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The map label for this gene is tesB [H]

Identifier: 13473596

GI number: 13473596

Start: 3390007

End: 3390867

Strand: Reverse

Name: tesB [H]

Synonym: mll4250

Alternate gene names: 13473596

Gene position: 3390867-3390007 (Counterclockwise)

Preceding gene: 13473598

Following gene: 13473595

Centisome position: 48.19

GC content: 66.09

Gene sequence:

>861_bases
ATGACGGCGGCGATCGACGAGCTTCTGAGCATTCTCGACCTCGAGAGGCTGGAACACAATCTGTATCGTGGTCGCAGCCC
CCAGGTGGAGTGGCAGCGCGTCTTCGGCGGCCAGACCATCGCCCAGGCGCTTGTGGCGGCGCAGCGGACGGTGGAACCGG
ACCGCTTCGTGCATTCGCTGCACGGCTATTTCATGCGGCCGGGCGACATCAGGGTGCCGATCGTCTACGAGGTCGACCGC
ATCCGCGACGGCGGCTCCTTCACCACCCGGCGCGTGCTGGCGATCCAGCACGGACAGGCGATCTTTTCGCTGGAAGCCTC
GTTCCAGGTCGACGAAAAGGGGCTGGAACACCAATTCGCACTGCCTGACGACGTGCCGCCGCCGGAAGGGCTGCCGACGC
AGCGCCAGCTGCTCGAAAGAGCCGAACGTGTGCCGGAGGCGGTGCGCCGCTTCTGGGCACGCGAACGGCCGCTGGAGCTC
AGGCCGGTCAATCTCCAGCACTATGAAAGCCGCGACAAGCTGCCGCCCCGGCAGAATGTCTGGATCCGCCTTGCCGGCCC
GGTTCCCGATGACCGCGCGCTGCAATCGGTGCTGCTCGCCTATCTCTCCGACATGACGCTGCTGGACACCTCGACCTTCG
CGCATGGACGTGGCCTGTTCGATCCCGACATCCAGGCGGCGAGTCTCGACCATTCGATGTGGTTCCACCGGCCGCACTCG
CTCGACGGCTGGCTGCTCTATGCGCAGGACAGCCCATCGAGCTCGGGATCGCGCGGCTTCAGTCGAGGCACGCTCTATGC
GCGCGACGGCACGCTGATCGCCTCGATGGCCCAGGAAGGGTTGATCCGGCTCAAGCGTTGA

Upstream 100 bases:

>100_bases
TTGTCTTGGCTCCTTGCGCGCCGGCCCGGACCTGCGCCCTTGACGGCTCGTTCTTCCTGTCGGAAACCGCCATAGCAATT
TTGCGGCGAGGTCACAAAAC

Downstream 100 bases:

>100_bases
GCATTGCGAGTCTTGTTTGAGCAGGATCACTGACAAACGAAAACCGTTTGTCCGGGAAAACCCGGCTCGGCTTTTCGGGA
TCGTGCTCAAAGCCGGCAAA

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTAAIDELLSILDLERLEHNLYRGRSPQVEWQRVFGGQTIAQALVAAQRTVEPDRFVHSLHGYFMRPGDIRVPIVYEVDR
IRDGGSFTTRRVLAIQHGQAIFSLEASFQVDEKGLEHQFALPDDVPPPEGLPTQRQLLERAERVPEAVRRFWARERPLEL
RPVNLQHYESRDKLPPRQNVWIRLAGPVPDDRALQSVLLAYLSDMTLLDTSTFAHGRGLFDPDIQAASLDHSMWFHRPHS
LDGWLLYAQDSPSSSGSRGFSRGTLYARDGTLIASMAQEGLIRLKR

Sequences:

>Translated_286_residues
MTAAIDELLSILDLERLEHNLYRGRSPQVEWQRVFGGQTIAQALVAAQRTVEPDRFVHSLHGYFMRPGDIRVPIVYEVDR
IRDGGSFTTRRVLAIQHGQAIFSLEASFQVDEKGLEHQFALPDDVPPPEGLPTQRQLLERAERVPEAVRRFWARERPLEL
RPVNLQHYESRDKLPPRQNVWIRLAGPVPDDRALQSVLLAYLSDMTLLDTSTFAHGRGLFDPDIQAASLDHSMWFHRPHS
LDGWLLYAQDSPSSSGSRGFSRGTLYARDGTLIASMAQEGLIRLKR
>Mature_285_residues
TAAIDELLSILDLERLEHNLYRGRSPQVEWQRVFGGQTIAQALVAAQRTVEPDRFVHSLHGYFMRPGDIRVPIVYEVDRI
RDGGSFTTRRVLAIQHGQAIFSLEASFQVDEKGLEHQFALPDDVPPPEGLPTQRQLLERAERVPEAVRRFWARERPLELR
PVNLQHYESRDKLPPRQNVWIRLAGPVPDDRALQSVLLAYLSDMTLLDTSTFAHGRGLFDPDIQAASLDHSMWFHRPHSL
DGWLLYAQDSPSSSGSRGFSRGTLYARDGTLIASMAQEGLIRLKR

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=288, Percent_Identity=41.3194444444444, Blast_Score=221, Evalue=7e-58,
Organism=Escherichia coli, GI1786657, Length=284, Percent_Identity=46.830985915493, Blast_Score=262, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71988741, Length=290, Percent_Identity=39.3103448275862, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17558508, Length=305, Percent_Identity=36.7213114754098, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI115532456, Length=272, Percent_Identity=37.5, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17531889, Length=272, Percent_Identity=37.5, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17531885, Length=272, Percent_Identity=37.5, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI212645202, Length=264, Percent_Identity=36.3636363636364, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71982224, Length=298, Percent_Identity=31.2080536912752, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322480, Length=299, Percent_Identity=25.0836120401338, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32550; Mature: 32419

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAIDELLSILDLERLEHNLYRGRSPQVEWQRVFGGQTIAQALVAAQRTVEPDRFVHSL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHH
HGYFMRPGDIRVPIVYEVDRIRDGGSFTTRRVLAIQHGQAIFSLEASFQVDEKGLEHQFA
HHHEECCCCEEEEEEEEEECCCCCCCHHHEEEEEEECCCEEEEEECCCEECCCCCCCCCC
LPDDVPPPEGLPTQRQLLERAERVPEAVRRFWARERPLELRPVNLQHYESRDKLPPRQNV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHCHHCCCCCCCCE
WIRLAGPVPDDRALQSVLLAYLSDMTLLDTSTFAHGRGLFDPDIQAASLDHSMWFHRPHS
EEEEECCCCCHHHHHHHHHHHHCCCCEEECCCHHCCCCCCCCCCCHHCCCCHHHCCCCCC
LDGWLLYAQDSPSSSGSRGFSRGTLYARDGTLIASMAQEGLIRLKR
CCCEEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAAIDELLSILDLERLEHNLYRGRSPQVEWQRVFGGQTIAQALVAAQRTVEPDRFVHSL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHH
HGYFMRPGDIRVPIVYEVDRIRDGGSFTTRRVLAIQHGQAIFSLEASFQVDEKGLEHQFA
HHHEECCCCEEEEEEEEEECCCCCCCHHHEEEEEEECCCEEEEEECCCEECCCCCCCCCC
LPDDVPPPEGLPTQRQLLERAERVPEAVRRFWARERPLELRPVNLQHYESRDKLPPRQNV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHCHHCCCCCCCCE
WIRLAGPVPDDRALQSVLLAYLSDMTLLDTSTFAHGRGLFDPDIQAASLDHSMWFHRPHS
EEEEECCCCCHHHHHHHHHHHHCCCCEEECCCHHCCCCCCCCCCCHHCCCCHHHCCCCCC
LDGWLLYAQDSPSSSGSRGFSRGTLYARDGTLIASMAQEGLIRLKR
CCCEEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]