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The map label for this gene is licA [H]

Identifier: 13474477

GI number: 13474477

Start: 4289891

End: 4291135

Strand: Reverse

Name: licA [H]

Synonym: mll5370

Alternate gene names: 13474477

Gene position: 4291135-4289891 (Counterclockwise)

Preceding gene: 13474479

Following gene: 13474476

Centisome position: 60.99

GC content: 62.65

Gene sequence:

>1245_bases
GTGCTTTCGGGCAAAACACCCAAAAAAAGTCACATCTTTTTATTGACAACCGGGCAACCCTGGCGTGAAATCCAGGGCAT
CAGCAGGGGTTCGGAGCTGCAACGGGAGGGCGATGGCAGAGCCGCAACTCACTGGCCAGGCGGTCTTGAACGCGTCTGGC
GCAAGGAATTTTCAGATCCGCGGGGGCGGATGCCGGGATCAAAATCCTGGCCAAGGGGCTCGTCGGTGCGGTGCGGGATA
CCGATCCTGGCGTCCCGCACCGACGAGATTATTTGCGTTTCTCCCCGCTCTCGTCGCGCTGTCCATGGCGCCTTGTCGAA
GCCCAGCAAACCAGGCCAGCAAACCAGGGATGATCCCGTGATTGCCGAAGATCGCATCTGCGCCCTGCCGTGCTGGATCG
GCGCCATCGAGATCGCCCCCCTGCCCGGCGGCCTGAGCAACGCCAATTATGTGGTCAGCGACGCTGCCGGGAAACATGTC
GTGCGCTTCGGCCAGGACTACCCCTTCCACCATGTCTTCCGCGAGCGCGAGGTGATGACCGCGCGGGCGGCCCATGCCGC
CGGCTTCGCGCCGGCCGTGCACTATTCCGAGCCCGGCATCCTGGTGACGCAGTTTCTCGGCGCCAGGACCTTCCTCGCCG
AAGACGTGCGCGCCAATCTCGGCCGTGTGGCGGCGCTGCTGCGATCCTTCCATCGCGAGATGCCGAACCATGTCTCCGGC
GCCGGCTTCATGTTCTGGGTGTTCCACGTCATCCGCGACTATGCGCGCACGCTCGAGGAAGGCAACAGCCGCAAGCGCAG
CGACTTGCCGCGTCTGCTAACGCTGGCTGATGAGCTGGAGCGGGCGCAGAAATTGCTGCCGATCGTCTTCGGCCACAATG
ATCTTTTGCCAGCCAACATTCTCGACGACGGCAACAGGCTGTGGCTGATCGATTTCGAATATGCCGGCTTCAACACGGCA
ATGTTCGACCTTGCCGGCGTCGCCTCGAACGCCGGGATGAGCGACGAGGAATCCTTCGCCTTCCTGACCGCCTATTTCAT
GAAGGAGCCGGACGCGGCGATCCGCCGCTCGCACGCTGCCATGCAATGCGCCTCGCTGTTGCGCGAGGCGATGTGGAGCA
TGGTGTCGGAACTCTATCTCGACGCGCCCGGCATCGACTACGTCGCCTACACCGAGGAAAACCTCGTGCGGCTCGACGCG
GCGCTGGAAAACTACCGGACAAAATACGGGATCCTGAAACCATGA

Upstream 100 bases:

>100_bases
GGATCTCGCCGTGGCGTTTGGAATGGACCATTAGGGTTTCCCGGACTTCGCCTTTTGACCGGTTTTAAGGTAATTCAAGC
ACTTTTAAAGATATCGTCCC

Downstream 100 bases:

>100_bases
CCTTGCCTAGCCATGCCGCCATCGTCGTCATCGGCGGCGGCATCATCGGCTGCTCGACGGCCTATCATCTGGCGCGCGAC
CACAAGGCAAACGTCGTGCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MLSGKTPKKSHIFLLTTGQPWREIQGISRGSELQREGDGRAATHWPGGLERVWRKEFSDPRGRMPGSKSWPRGSSVRCGI
PILASRTDEIICVSPRSRRAVHGALSKPSKPGQQTRDDPVIAEDRICALPCWIGAIEIAPLPGGLSNANYVVSDAAGKHV
VRFGQDYPFHHVFREREVMTARAAHAAGFAPAVHYSEPGILVTQFLGARTFLAEDVRANLGRVAALLRSFHREMPNHVSG
AGFMFWVFHVIRDYARTLEEGNSRKRSDLPRLLTLADELERAQKLLPIVFGHNDLLPANILDDGNRLWLIDFEYAGFNTA
MFDLAGVASNAGMSDEESFAFLTAYFMKEPDAAIRRSHAAMQCASLLREAMWSMVSELYLDAPGIDYVAYTEENLVRLDA
ALENYRTKYGILKP

Sequences:

>Translated_414_residues
MLSGKTPKKSHIFLLTTGQPWREIQGISRGSELQREGDGRAATHWPGGLERVWRKEFSDPRGRMPGSKSWPRGSSVRCGI
PILASRTDEIICVSPRSRRAVHGALSKPSKPGQQTRDDPVIAEDRICALPCWIGAIEIAPLPGGLSNANYVVSDAAGKHV
VRFGQDYPFHHVFREREVMTARAAHAAGFAPAVHYSEPGILVTQFLGARTFLAEDVRANLGRVAALLRSFHREMPNHVSG
AGFMFWVFHVIRDYARTLEEGNSRKRSDLPRLLTLADELERAQKLLPIVFGHNDLLPANILDDGNRLWLIDFEYAGFNTA
MFDLAGVASNAGMSDEESFAFLTAYFMKEPDAAIRRSHAAMQCASLLREAMWSMVSELYLDAPGIDYVAYTEENLVRLDA
ALENYRTKYGILKP
>Mature_414_residues
MLSGKTPKKSHIFLLTTGQPWREIQGISRGSELQREGDGRAATHWPGGLERVWRKEFSDPRGRMPGSKSWPRGSSVRCGI
PILASRTDEIICVSPRSRRAVHGALSKPSKPGQQTRDDPVIAEDRICALPCWIGAIEIAPLPGGLSNANYVVSDAAGKHV
VRFGQDYPFHHVFREREVMTARAAHAAGFAPAVHYSEPGILVTQFLGARTFLAEDVRANLGRVAALLRSFHREMPNHVSG
AGFMFWVFHVIRDYARTLEEGNSRKRSDLPRLLTLADELERAQKLLPIVFGHNDLLPANILDDGNRLWLIDFEYAGFNTA
MFDLAGVASNAGMSDEESFAFLTAYFMKEPDAAIRRSHAAMQCASLLREAMWSMVSELYLDAPGIDYVAYTEENLVRLDA
ALENYRTKYGILKP

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 46092; Mature: 46092

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSGKTPKKSHIFLLTTGQPWREIQGISRGSELQREGDGRAATHWPGGLERVWRKEFSDP
CCCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHCCCC
RGRMPGSKSWPRGSSVRCGIPILASRTDEIICVSPRSRRAVHGALSKPSKPGQQTRDDPV
CCCCCCCCCCCCCCCCEECCCCEECCCCCEEEECCCCCHHHHHHCCCCCCCCCCCCCCCC
IAEDRICALPCWIGAIEIAPLPGGLSNANYVVSDAAGKHVVRFGQDYPFHHVFREREVMT
CCCCCEEEEEHHHCEEEEECCCCCCCCCCEEEECCCCCHHHHCCCCCCHHHHHHHHHHHH
ARAAHAAGFAPAVHYSEPGILVTQFLGARTFLAEDVRANLGRVAALLRSFHREMPNHVSG
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGFMFWVFHVIRDYARTLEEGNSRKRSDLPRLLTLADELERAQKLLPIVFGHNDLLPANI
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCE
LDDGNRLWLIDFEYAGFNTAMFDLAGVASNAGMSDEESFAFLTAYFMKEPDAAIRRSHAA
ECCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
MQCASLLREAMWSMVSELYLDAPGIDYVAYTEENLVRLDAALENYRTKYGILKP
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLSGKTPKKSHIFLLTTGQPWREIQGISRGSELQREGDGRAATHWPGGLERVWRKEFSDP
CCCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHCCCC
RGRMPGSKSWPRGSSVRCGIPILASRTDEIICVSPRSRRAVHGALSKPSKPGQQTRDDPV
CCCCCCCCCCCCCCCCEECCCCEECCCCCEEEECCCCCHHHHHHCCCCCCCCCCCCCCCC
IAEDRICALPCWIGAIEIAPLPGGLSNANYVVSDAAGKHVVRFGQDYPFHHVFREREVMT
CCCCCEEEEEHHHCEEEEECCCCCCCCCCEEEECCCCCHHHHCCCCCCHHHHHHHHHHHH
ARAAHAAGFAPAVHYSEPGILVTQFLGARTFLAEDVRANLGRVAALLRSFHREMPNHVSG
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGFMFWVFHVIRDYARTLEEGNSRKRSDLPRLLTLADELERAQKLLPIVFGHNDLLPANI
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCE
LDDGNRLWLIDFEYAGFNTAMFDLAGVASNAGMSDEESFAFLTAYFMKEPDAAIRRSHAA
ECCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
MQCASLLREAMWSMVSELYLDAPGIDYVAYTEENLVRLDAALENYRTKYGILKP
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]