEECCEEEEECCCCCHHHHHHHHHHHHHCCEECC
QDTIEYLAGQFDSNVRDLEGALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHCEEEEHHHHHHHHHHHCCCCEEEEEE
IEEIQAQVGKFYGVTVKEIKATKRTQNIVLARQVAMFLAREMTDNSLPKIGKEFGGRDHS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHH
TVLHAYNKIKNMISQDESLRIEIETIKNKIK
HHHHHHHHHHHHHCCCCCEEEEEEHHHCCCC
>Mature Secondary Structure 
TENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATIYLDQMKELFWEKNLKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VILTAGFEVYNAQISVDYVFEEDLMIEQNQTKINQKPKQQALNSLPTVTSDLNSKYSFEN
HHHCCCCEEEEEEEEEEEEECCCEEEECCCHHHCCCHHHHHHHHCCCHHHHCCCCCCHHH
FIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHLLNAIGNSVLLENPNARIKY
HHCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEECCCCCEEE
ITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALH
EEHHHHHHHEEEEEEECCHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHH
NNNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFP
CCCCEEEEECCCCCHHHHHHHHHHHHHEECCEEEEECCCCCHHHHHHHHHHHHHCCEECC
QDTIEYLAGQFDSNVRDLEGALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHCEEEEHHHHHHHHHHHCCCCEEEEEE
IEEIQAQVGKFYGVTVKEIKATKRTQNIVLARQVAMFLAREMTDNSLPKIGKEFGGRDHS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHH
TVLHAYNKIKNMISQDESLRIEIETIKNKIK
HHHHHHHHHHHHHCCCCCEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10930754; 11296296