Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 13473735

GI number: 13473735

Start: 3513071

End: 3514078

Strand: Reverse

Name: trxA [H]

Synonym: mll4432

Alternate gene names: 13473735

Gene position: 3514078-3513071 (Counterclockwise)

Preceding gene: 13473736

Following gene: 13473734

Centisome position: 49.94

GC content: 67.36

Gene sequence:

>1008_bases
ATGAGCGACAACAAGCCGTTTGGCGGGTCATTCGGCAGCAATGGCGGCCAATATGCGACCACCGTTCAGTATGGCGGAAC
CGCAGCCGCGCCTGCGAAGGTCTCGCTTGGAGATACGCCGGCCGCCGCCCCCGCGGGCGATGTCATCAAGGACACCACGA
CCGCCGCCTTTGCCGCCGACGTCATCCAGGAATCGCGCCGCCAGCCGGTGCTGGTCGATTTCTGGGCGCCGTGGTGCGGC
CCTTGCAAGCAGCTGACGCCGCAGCTGGAAAAGGCGGTCCGGGCCGCCGGCGGCAAGGTCAAGCTGGTCAAGATGAACAT
CGACGACCATCCCTCGATCGCCGGCCAGCTCGGCATCCAGTCGATTCCGGCGGTCATCGCCTTCAAGGACGGCCAGCCGG
TCGACGGCTTCATGGGTGCCATCCCGGAGAGCCAGATCGCCGAGTTCATCACCAAGGTCGGCGGCAAGGGCAATGGTGCT
CCGGCCGTGGCCGAGGCGCTGGCGGCTGCGACCGAAGCGCGCGAGGCCGGCGACATGCAGACCGCCGCCGACATTTTTGA
CGCCATCCTGGCGCAGGCACCGGAGACGATCGAGGCGATCGCCGGGCTGGGCGAGCTGCTGTTCGAGGCCGGCGACACGG
AAGGCGCCGAGGCGTTGCTGGCAACGGCGCCCGAGGCCAAGAAGGACGCGCCTGTTCTGGCCGCCTTGCGCGCCAAGATG
GCGCTGGCCGCGCAAGCGGCGGAACTGGGCAATCCCGCAGAGTTCGAGCGCCGCCTGGCCGAAAACCCCAAAGACCATCA
GGCGCGTTTCGATCTGGCCATGATCCAGAACGCCAGGGGCGAACGCACGGCGGCCGCCGATAATCTGCTGGCCATCATCA
AGGCCGATCGCGGCTGGAACGAGGATGGCGCCAGGACGCAATTGCTGCAGTTTTTCGAGGCCTGGGGCATGACCGACGAG
GCGACGCTGGCCGCGCGGCGCAAATTGTCGGCGCTGCTGTTTTCCTGA

Upstream 100 bases:

>100_bases
CTTGAAAGTCTCGGCATGATCGCCACATGCATGGCGAAACCGACTTCCAATGACATGGCGCCGACCCGCGGGCCGGCGGC
GCGACCGAAAGGGTGACGAG

Downstream 100 bases:

>100_bases
GCAGGCGGCTGTTTCGTCGCACGGGCTTGTGGCCGGCGGCGGCCGCGCCAGATTAGGTAGCTGACTTCGGCCAAGCCGAC
GATCCCGGCGGCGGGCGACG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSDNKPFGGSFGSNGGQYATTVQYGGTAAAPAKVSLGDTPAAAPAGDVIKDTTTAAFAADVIQESRRQPVLVDFWAPWCG
PCKQLTPQLEKAVRAAGGKVKLVKMNIDDHPSIAGQLGIQSIPAVIAFKDGQPVDGFMGAIPESQIAEFITKVGGKGNGA
PAVAEALAAATEAREAGDMQTAADIFDAILAQAPETIEAIAGLGELLFEAGDTEGAEALLATAPEAKKDAPVLAALRAKM
ALAAQAAELGNPAEFERRLAENPKDHQARFDLAMIQNARGERTAAADNLLAIIKADRGWNEDGARTQLLQFFEAWGMTDE
ATLAARRKLSALLFS

Sequences:

>Translated_335_residues
MSDNKPFGGSFGSNGGQYATTVQYGGTAAAPAKVSLGDTPAAAPAGDVIKDTTTAAFAADVIQESRRQPVLVDFWAPWCG
PCKQLTPQLEKAVRAAGGKVKLVKMNIDDHPSIAGQLGIQSIPAVIAFKDGQPVDGFMGAIPESQIAEFITKVGGKGNGA
PAVAEALAAATEAREAGDMQTAADIFDAILAQAPETIEAIAGLGELLFEAGDTEGAEALLATAPEAKKDAPVLAALRAKM
ALAAQAAELGNPAEFERRLAENPKDHQARFDLAMIQNARGERTAAADNLLAIIKADRGWNEDGARTQLLQFFEAWGMTDE
ATLAARRKLSALLFS
>Mature_334_residues
SDNKPFGGSFGSNGGQYATTVQYGGTAAAPAKVSLGDTPAAAPAGDVIKDTTTAAFAADVIQESRRQPVLVDFWAPWCGP
CKQLTPQLEKAVRAAGGKVKLVKMNIDDHPSIAGQLGIQSIPAVIAFKDGQPVDGFMGAIPESQIAEFITKVGGKGNGAP
AVAEALAAATEAREAGDMQTAADIFDAILAQAPETIEAIAGLGELLFEAGDTEGAEALLATAPEAKKDAPVLAALRAKMA
LAAQAAELGNPAEFERRLAENPKDHQARFDLAMIQNARGERTAAADNLLAIIKADRGWNEDGARTQLLQFFEAWGMTDEA
TLAARRKLSALLFS

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG3118

COG function: function code O; Thioredoxin domain-containing protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=87, Percent_Identity=47.1264367816092, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI87081747, Length=274, Percent_Identity=29.9270072992701, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=40.4761904761905, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=38.4615384615385, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=44.3298969072165, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=73, Percent_Identity=38.3561643835616, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=36, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358065, Length=110, Percent_Identity=32.7272727272727, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 34856; Mature: 34724

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50293 TPR_REGION ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNKPFGGSFGSNGGQYATTVQYGGTAAAPAKVSLGDTPAAAPAGDVIKDTTTAAFAAD
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
VIQESRRQPVLVDFWAPWCGPCKQLTPQLEKAVRAAGGKVKLVKMNIDDHPSIAGQLGIQ
HHHHHCCCCEEEEECCCCCCCHHHHCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHCHH
SIPAVIAFKDGQPVDGFMGAIPESQIAEFITKVGGKGNGAPAVAEALAAATEAREAGDMQ
HCCEEEEECCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
TAADIFDAILAQAPETIEAIAGLGELLFEAGDTEGAEALLATAPEAKKDAPVLAALRAKM
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHH
ALAAQAAELGNPAEFERRLAENPKDHQARFDLAMIQNARGERTAAADNLLAIIKADRGWN
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHEEEEEECCCCCC
EDGARTQLLQFFEAWGMTDEATLAARRKLSALLFS
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDNKPFGGSFGSNGGQYATTVQYGGTAAAPAKVSLGDTPAAAPAGDVIKDTTTAAFAAD
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
VIQESRRQPVLVDFWAPWCGPCKQLTPQLEKAVRAAGGKVKLVKMNIDDHPSIAGQLGIQ
HHHHHCCCCEEEEECCCCCCCHHHHCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHCHH
SIPAVIAFKDGQPVDGFMGAIPESQIAEFITKVGGKGNGAPAVAEALAAATEAREAGDMQ
HCCEEEEECCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
TAADIFDAILAQAPETIEAIAGLGELLFEAGDTEGAEALLATAPEAKKDAPVLAALRAKM
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHH
ALAAQAAELGNPAEFERRLAENPKDHQARFDLAMIQNARGERTAAADNLLAIIKADRGWN
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHEEEEEECCCCCC
EDGARTQLLQFFEAWGMTDEATLAARRKLSALLFS
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]