Click here to switch to the map view.

The map label for this gene is licA [H]

Identifier: 13474474

GI number: 13474474

Start: 4285806

End: 4286708

Strand: Reverse

Name: licA [H]

Synonym: mll5367

Alternate gene names: 13474474

Gene position: 4286708-4285806 (Counterclockwise)

Preceding gene: 13474476

Following gene: 13474470

Centisome position: 60.92

GC content: 64.89

Gene sequence:

>903_bases
ATGATGACGGACGAAGCGCGGGCGAAGCTGGCCGCCATTCCCATGCTGGCCGGCTACACCGGGCCGCTGGAACGGCTCGG
CGGCCTTACCAATCTCGTCTTCAGGGCCGGCGATCTCTGCCTGCGCATCCCAGGCAAAGGCACCGAGGAATATATCAACC
GCGCCAACGAAGCGGTGGCCGCGCGCGAAGCGGCAAAGGCGGGGGTCAGTCCCGAGGTGCTGCATGTCGATCCCGCCACC
GGGGTCATGGTGACGCGCTACATCGCGGGCGCGCAGACCATGTCGCCGGAGAAATTCAAGACACGACCGGGCAGTCCCGC
CCGGGCCGGCGAAGCCTTCCGCAAGCTGCACGGGTCCGGTGCGGTGTTCCCCTTCCGCTTCGAACTTTTCGCGATGATCG
ACGACTATCTCAAGGTGCTGTCGACCAAGAACGTCACCCTGCCTGCCGGCTATCACGACGTGGTGCGCGAGGCCGGCGGC
GTGCGCTCCGCGCTTGCCGCTCATCCGCTGCCGCTTGCCGCCTGCCATTGCGATCCGCTGTGCGAGAACTTCCTCGATAC
GGGCGAGCGGATGTGGATCGTCGACTGGGAATATTCGGGGATGAACGACCCGCTCTGGGATCTCGGCGACCTCAGCGTGG
AAGGCAAGTTCAATGCGAACCAGGACGAAGAGCTGATGCGCGCTTATTTCGGCGGCGAAGCGAGGCCGGCGGAGCGCGGC
CGCGTCGTCATCTACAAGGCCATGTGCGATCTGCTCTGGACGCTGTGGGGGCTGATCCAGCTTGCCAACGACAATCCCGT
CGACGATTTCCGCGCCTATGCGGACGGCCGCTTCGCCCGCTGCAAGGCGTTGATGGAGACGCCGGAGTTTTCACGGCATT
TGGCTGCTGTGCGTATGGGTTAG

Upstream 100 bases:

>100_bases
TGCTGTGTCGCCTGATCGAGTTGCCTTTGATCCGATGATAGCCAAACGACGAAAATTGTGGAACCGTTGCCGTGAGAAAT
AACGGCGTGGGGGCGCGGGC

Downstream 100 bases:

>100_bases
CGCAATTCCATATGACAGCAGCTCCAGTTCACCTGAAAACCCTCTCTATCTCGCTCAACGTCACTGTATCGTCAGACTTT
TTGCAATACCAAATGATCAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MMTDEARAKLAAIPMLAGYTGPLERLGGLTNLVFRAGDLCLRIPGKGTEEYINRANEAVAAREAAKAGVSPEVLHVDPAT
GVMVTRYIAGAQTMSPEKFKTRPGSPARAGEAFRKLHGSGAVFPFRFELFAMIDDYLKVLSTKNVTLPAGYHDVVREAGG
VRSALAAHPLPLAACHCDPLCENFLDTGERMWIVDWEYSGMNDPLWDLGDLSVEGKFNANQDEELMRAYFGGEARPAERG
RVVIYKAMCDLLWTLWGLIQLANDNPVDDFRAYADGRFARCKALMETPEFSRHLAAVRMG

Sequences:

>Translated_300_residues
MMTDEARAKLAAIPMLAGYTGPLERLGGLTNLVFRAGDLCLRIPGKGTEEYINRANEAVAAREAAKAGVSPEVLHVDPAT
GVMVTRYIAGAQTMSPEKFKTRPGSPARAGEAFRKLHGSGAVFPFRFELFAMIDDYLKVLSTKNVTLPAGYHDVVREAGG
VRSALAAHPLPLAACHCDPLCENFLDTGERMWIVDWEYSGMNDPLWDLGDLSVEGKFNANQDEELMRAYFGGEARPAERG
RVVIYKAMCDLLWTLWGLIQLANDNPVDDFRAYADGRFARCKALMETPEFSRHLAAVRMG
>Mature_300_residues
MMTDEARAKLAAIPMLAGYTGPLERLGGLTNLVFRAGDLCLRIPGKGTEEYINRANEAVAAREAAKAGVSPEVLHVDPAT
GVMVTRYIAGAQTMSPEKFKTRPGSPARAGEAFRKLHGSGAVFPFRFELFAMIDDYLKVLSTKNVTLPAGYHDVVREAGG
VRSALAAHPLPLAACHCDPLCENFLDTGERMWIVDWEYSGMNDPLWDLGDLSVEGKFNANQDEELMRAYFGGEARPAERG
RVVIYKAMCDLLWTLWGLIQLANDNPVDDFRAYADGRFARCKALMETPEFSRHLAAVRMG

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 32974; Mature: 32974

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTDEARAKLAAIPMLAGYTGPLERLGGLTNLVFRAGDLCLRIPGKGTEEYINRANEAVA
CCCCHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
AREAAKAGVSPEVLHVDPATGVMVTRYIAGAQTMSPEKFKTRPGSPARAGEAFRKLHGSG
HHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCC
AVFPFRFELFAMIDDYLKVLSTKNVTLPAGYHDVVREAGGVRSALAAHPLPLAACHCDPL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCHHHHCCCHH
CENFLDTGERMWIVDWEYSGMNDPLWDLGDLSVEGKFNANQDEELMRAYFGGEARPAERG
HHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCC
RVVIYKAMCDLLWTLWGLIQLANDNPVDDFRAYADGRFARCKALMETPEFSRHLAAVRMG
CEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MMTDEARAKLAAIPMLAGYTGPLERLGGLTNLVFRAGDLCLRIPGKGTEEYINRANEAVA
CCCCHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
AREAAKAGVSPEVLHVDPATGVMVTRYIAGAQTMSPEKFKTRPGSPARAGEAFRKLHGSG
HHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCC
AVFPFRFELFAMIDDYLKVLSTKNVTLPAGYHDVVREAGGVRSALAAHPLPLAACHCDPL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCHHHHCCCHH
CENFLDTGERMWIVDWEYSGMNDPLWDLGDLSVEGKFNANQDEELMRAYFGGEARPAERG
HHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCC
RVVIYKAMCDLLWTLWGLIQLANDNPVDDFRAYADGRFARCKALMETPEFSRHLAAVRMG
CEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]