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The map label for this gene is gcp

Identifier: 13473578

GI number: 13473578

Start: 3374416

End: 3375504

Strand: Direct

Name: gcp

Synonym: mlr4224

Alternate gene names: 13473578

Gene position: 3374416-3375504 (Clockwise)

Preceding gene: 13473571

Following gene: 13473579

Centisome position: 47.96

GC content: 67.77

Gene sequence:

>1089_bases
TTGATCCGCGTTCTGGGCATTGAGACGAGTTGCGACGAGACCGCCGCCAGCGTCGTGGCGCTGGAGGGCGATGCCGCGCC
GAAAATCCTGTCCAACATCGTGCTTTCTCAGATCGAGGAACATGCCGCCTTCGGCGGTGTCGTGCCCGAGATCGCCGCCC
GCGCCCATGTCGAGGCGCTGGACGGCATCGTCGAGGCGGCGCTGGCGGATTCGGGCACAACCCTTGCCGATATCGATGCG
ATCGCCGCCACCGCTGGCCCCGGCCTGGTCGGCGGGCTGATCGTCGGGCTGATGACGGCCAAGGCGATCGCCGCCGCGGC
AGGCAAGCCGCTGATCGCCGTCAACCACCTTGAAGGCCATGCCTTGACGGCGCGGCTGACCGACGGGCTCGAATTTCCCT
ATTTGCTGCTGCTGGTCTCCGGCGGCCACACGCAGATCCTGGCGGTGCGCGGCGTCGGCGACTATCAGCGCTGGGCCACC
ACCATCGACGACGCGCTCGGCGAAGCCTTCGACAAGACCGCCAAGATGCTCGGCCTGCCCTATCCCGGCGGACCGAATGT
CGAGAAGGCAGCACAGACGGGCAATGCCTCACGCTTTACCTTCCCTCGCCCGATGAAAGGCTCGGCGCAGCCCGACTTCT
CCTTCTCCGGTTTGAAGACCGCCGTGCGCCAGGCGGCGACCGCGATCGAGCCGCTGGGCGACCAGGACGTCGCCGACATC
TGCGCCTCGTTCCAGGCGGCGGTCGCCGATGCGCTGGCCGACCGCGTTTCGCGCGCGCTGGCGCGATTCAGCCAGACATT
TCCCGGCACGAAAAACCCGGCTTTGGTCGTTGCCGGCGGCGTCGCCGCCAACCATACCATCAAGGCAACGCTGGAACGGC
TCTGCGCCGAGGCCGGTTTCATCTTCGTCGCGCCGCCGCTCAAACTGTGCACCGACAATGCCGCGATGATCGCCTGGGCC
GGCATCGAACGGCTGCGGGAAGGCATGGCGCAGGAGAACGGCTTCGATTTCGTGCCGCGCTCGCGCTGGCCGCTGGACAG
CATCTCGGCGCCGATGGTCGGTTCCGGCCGGCGCGGAGCCAAGGCATGA

Upstream 100 bases:

>100_bases
ACTTGGCGTCGCAGAAATGCGGCTAAGATAACCGAGGCCTTTCCGGGCCTTCTCCTAATGGGGAAAGGCTCGATAAACAA
TCTCTGGAGACAGCGACGAA

Downstream 100 bases:

>100_bases
CAGGTGAAGCGGTGAGCGGCCAAGACGTCAGCAATCCCGGCAAAAGCAGCTGGCGTGTCACCGTGCTGGGCGGCGGCGCC
TGGGGCACGGCGCTGGCGCT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MIRVLGIETSCDETAASVVALEGDAAPKILSNIVLSQIEEHAAFGGVVPEIAARAHVEALDGIVEAALADSGTTLADIDA
IAATAGPGLVGGLIVGLMTAKAIAAAAGKPLIAVNHLEGHALTARLTDGLEFPYLLLLVSGGHTQILAVRGVGDYQRWAT
TIDDALGEAFDKTAKMLGLPYPGGPNVEKAAQTGNASRFTFPRPMKGSAQPDFSFSGLKTAVRQAATAIEPLGDQDVADI
CASFQAAVADALADRVSRALARFSQTFPGTKNPALVVAGGVAANHTIKATLERLCAEAGFIFVAPPLKLCTDNAAMIAWA
GIERLREGMAQENGFDFVPRSRWPLDSISAPMVGSGRRGAKA

Sequences:

>Translated_362_residues
MIRVLGIETSCDETAASVVALEGDAAPKILSNIVLSQIEEHAAFGGVVPEIAARAHVEALDGIVEAALADSGTTLADIDA
IAATAGPGLVGGLIVGLMTAKAIAAAAGKPLIAVNHLEGHALTARLTDGLEFPYLLLLVSGGHTQILAVRGVGDYQRWAT
TIDDALGEAFDKTAKMLGLPYPGGPNVEKAAQTGNASRFTFPRPMKGSAQPDFSFSGLKTAVRQAATAIEPLGDQDVADI
CASFQAAVADALADRVSRALARFSQTFPGTKNPALVVAGGVAANHTIKATLERLCAEAGFIFVAPPLKLCTDNAAMIAWA
GIERLREGMAQENGFDFVPRSRWPLDSISAPMVGSGRRGAKA
>Mature_362_residues
MIRVLGIETSCDETAASVVALEGDAAPKILSNIVLSQIEEHAAFGGVVPEIAARAHVEALDGIVEAALADSGTTLADIDA
IAATAGPGLVGGLIVGLMTAKAIAAAAGKPLIAVNHLEGHALTARLTDGLEFPYLLLLVSGGHTQILAVRGVGDYQRWAT
TIDDALGEAFDKTAKMLGLPYPGGPNVEKAAQTGNASRFTFPRPMKGSAQPDFSFSGLKTAVRQAATAIEPLGDQDVADI
CASFQAAVADALADRVSRALARFSQTFPGTKNPALVVAGGVAANHTIKATLERLCAEAGFIFVAPPLKLCTDNAAMIAWA
GIERLREGMAQENGFDFVPRSRWPLDSISAPMVGSGRRGAKA

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=341, Percent_Identity=39.8826979472141, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI8923380, Length=328, Percent_Identity=33.8414634146341, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1789445, Length=353, Percent_Identity=49.8583569405099, Blast_Score=294, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17557464, Length=331, Percent_Identity=32.3262839879154, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI71995670, Length=334, Percent_Identity=32.9341317365269, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320099, Length=373, Percent_Identity=34.5844504021448, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322891, Length=378, Percent_Identity=26.984126984127, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI20129063, Length=355, Percent_Identity=34.9295774647887, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI21357207, Length=342, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_RHILO (Q98EI6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105146.1
- ProteinModelPortal:   Q98EI6
- SMR:   Q98EI6
- MEROPS:   M22.001
- GeneID:   1227807
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr4224
- NMPDR:   fig|266835.1.peg.3250
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37346; Mature: 37346

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVLGIETSCDETAASVVALEGDAAPKILSNIVLSQIEEHAAFGGVVPEIAARAHVEAL
CEEEEECCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
DGIVEAALADSGTTLADIDAIAATAGPGLVGGLIVGLMTAKAIAAAAGKPLIAVNHLEGH
HHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
ALTARLTDGLEFPYLLLLVSGGHTQILAVRGVGDYQRWATTIDDALGEAFDKTAKMLGLP
EEEEECCCCCCCCEEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
YPGGPNVEKAAQTGNASRFTFPRPMKGSAQPDFSFSGLKTAVRQAATAIEPLGDQDVADI
CCCCCCHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
CASFQAAVADALADRVSRALARFSQTFPGTKNPALVVAGGVAANHTIKATLERLCAEAGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCE
IFVAPPLKLCTDNAAMIAWAGIERLREGMAQENGFDFVPRSRWPLDSISAPMVGSGRRGA
EEECCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCC
KA
CC
>Mature Secondary Structure
MIRVLGIETSCDETAASVVALEGDAAPKILSNIVLSQIEEHAAFGGVVPEIAARAHVEAL
CEEEEECCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
DGIVEAALADSGTTLADIDAIAATAGPGLVGGLIVGLMTAKAIAAAAGKPLIAVNHLEGH
HHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
ALTARLTDGLEFPYLLLLVSGGHTQILAVRGVGDYQRWATTIDDALGEAFDKTAKMLGLP
EEEEECCCCCCCCEEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
YPGGPNVEKAAQTGNASRFTFPRPMKGSAQPDFSFSGLKTAVRQAATAIEPLGDQDVADI
CCCCCCHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
CASFQAAVADALADRVSRALARFSQTFPGTKNPALVVAGGVAANHTIKATLERLCAEAGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCE
IFVAPPLKLCTDNAAMIAWAGIERLREGMAQENGFDFVPRSRWPLDSISAPMVGSGRRGA
EEECCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCC
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968