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The map label for this gene is hmrR [H]

Identifier: 13474432

GI number: 13474432

Start: 4240058

End: 4240516

Strand: Reverse

Name: hmrR [H]

Synonym: mll5312

Alternate gene names: 13474432

Gene position: 4240516-4240058 (Counterclockwise)

Preceding gene: 13474434

Following gene: 13474431

Centisome position: 60.27

GC content: 65.58

Gene sequence:

>459_bases
ATGAATGTCGGCGACGCCGCCCATCGTTCAGGCCTGCCGGCCAAGACCATCCGCTACTATGAGGAGATCGGCCTGATCGC
GCCGGCGCGCGCCGCCAACGGCTACCGTGATTATTCCGGTGACGACATCCATCGACTGACTTTCCTGCGCCGCGCGCGCA
ACCTCGGCTTTTCCATCGACGATTGCCGCCAGCTGATGGCGCTCTACCAAGATCGCGGCCGCGCCAGCGCCGACGTGCGA
GAGATCGCCGCCGCCCATGTCACGGCGATCGAGGAGAAGGTGCGCGAGCTGCAGTCGATGCGCGCGACACTGCAGAAGCT
GATCCACGCCTGCCATGGCGATGAGCGGCCGGACTGCCCGATCCTGGACGACATGGCAGGGGCCGCTGCGCCTGGCGACA
GGACCGTCTCAGCGAGACCATGGCCGACCTTAGCAATGGATTTTAGCCAGGCCGAGTGA

Upstream 100 bases:

>100_bases
GGTAAGCGTATCACTATGGCATTTCAGCAACAGCCTTCACCGGATTGTGAAGGAAATTCAATGGGCCGATCGCAGGCCCC
GCAAAATCGAGGACCACGCC

Downstream 100 bases:

>100_bases
GATGGCTTTCCGTGAGGCGCCGCATTGGGTGCCGTTATTCGCCCCGTGCCCGCCGGAACGGCGCGTCATTAAATTAGGCA
GTACTTATAGACCCATCGCC

Product: transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MNVGDAAHRSGLPAKTIRYYEEIGLIAPARAANGYRDYSGDDIHRLTFLRRARNLGFSIDDCRQLMALYQDRGRASADVR
EIAAAHVTAIEEKVRELQSMRATLQKLIHACHGDERPDCPILDDMAGAAAPGDRTVSARPWPTLAMDFSQAE

Sequences:

>Translated_152_residues
MNVGDAAHRSGLPAKTIRYYEEIGLIAPARAANGYRDYSGDDIHRLTFLRRARNLGFSIDDCRQLMALYQDRGRASADVR
EIAAAHVTAIEEKVRELQSMRATLQKLIHACHGDERPDCPILDDMAGAAAPGDRTVSARPWPTLAMDFSQAE
>Mature_152_residues
MNVGDAAHRSGLPAKTIRYYEEIGLIAPARAANGYRDYSGDDIHRLTFLRRARNLGFSIDDCRQLMALYQDRGRASADVR
EIAAAHVTAIEEKVRELQSMRATLQKLIHACHGDERPDCPILDDMAGAAAPGDRTVSARPWPTLAMDFSQAE

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=130, Percent_Identity=43.8461538461538, Blast_Score=119, Evalue=8e-29,
Organism=Escherichia coli, GI1789687, Length=132, Percent_Identity=32.5757575757576, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16824; Mature: 16824

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVGDAAHRSGLPAKTIRYYEEIGLIAPARAANGYRDYSGDDIHRLTFLRRARNLGFSID
CCCCCCHHHCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHH
DCRQLMALYQDRGRASADVREIAAAHVTAIEEKVRELQSMRATLQKLIHACHGDERPDCP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ILDDMAGAAAPGDRTVSARPWPTLAMDFSQAE
CHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MNVGDAAHRSGLPAKTIRYYEEIGLIAPARAANGYRDYSGDDIHRLTFLRRARNLGFSID
CCCCCCHHHCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHH
DCRQLMALYQDRGRASADVREIAAAHVTAIEEKVRELQSMRATLQKLIHACHGDERPDCP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ILDDMAGAAAPGDRTVSARPWPTLAMDFSQAE
CHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]