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The map label for this gene is trxA [C]

Identifier: 13474238

GI number: 13474238

Start: 4021022

End: 4021345

Strand: Reverse

Name: trxA [C]

Synonym: mll5082

Alternate gene names: 13474238

Gene position: 4021345-4021022 (Counterclockwise)

Preceding gene: 13474239

Following gene: 13474237

Centisome position: 57.15

GC content: 60.49

Gene sequence:

>324_bases
ATGGGTGCCACCGTCAAGGTCGACAAGAACAATTTCCAGGCTGACGTGCTCAACGCCAACGTACCGGTGGTGGTCGATTT
CTGGGCGGAATGGTGCGGCCCCTGCAAGCAGATCGCGCCGTCGCTCGAAGACATCGCCACTGAACTCGGAGCCAAGATCA
AGATCGCCAAACTCAACATCGATGAGAACCCCGAGCTTGCCGCGCAGTTCGGCGTGCGCTCGATCCCAACGCTGATGATC
TTCAAGGGCGGCGAAGTGGCCGACATGAAGGTTGGCGCCGCGCCGAAGACCGCGCTGTCGCACTGGATCAATGGCAGCCT
CTGA

Upstream 100 bases:

>100_bases
TTGCCCGACTCACGGGAGCGTGACACAAGACCTGCTTGAAGAAGGGCTAGATAACCACCACATTTGGTGCGACAAAGAAC
TCTCGAAAGGAATTTTCCGC

Downstream 100 bases:

>100_bases
TCCTCTCTGTTTAGACGCAATTCCGGACAGAAAACCGCTTCACACTTTTCTTGGAATGCTTTGAAATTCCCGATAGCAAG
AGCCCGGCCATCGCGCCGGG

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MGATVKVDKNNFQADVLNANVPVVVDFWAEWCGPCKQIAPSLEDIATELGAKIKIAKLNIDENPELAAQFGVRSIPTLMI
FKGGEVADMKVGAAPKTALSHWINGSL

Sequences:

>Translated_107_residues
MGATVKVDKNNFQADVLNANVPVVVDFWAEWCGPCKQIAPSLEDIATELGAKIKIAKLNIDENPELAAQFGVRSIPTLMI
FKGGEVADMKVGAAPKTALSHWINGSL
>Mature_106_residues
GATVKVDKNNFQADVLNANVPVVVDFWAEWCGPCKQIAPSLEDIATELGAKIKIAKLNIDENPELAAQFGVRSIPTLMIF
KGGEVADMKVGAAPKTALSHWINGSL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=39.1752577319588, Blast_Score=85, Evalue=1e-17,
Organism=Homo sapiens, GI20070125, Length=100, Percent_Identity=38, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI21361657, Length=96, Percent_Identity=34.375, Blast_Score=63, Evalue=5e-11,
Organism=Homo sapiens, GI4758304, Length=88, Percent_Identity=38.6363636363636, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=51.4563106796116, Blast_Score=118, Evalue=9e-29,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=51.0869565217391, Blast_Score=112, Evalue=5e-27,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=34.2857142857143, Blast_Score=69, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=76, Percent_Identity=42.1052631578947, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115532378, Length=74, Percent_Identity=40.5405405405405, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=40.5405405405405, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=80, Percent_Identity=41.25, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=74, Percent_Identity=40.5405405405405, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=80, Percent_Identity=41.25, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=87, Percent_Identity=39.0804597701149, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=80, Percent_Identity=41.25, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=75, Percent_Identity=36, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=73, Percent_Identity=47.945205479452, Blast_Score=69, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=45.2054794520548, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28573567, Length=99, Percent_Identity=37.3737373737374, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=41.25, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24664269, Length=64, Percent_Identity=43.75, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358065, Length=94, Percent_Identity=37.2340425531915, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=37.6623376623377, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=36.4864864864865, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=36.4864864864865, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639068, Length=97, Percent_Identity=30.9278350515464, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24658597, Length=94, Percent_Identity=38.2978723404255, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11449; Mature: 11318

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGATVKVDKNNFQADVLNANVPVVVDFWAEWCGPCKQIAPSLEDIATELGAKIKIAKLNI
CCCEEEECCCCCEEEEECCCCCEEEEEHHHHCCHHHHHCCCHHHHHHHCCCEEEEEEECC
DENPELAAQFGVRSIPTLMIFKGGEVADMKVGAAPKTALSHWINGSL
CCCCHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHCCCCC
>Mature Secondary Structure 
GATVKVDKNNFQADVLNANVPVVVDFWAEWCGPCKQIAPSLEDIATELGAKIKIAKLNI
CCEEEECCCCCEEEEECCCCCEEEEEHHHHCCHHHHHCCCHHHHHHHCCCEEEEEEECC
DENPELAAQFGVRSIPTLMIFKGGEVADMKVGAAPKTALSHWINGSL
CCCCHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]