Click here to switch to the map view.

The map label for this gene is cbs [H]

Identifier: 13473791

GI number: 13473791

Start: 3583138

End: 3584577

Strand: Reverse

Name: cbs [H]

Synonym: mll4505

Alternate gene names: 13473791

Gene position: 3584577-3583138 (Counterclockwise)

Preceding gene: 13473792

Following gene: 13473790

Centisome position: 50.95

GC content: 64.03

Gene sequence:

>1440_bases
ATGAGCGAGCACGGAAAAGCTGCGCCAGGCAGCGCCCCCTCGGATGGCCAATCTGCGCGCCTGCGGCCACCTTATAAATC
GGTTCTCGACCTGATCGGCCAGACGCCGGTGGTCGAGCTGACCAAGTTCGACACCGGCAAATGCCGGCTGTTCATCAAGC
TCGAAAGCCAGAACCCGGGCGGCTCGATCAAGGACCGCATCGCGCTGTCGATGATCGCGGCGGCCGAGAGAGAGGGCAAG
CTCAAGCGCGGCGGCACCATCGTCGAGGCGACCGCCGGCAATACCGGCCTCGGCCTTGCCCAGGTCGGCATCCCCAAGGG
CTACCGCATCGTGCTGGTGGTGCCCGACAAGATGTCGCGCGAGAAGATCCAGCATCTGCGCGCGCTGGGCGCCGAGGTGC
GCATGACGCGCTCCGATGTCGGCAAGGGCCACCCGGAATATTACCAGGACATGGCCGAGAAGATCGCCGCCGAAGTGCCC
GGCGCCTTCTATGCCAACCAGTTCGCCAATCCGGCCAACCCGCTGGCGCATGAGACGACGACCGGCCCGGAAATCTTTTC
GCAGCTCGACGGCAATGTCGACGCGGTGGTCGTCGGCGTCGGCTCGGGCGGCACGCTGACCGGGCTTGGCCGCTATTTTT
CGAAAGTCTCGCCCAAGACCGAAATGGTGCTGGCCGATCCGGTCGGCTCGGTGCTGGCGCCGCTGATCAAGACCGGCAAG
ATGGAAGAGGCCGGCAGCTGGACGGTGGAAGGCATCGGCGAGGATTTCGTGCCGCCCAATGCCGATCTGTCGCTGGTCAA
GAAGGCCTATTCGATATCAGACAAGCAAAGCATGCTGGCGGTGCGTGATCTGCTGTCACGCGAAGGCATTCTGGCTGGTT
CGTCCTCGGGCACGCTTTTATCGGCCGCCTTGCGCTATTGCCGCGAGCAGACGACGCCGAAGCGCGTCGTCACCTTCGTC
TGCGACAGCGGCAACAAGTACCTGTCCAAGGTCTTCGACGATTTCTGGCTGGCCGAACAGGGCCTGGCCGAACACGAGCA
GCATGGCGATCTGCGCGACCTCGTGATGCGCTCGCACCGCACCGGCGACACGGTCTATGTCGGCCCCGACGAAAGCCTGC
TCAACGCCTACGGCCGCATGCGCCGTTCCGATGTCTCGCAGCTGCCGGTTCTGGAAGATGGCAAGCTGATCGGCATCGTC
GACGAGAGCGATATTCTGGCCAAGGTCGACGGACCCTATGACGGCCGCTGGGAGCGCTTCAACGGTCCGGTGCGCACGGC
GATGACCTCCAATCTGCACACGCTGCAGGCCAGCCAGACGCTGGATGCACTGTTGCCGGTGTTCGACCGCAACGAGGTCG
CCATCATCTTCGACGGCGACGAGTTCGTCGGCCTGATCACCCGGATCGACCTGATCAACCATTTGAGGCGCGCACGATGA

Upstream 100 bases:

>100_bases
GCCGGCTCAATCAAATAAGTAGAGCATGATGTCGTCCGAAAACCGCTTCACACTTTTCGGCATCATGCTCTAGGCGGTCG
CTTGATCAGGGAGCTTCGAT

Downstream 100 bases:

>100_bases
CCAGCCACACACCACCACCATCGGGCAAGAATCGCCTGGCCTTCTCGACACGCACCATCCATGGCGGCCAGAGCCACGAT
CCGCTGACCGGCGCGGTGAT

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSEHGKAAPGSAPSDGQSARLRPPYKSVLDLIGQTPVVELTKFDTGKCRLFIKLESQNPGGSIKDRIALSMIAAAEREGK
LKRGGTIVEATAGNTGLGLAQVGIPKGYRIVLVVPDKMSREKIQHLRALGAEVRMTRSDVGKGHPEYYQDMAEKIAAEVP
GAFYANQFANPANPLAHETTTGPEIFSQLDGNVDAVVVGVGSGGTLTGLGRYFSKVSPKTEMVLADPVGSVLAPLIKTGK
MEEAGSWTVEGIGEDFVPPNADLSLVKKAYSISDKQSMLAVRDLLSREGILAGSSSGTLLSAALRYCREQTTPKRVVTFV
CDSGNKYLSKVFDDFWLAEQGLAEHEQHGDLRDLVMRSHRTGDTVYVGPDESLLNAYGRMRRSDVSQLPVLEDGKLIGIV
DESDILAKVDGPYDGRWERFNGPVRTAMTSNLHTLQASQTLDALLPVFDRNEVAIIFDGDEFVGLITRIDLINHLRRAR

Sequences:

>Translated_479_residues
MSEHGKAAPGSAPSDGQSARLRPPYKSVLDLIGQTPVVELTKFDTGKCRLFIKLESQNPGGSIKDRIALSMIAAAEREGK
LKRGGTIVEATAGNTGLGLAQVGIPKGYRIVLVVPDKMSREKIQHLRALGAEVRMTRSDVGKGHPEYYQDMAEKIAAEVP
GAFYANQFANPANPLAHETTTGPEIFSQLDGNVDAVVVGVGSGGTLTGLGRYFSKVSPKTEMVLADPVGSVLAPLIKTGK
MEEAGSWTVEGIGEDFVPPNADLSLVKKAYSISDKQSMLAVRDLLSREGILAGSSSGTLLSAALRYCREQTTPKRVVTFV
CDSGNKYLSKVFDDFWLAEQGLAEHEQHGDLRDLVMRSHRTGDTVYVGPDESLLNAYGRMRRSDVSQLPVLEDGKLIGIV
DESDILAKVDGPYDGRWERFNGPVRTAMTSNLHTLQASQTLDALLPVFDRNEVAIIFDGDEFVGLITRIDLINHLRRAR
>Mature_478_residues
SEHGKAAPGSAPSDGQSARLRPPYKSVLDLIGQTPVVELTKFDTGKCRLFIKLESQNPGGSIKDRIALSMIAAAEREGKL
KRGGTIVEATAGNTGLGLAQVGIPKGYRIVLVVPDKMSREKIQHLRALGAEVRMTRSDVGKGHPEYYQDMAEKIAAEVPG
AFYANQFANPANPLAHETTTGPEIFSQLDGNVDAVVVGVGSGGTLTGLGRYFSKVSPKTEMVLADPVGSVLAPLIKTGKM
EEAGSWTVEGIGEDFVPPNADLSLVKKAYSISDKQSMLAVRDLLSREGILAGSSSGTLLSAALRYCREQTTPKRVVTFVC
DSGNKYLSKVFDDFWLAEQGLAEHEQHGDLRDLVMRSHRTGDTVYVGPDESLLNAYGRMRRSDVSQLPVLEDGKLIGIVD
ESDILAKVDGPYDGRWERFNGPVRTAMTSNLHTLQASQTLDALLPVFDRNEVAIIFDGDEFVGLITRIDLINHLRRAR

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=416, Percent_Identity=35.3365384615385, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI295821200, Length=416, Percent_Identity=35.3365384615385, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI4557415, Length=416, Percent_Identity=35.3365384615385, Blast_Score=249, Evalue=5e-66,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=40.7766990291262, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=38.3333333333333, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=41.5841584158416, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=41.1184210526316, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25147552, Length=323, Percent_Identity=37.7708978328173, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=340, Percent_Identity=38.5294117647059, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=38.2352941176471, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI115535073, Length=333, Percent_Identity=37.8378378378378, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17561720, Length=314, Percent_Identity=38.5350318471338, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=218, Percent_Identity=39.4495412844037, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71996324, Length=356, Percent_Identity=29.2134831460674, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17539800, Length=344, Percent_Identity=24.7093023255814, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539640, Length=355, Percent_Identity=27.0422535211268, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=495, Percent_Identity=35.1515151515151, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6321449, Length=336, Percent_Identity=34.2261904761905, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24643623, Length=462, Percent_Identity=32.6839826839827, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI20129101, Length=462, Percent_Identity=32.6839826839827, Blast_Score=224, Evalue=8e-59,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 51864; Mature: 51732

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHGKAAPGSAPSDGQSARLRPPYKSVLDLIGQTPVVELTKFDTGKCRLFIKLESQNPG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEEEEECCCCC
GSIKDRIALSMIAAAEREGKLKRGGTIVEATAGNTGLGLAQVGIPKGYRIVLVVPDKMSR
CCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEECCCCCCH
EKIQHLRALGAEVRMTRSDVGKGHPEYYQDMAEKIAAEVPGAFYANQFANPANPLAHETT
HHHHHHHHHCHHHEECHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
TGPEIFSQLDGNVDAVVVGVGSGGTLTGLGRYFSKVSPKTEMVLADPVGSVLAPLIKTGK
CCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCC
MEEAGSWTVEGIGEDFVPPNADLSLVKKAYSISDKQSMLAVRDLLSREGILAGSSSGTLL
CCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECCCCCHHH
SAALRYCREQTTPKRVVTFVCDSGNKYLSKVFDDFWLAEQGLAEHEQHGDLRDLVMRSHR
HHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
TGDTVYVGPDESLLNAYGRMRRSDVSQLPVLEDGKLIGIVDESDILAKVDGPYDGRWERF
CCCEEEECCCHHHHHHHHHHHHCCHHHCCEECCCCEEEEECCCCEEEEECCCCCCCCHHC
NGPVRTAMTSNLHTLQASQTLDALLPVFDRNEVAIIFDGDEFVGLITRIDLINHLRRAR
CCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEHGKAAPGSAPSDGQSARLRPPYKSVLDLIGQTPVVELTKFDTGKCRLFIKLESQNPG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEEEEECCCCC
GSIKDRIALSMIAAAEREGKLKRGGTIVEATAGNTGLGLAQVGIPKGYRIVLVVPDKMSR
CCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEECCCCCCH
EKIQHLRALGAEVRMTRSDVGKGHPEYYQDMAEKIAAEVPGAFYANQFANPANPLAHETT
HHHHHHHHHCHHHEECHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
TGPEIFSQLDGNVDAVVVGVGSGGTLTGLGRYFSKVSPKTEMVLADPVGSVLAPLIKTGK
CCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCC
MEEAGSWTVEGIGEDFVPPNADLSLVKKAYSISDKQSMLAVRDLLSREGILAGSSSGTLL
CCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECCCCCHHH
SAALRYCREQTTPKRVVTFVCDSGNKYLSKVFDDFWLAEQGLAEHEQHGDLRDLVMRSHR
HHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
TGDTVYVGPDESLLNAYGRMRRSDVSQLPVLEDGKLIGIVDESDILAKVDGPYDGRWERF
CCCEEEECCCHHHHHHHHHHHHCCHHHCCEECCCCEEEEECCCCEEEEECCCCCCCCHHC
NGPVRTAMTSNLHTLQASQTLDALLPVFDRNEVAIIFDGDEFVGLITRIDLINHLRRAR
CCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]