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The map label for this gene is sucD [H]

Identifier: 13473638

GI number: 13473638

Start: 3427332

End: 3428234

Strand: Reverse

Name: sucD [H]

Synonym: mll4303

Alternate gene names: 13473638

Gene position: 3428234-3427332 (Counterclockwise)

Preceding gene: 13473639

Following gene: 13473637

Centisome position: 48.72

GC content: 65.01

Gene sequence:

>903_bases
ATGTCCATTCTCGTCGACAAGAACACCAAGGTGCTGGTGCAGGGCCTGACCGGCAAGACCGGTACGTTCCACACCGAACA
GGCGCTGGCCTATCACGGCACCAAGATGGTGGGTGGCATCCATCCCAAGAAGGGCGGCGAGACGTGGACCGGCTCGAAGG
GCGAGAGCCTGCCGATCTTCGCCACCGTCGCCGAAGGTAAGGCAAAGACCGGGGCCAACGCCTCCGTCGTTTACGTGCCG
CCGGCAGGTGCCGCCGAAGCGATCCTGGAAGCGATCGAGGCCGAGATCCCGCTGATCATCTGCATCACCGAAGGCATTCC
GGTGATGGACATGGTCAAGGTCAAGGCGCGGCTCGACCGCTCGACCTCGCGGCTGATCGGCCCGAACTGCCCGGGCGTTC
TCACCCCCGACGAATGCAAGATCGGCATCATGCCTGGAAACATCTTCCGCAAGGGCTCGGTCGGCGTTGTTTCGCGCTCG
GGAACACTTACCTATGAGGCCGTGTTCCAAACCACCAATGTCGGCCTCGGCCAGACCACCGCCGTCGGCATCGGTGGCGA
CCCGGTCAAGGGCACCGAGTTCATCGACGTGCTCGAGATGTTCCTGGCCGACGATGAGACCAAGTCGATCATCATGATCG
GCGAGATCGGCGGTTCGGCCGAGGAAGACGCCGCGCAGTTCCTCAAGGACGAAGCCAAGCGTGGCCGCAAGAAGCCGATG
GCCGGCTTCATCGCCGGGCGCACGGCGCCGGCCGGCCGCACGATGGGCCATGCCGGCGCGGTCATCTCCGGCGGCAAAGG
CGGCGCCGAGGACAAGATCGCGGCGATGGAATCGGCCGGCATCAAGGTCTCGCCGTCACCGGCGCGGCTGGGAACGACGC
TGGTCGAGGCGATCAAGGGATAA

Upstream 100 bases:

>100_bases
TTTCAAACCCGCCGGCAGCGATGGCTGGCAAGACATGGTGAGTGGCGTCTACCGGCGCGTCTCGCCTTCCTCGATCAACA
GTTTTTAGAAAAGGGCTCCG

Downstream 100 bases:

>100_bases
GAACGCGAGCAGTCGAGCTTTCGAATGCCGATGAGCAGGACATGGAAGACGAGAAGCGCATCATTCTATGCATACCAGGC
CTTTGGGAAGGCAGGTCGGC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSILVDKNTKVLVQGLTGKTGTFHTEQALAYHGTKMVGGIHPKKGGETWTGSKGESLPIFATVAEGKAKTGANASVVYVP
PAGAAEAILEAIEAEIPLIICITEGIPVMDMVKVKARLDRSTSRLIGPNCPGVLTPDECKIGIMPGNIFRKGSVGVVSRS
GTLTYEAVFQTTNVGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIIMIGEIGGSAEEDAAQFLKDEAKRGRKKPM
AGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPARLGTTLVEAIKG

Sequences:

>Translated_300_residues
MSILVDKNTKVLVQGLTGKTGTFHTEQALAYHGTKMVGGIHPKKGGETWTGSKGESLPIFATVAEGKAKTGANASVVYVP
PAGAAEAILEAIEAEIPLIICITEGIPVMDMVKVKARLDRSTSRLIGPNCPGVLTPDECKIGIMPGNIFRKGSVGVVSRS
GTLTYEAVFQTTNVGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIIMIGEIGGSAEEDAAQFLKDEAKRGRKKPM
AGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPARLGTTLVEAIKG
>Mature_299_residues
SILVDKNTKVLVQGLTGKTGTFHTEQALAYHGTKMVGGIHPKKGGETWTGSKGESLPIFATVAEGKAKTGANASVVYVPP
AGAAEAILEAIEAEIPLIICITEGIPVMDMVKVKARLDRSTSRLIGPNCPGVLTPDECKIGIMPGNIFRKGSVGVVSRSG
TLTYEAVFQTTNVGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIIMIGEIGGSAEEDAAQFLKDEAKRGRKKPMA
GFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPARLGTTLVEAIKG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=298, Percent_Identity=64.4295302013423, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI38569423, Length=307, Percent_Identity=27.0358306188925, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI38569421, Length=307, Percent_Identity=27.0358306188925, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786949, Length=299, Percent_Identity=60.8695652173913, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17550194, Length=300, Percent_Identity=59.3333333333333, Blast_Score=342, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17553126, Length=300, Percent_Identity=59.3333333333333, Blast_Score=339, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17557344, Length=312, Percent_Identity=28.2051282051282, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17551266, Length=314, Percent_Identity=28.9808917197452, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324716, Length=300, Percent_Identity=50, Blast_Score=278, Evalue=5e-76,
Organism=Drosophila melanogaster, GI21356559, Length=298, Percent_Identity=58.0536912751678, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI28574296, Length=299, Percent_Identity=62.2073578595318, Blast_Score=328, Evalue=2e-90,
Organism=Drosophila melanogaster, GI281363477, Length=282, Percent_Identity=29.4326241134752, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363475, Length=282, Percent_Identity=29.4326241134752, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363473, Length=282, Percent_Identity=29.4326241134752, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30862; Mature: 30731

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVDKNTKVLVQGLTGKTGTFHTEQALAYHGTKMVGGIHPKKGGETWTGSKGESLPIF
CEEEEECCCEEEEEECCCCCCCEECHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCEEE
ATVAEGKAKTGANASVVYVPPAGAAEAILEAIEAEIPLIICITEGIPVMDMVKVKARLDR
EEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCC
STSRLIGPNCPGVLTPDECKIGIMPGNIFRKGSVGVVSRSGTLTYEAVFQTTNVGLGQTT
CHHHHCCCCCCCCCCCCCCEEEEECCCEEECCCCEEEECCCCEEEEEEEEECCCCCCCEE
AVGIGGDPVKGTEFIDVLEMFLADDETKSIIMIGEIGGSAEEDAAQFLKDEAKRGRKKPM
EEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
AGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPARLGTTLVEAIKG
EEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SILVDKNTKVLVQGLTGKTGTFHTEQALAYHGTKMVGGIHPKKGGETWTGSKGESLPIF
EEEEECCCEEEEEECCCCCCCEECHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCEEE
ATVAEGKAKTGANASVVYVPPAGAAEAILEAIEAEIPLIICITEGIPVMDMVKVKARLDR
EEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCC
STSRLIGPNCPGVLTPDECKIGIMPGNIFRKGSVGVVSRSGTLTYEAVFQTTNVGLGQTT
CHHHHCCCCCCCCCCCCCCEEEEECCCEEECCCCEEEECCCCEEEEEEEEECCCCCCCEE
AVGIGGDPVKGTEFIDVLEMFLADDETKSIIMIGEIGGSAEEDAAQFLKDEAKRGRKKPM
EEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
AGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPARLGTTLVEAIKG
EEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]