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The map label for this gene is hisC3

Identifier: 13474816

GI number: 13474816

Start: 4666145

End: 4667254

Strand: Direct

Name: hisC3

Synonym: mlr5786

Alternate gene names: 13474816

Gene position: 4666145-4667254 (Clockwise)

Preceding gene: 13474815

Following gene: 13474817

Centisome position: 66.32

GC content: 51.71

Gene sequence:

>1110_bases
ATGTCCGATGCAAAACTTCAGAGTGTGCTGTCGTCTCTTTCGCAAGTGGCGAGACAGTTAGATGCTCTGCCATCCGATAC
ACCAGCGCCGGATTCAAGTTGGGTAAAACTAAACACGAATGAGAACCCCTTCCCGCTTCCGGAAATCATAATGCAAAGTG
CGATTGCAGCTCTCGAACGGCAGTATCTATATCCAGAAGACGATAACATCAGCTTGAGAGAAGCAGCCGCGAATGCCTAC
AGCGTCTCCATGGATCAGGTGATCGCCGGCAACGGATCGTCTGAACTGCTTGGACTTGTCTACAGAGCATTCCTTACCCC
GGGGGATAGCGTGGCGATGATGTCGCCAGGTTTTTCGTTCAACCGCAAACTTGCAACGTTGCAGGGTGCTCAATTTGTCG
AAATCGAATTTAGCAAAGATCATTCCTTGCCGATGGAGCAATTGCTCTTCGGTCCTGCAAAGGACGCCAAGTTCATTCTG
CTAGCCAATCCGAACAATCCGACTGGAACGTTCGTTCCGGTGGCCGATATCGAACGCCTGGTAGCGAAATCGGACCGCTT
GATCGTGCTGGATGAGGCCTACGTCGACTTTGCACCCGAGAATGGTCTACGCCTCATCAATCGCTATTCGAACCTTCTGG
TCTTAAGGACATTTTCGAAAAGCTATGCTGCCGCCGGCGTTCGCGTCGGTTTCGGTTTCGGTCATCCTGAAATTATCGGC
AGGCTACGCAACATCCAGAACGTCTTCAACATGAATGTGATCGGGCAGGCGGTTGGTATCAGCGTCCTTGCGCACCGCGC
CGCCTATGCAGACAACCACAGACACATCAGGCATGAACGACGGCGAGTGACGCTCGCGCTGTCGCAACTTGGATTTTCCG
TAATCCCTTCCCACGCAAACTTCTTGCTTGCCCGCGTGCCAACGGCACAGGACGGCTCATGGTGGCAATCAGCCTTCGCA
AGGCAAAAAATACTTGTTGCCGTCTTTCCAGATAAAGGTTTGGAAAATTACATCCGCGTCAGCATCGGTACAAAAGAGCA
AATGGATGCGTTTCTTCGTGCCGCTAGTCGTATTAGCAGAATATTGAATATGTCAACACCCCCGCGTTAG

Upstream 100 bases:

>100_bases
AATGTGCTGACAACGGCGGTGTGAATGCACTGTTGGTCGGCCATGTGCTCAGACCATCAGTTCATCCCGGATTCCCTCTG
CGACTGAAACGGAGAAAAAC

Downstream 100 bases:

>100_bases
GCTGCTAAGGCTCTGCTTTAGCATTTCGCAGCCAATAATCCGAGCGATTACACGAGCGAGAAATCTTTAAATTGCTTGGA
ATACGCAAGCAACCGTACTT

Product: aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 3

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSDAKLQSVLSSLSQVARQLDALPSDTPAPDSSWVKLNTNENPFPLPEIIMQSAIAALERQYLYPEDDNISLREAAANAY
SVSMDQVIAGNGSSELLGLVYRAFLTPGDSVAMMSPGFSFNRKLATLQGAQFVEIEFSKDHSLPMEQLLFGPAKDAKFIL
LANPNNPTGTFVPVADIERLVAKSDRLIVLDEAYVDFAPENGLRLINRYSNLLVLRTFSKSYAAAGVRVGFGFGHPEIIG
RLRNIQNVFNMNVIGQAVGISVLAHRAAYADNHRHIRHERRRVTLALSQLGFSVIPSHANFLLARVPTAQDGSWWQSAFA
RQKILVAVFPDKGLENYIRVSIGTKEQMDAFLRAASRISRILNMSTPPR

Sequences:

>Translated_369_residues
MSDAKLQSVLSSLSQVARQLDALPSDTPAPDSSWVKLNTNENPFPLPEIIMQSAIAALERQYLYPEDDNISLREAAANAY
SVSMDQVIAGNGSSELLGLVYRAFLTPGDSVAMMSPGFSFNRKLATLQGAQFVEIEFSKDHSLPMEQLLFGPAKDAKFIL
LANPNNPTGTFVPVADIERLVAKSDRLIVLDEAYVDFAPENGLRLINRYSNLLVLRTFSKSYAAAGVRVGFGFGHPEIIG
RLRNIQNVFNMNVIGQAVGISVLAHRAAYADNHRHIRHERRRVTLALSQLGFSVIPSHANFLLARVPTAQDGSWWQSAFA
RQKILVAVFPDKGLENYIRVSIGTKEQMDAFLRAASRISRILNMSTPPR
>Mature_368_residues
SDAKLQSVLSSLSQVARQLDALPSDTPAPDSSWVKLNTNENPFPLPEIIMQSAIAALERQYLYPEDDNISLREAAANAYS
VSMDQVIAGNGSSELLGLVYRAFLTPGDSVAMMSPGFSFNRKLATLQGAQFVEIEFSKDHSLPMEQLLFGPAKDAKFILL
ANPNNPTGTFVPVADIERLVAKSDRLIVLDEAYVDFAPENGLRLINRYSNLLVLRTFSKSYAAAGVRVGFGFGHPEIIGR
LRNIQNVFNMNVIGQAVGISVLAHRAAYADNHRHIRHERRRVTLALSQLGFSVIPSHANFLLARVPTAQDGSWWQSAFAR
QKILVAVFPDKGLENYIRVSIGTKEQMDAFLRAASRISRILNMSTPPR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=321, Percent_Identity=26.791277258567, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322075, Length=288, Percent_Identity=27.7777777777778, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS83_RHILO (Q98B00)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106386.1
- ProteinModelPortal:   Q98B00
- GeneID:   1229045
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5786
- NMPDR:   fig|266835.1.peg.4489
- HOGENOM:   HBG646350
- OMA:   KREENDM
- ProtClustDB:   CLSK506468
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40711; Mature: 40580

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAKLQSVLSSLSQVARQLDALPSDTPAPDSSWVKLNTNENPFPLPEIIMQSAIAALER
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
QYLYPEDDNISLREAAANAYSVSMDQVIAGNGSSELLGLVYRAFLTPGDSVAMMSPGFSF
HCCCCCCCCCCHHHHHCCHHEEEHHHEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
NRKLATLQGAQFVEIEFSKDHSLPMEQLLFGPAKDAKFILLANPNNPTGTFVPVADIERL
CCCCEEECCCEEEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHHHHH
VAKSDRLIVLDEAYVDFAPENGLRLINRYSNLLVLRTFSKSYAAAGVRVGFGFGHPEIIG
HHCCCCEEEEECHHCCCCCCCCHHHHHHHCCEEEEEECCHHHHHCCEEEECCCCCHHHHH
RLRNIQNVFNMNVIGQAVGISVLAHRAAYADNHRHIRHERRRVTLALSQLGFSVIPSHAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
FLLARVPTAQDGSWWQSAFARQKILVAVFPDKGLENYIRVSIGTKEQMDAFLRAASRISR
EEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
ILNMSTPPR
HHCCCCCCC
>Mature Secondary Structure 
SDAKLQSVLSSLSQVARQLDALPSDTPAPDSSWVKLNTNENPFPLPEIIMQSAIAALER
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
QYLYPEDDNISLREAAANAYSVSMDQVIAGNGSSELLGLVYRAFLTPGDSVAMMSPGFSF
HCCCCCCCCCCHHHHHCCHHEEEHHHEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
NRKLATLQGAQFVEIEFSKDHSLPMEQLLFGPAKDAKFILLANPNNPTGTFVPVADIERL
CCCCEEECCCEEEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHHHHH
VAKSDRLIVLDEAYVDFAPENGLRLINRYSNLLVLRTFSKSYAAAGVRVGFGFGHPEIIG
HHCCCCEEEEECHHCCCCCCCCHHHHHHHCCEEEEEECCHHHHHCCEEEECCCCCHHHHH
RLRNIQNVFNMNVIGQAVGISVLAHRAAYADNHRHIRHERRRVTLALSQLGFSVIPSHAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
FLLARVPTAQDGSWWQSAFARQKILVAVFPDKGLENYIRVSIGTKEQMDAFLRAASRISR
EEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
ILNMSTPPR
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968