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The map label for this gene is tdh [H]

Identifier: 13474310

GI number: 13474310

Start: 4100905

End: 4101774

Strand: Reverse

Name: tdh [H]

Synonym: mll5168

Alternate gene names: 13474310

Gene position: 4101774-4100905 (Counterclockwise)

Preceding gene: 13474311

Following gene: 13474309

Centisome position: 58.3

GC content: 65.98

Gene sequence:

>870_bases
GTGACGCCCGGACATGAATTTTCGGGCATCGTCGAGGCAATCGGCAAGGCCGTCTCCGGCTTTGCCGTCGGCGATCGTGT
TACCGGGGATCCCAACATCGCCTGCGGACGGTGCCCGCATTGCCATGCCGGCCGGGTCAATCTCTGCCGCAATCTCAACG
CCATCGGCATCCATCGCGACGGCGGCTTTGCCGAGTATGTCGTGCTGCCGCAGAAACAGGCTTTCATCCTGCCGGCCGAT
CTGCCGCCGACGCATGGCGCCTTCTGCGAACCGCTCGGCTGCTGCCTGCATGGCGTGGACCTTGCGCAGATCAAGCCTGG
CAGTTCGGTGGTCGTGCTGGGCGGCGGCGTGATCGGCCTGCTGACGGTGCAACTGGCGAAACTGGCCGGAGCCACCACCA
TCATCCTGTCGACAAGGCAGGCTTCTCGGCGGGTGCTTGCCGAGGAACTCGGCGCGACAGCGACGGTCGATCCTACCGCC
GGCGATGTCATCGATGCCATCGCGGGATCCGAGGGCTTGATGCCCGGCGGCGCCGACGTGGTGTTCGAATGCGCTGGCGT
GCGCGACACCGTCGAACAATCGATGCGGCTGGCAAGGGCCGGCGGCACCGTCGTCATCGTCGGCGTGACGCCGCAAGGCA
TGAAGGCGGAATTCGAGCCCTTCGACCTGCTGTTTCGGGAATTGAAGGTGGTCGGCTCGTTCCTCAACCCCTACACGCAC
CGCCGCGCGGCCGAGCTCATCGCTTCGGGTGCGATCGAGATCGATCGGCTGATCTCCAGGCAGGTGCCGCTCGAAGAGGC
GGCCGATGTGATCGCCAATCCGCCAGCGCCCGGCGAGGTCAAGGTGCTGGTGGTGCCGCGACAGGGTTGA

Upstream 100 bases:

>100_bases
CTGCCCCCGGCCCGGACGAGCTTCTGGTACGGATCGAGGCCTGCGGCGTTTGCGGAACCGACCGGCATCTTTTCCATGGC
GAATTCCCTGCCGGCCGCCG

Downstream 100 bases:

>100_bases
GCCAAAGGCCAGTCGCGCCAGACCGGCTTGCCGTTACGCCGCCGATCGGTTATCGAGCCAGCGCCGAAAAAGACATGACC
GGTTCGGTAGTCCGGTCTCT

Product: 2,3-butanediol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTPGHEFSGIVEAIGKAVSGFAVGDRVTGDPNIACGRCPHCHAGRVNLCRNLNAIGIHRDGGFAEYVVLPQKQAFILPAD
LPPTHGAFCEPLGCCLHGVDLAQIKPGSSVVVLGGGVIGLLTVQLAKLAGATTIILSTRQASRRVLAEELGATATVDPTA
GDVIDAIAGSEGLMPGGADVVFECAGVRDTVEQSMRLARAGGTVVIVGVTPQGMKAEFEPFDLLFRELKVVGSFLNPYTH
RRAAELIASGAIEIDRLISRQVPLEEAADVIANPPAPGEVKVLVVPRQG

Sequences:

>Translated_289_residues
MTPGHEFSGIVEAIGKAVSGFAVGDRVTGDPNIACGRCPHCHAGRVNLCRNLNAIGIHRDGGFAEYVVLPQKQAFILPAD
LPPTHGAFCEPLGCCLHGVDLAQIKPGSSVVVLGGGVIGLLTVQLAKLAGATTIILSTRQASRRVLAEELGATATVDPTA
GDVIDAIAGSEGLMPGGADVVFECAGVRDTVEQSMRLARAGGTVVIVGVTPQGMKAEFEPFDLLFRELKVVGSFLNPYTH
RRAAELIASGAIEIDRLISRQVPLEEAADVIANPPAPGEVKVLVVPRQG
>Mature_288_residues
TPGHEFSGIVEAIGKAVSGFAVGDRVTGDPNIACGRCPHCHAGRVNLCRNLNAIGIHRDGGFAEYVVLPQKQAFILPADL
PPTHGAFCEPLGCCLHGVDLAQIKPGSSVVVLGGGVIGLLTVQLAKLAGATTIILSTRQASRRVLAEELGATATVDPTAG
DVIDAIAGSEGLMPGGADVVFECAGVRDTVEQSMRLARAGGTVVIVGVTPQGMKAEFEPFDLLFRELKVVGSFLNPYTHR
RAAELIASGAIEIDRLISRQVPLEEAADVIANPPAPGEVKVLVVPRQG

Specific function: Converts Galactitol 1-Phosphate To Tagatose 6-Phosphate. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=273, Percent_Identity=27.8388278388278, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4501933, Length=294, Percent_Identity=28.9115646258503, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501929, Length=294, Percent_Identity=28.9115646258503, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34577061, Length=294, Percent_Identity=29.2517006802721, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI71743840, Length=298, Percent_Identity=26.510067114094, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI262073058, Length=298, Percent_Identity=26.510067114094, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI156523966, Length=300, Percent_Identity=26.3333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4501939, Length=300, Percent_Identity=26.3333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI71565154, Length=234, Percent_Identity=27.3504273504274, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788407, Length=302, Percent_Identity=32.7814569536424, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788073, Length=259, Percent_Identity=32.8185328185328, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790045, Length=268, Percent_Identity=31.7164179104478, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI226510992, Length=279, Percent_Identity=34.4086021505376, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787863, Length=270, Percent_Identity=28.1481481481481, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1788075, Length=283, Percent_Identity=30.0353356890459, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790718, Length=291, Percent_Identity=30.2405498281787, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082125, Length=283, Percent_Identity=30.3886925795053, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786825, Length=316, Percent_Identity=30.0632911392405, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786552, Length=284, Percent_Identity=28.5211267605634, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081918, Length=234, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=289, Percent_Identity=31.4878892733564, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562878, Length=292, Percent_Identity=31.5068493150685, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71997431, Length=304, Percent_Identity=27.3026315789474, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=296, Percent_Identity=27.027027027027, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=304, Percent_Identity=27.3026315789474, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=238, Percent_Identity=31.0924369747899, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=257, Percent_Identity=27.2373540856031, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=281, Percent_Identity=26.3345195729537, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=277, Percent_Identity=32.8519855595668, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319257, Length=289, Percent_Identity=31.8339100346021, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=277, Percent_Identity=32.4909747292419, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=275, Percent_Identity=32.3636363636364, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=246, Percent_Identity=32.1138211382114, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=296, Percent_Identity=26.0135135135135, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=258, Percent_Identity=30.2325581395349, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=256, Percent_Identity=27.734375, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=256, Percent_Identity=27.734375, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=255, Percent_Identity=25.0980392156863, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17137530, Length=293, Percent_Identity=31.0580204778157, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17737897, Length=291, Percent_Identity=30.9278350515464, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45550770, Length=271, Percent_Identity=26.9372693726937, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45551930, Length=271, Percent_Identity=26.9372693726937, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221457811, Length=271, Percent_Identity=26.9372693726937, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17737895, Length=304, Percent_Identity=27.3026315789474, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 29991; Mature: 29860

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGHEFSGIVEAIGKAVSGFAVGDRVTGDPNIACGRCPHCHAGRVNLCRNLNAIGIHRD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEECC
GGFAEYVVLPQKQAFILPADLPPTHGAFCEPLGCCLHGVDLAQIKPGSSVVVLGGGVIGL
CCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEECCCCEEEEECCCHHHH
LTVQLAKLAGATTIILSTRQASRRVLAEELGATATVDPTAGDVIDAIAGSEGLMPGGADV
HHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCCCCCCCCCE
VFECAGVRDTVEQSMRLARAGGTVVIVGVTPQGMKAEFEPFDLLFRELKVVGSFLNPYTH
EEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCHHHH
RRAAELIASGAIEIDRLISRQVPLEEAADVIANPPAPGEVKVLVVPRQG
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TPGHEFSGIVEAIGKAVSGFAVGDRVTGDPNIACGRCPHCHAGRVNLCRNLNAIGIHRD
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEECC
GGFAEYVVLPQKQAFILPADLPPTHGAFCEPLGCCLHGVDLAQIKPGSSVVVLGGGVIGL
CCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEECCCCEEEEECCCHHHH
LTVQLAKLAGATTIILSTRQASRRVLAEELGATATVDPTAGDVIDAIAGSEGLMPGGADV
HHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCCCCCCCCCE
VFECAGVRDTVEQSMRLARAGGTVVIVGVTPQGMKAEFEPFDLLFRELKVVGSFLNPYTH
EEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCHHHH
RRAAELIASGAIEIDRLISRQVPLEEAADVIANPPAPGEVKVLVVPRQG
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA