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The map label for this gene is hexR [H]

Identifier: 13473521

GI number: 13473521

Start: 3318682

End: 3319563

Strand: Direct

Name: hexR [H]

Synonym: mlr4153

Alternate gene names: 13473521

Gene position: 3318682-3319563 (Clockwise)

Preceding gene: 13473520

Following gene: 13473524

Centisome position: 47.17

GC content: 65.19

Gene sequence:

>882_bases
ATGAAGACGCCGGCCGACATCATCACGCGGCTGCAACTGATGTCGCAGGACGGCACCAAGTCGGACCGCCGGTTGGCCGG
CCTTGTGCTGTCCGATCTCGATTTCGCTTCCAAGGCGGCAATCTCGGAGATTGCCGCGCGCGTCGGCGTCAGCGAACCGA
CGGTGACGCGCTTTTGCCGCAATCTCGGCTGCGAGGGCCTGCGCGACTTCAAATTTTACCTGGCCCAGGCCATCGCCATT
GGCGGCCAGTATCTGTCGCCCGAACCGCTGAGCCGCGACGCGCGTGAGCAACGCATCGCCTCGGCCATCACCGAAGCGGC
GATCTCTGCCATCCAGCGCGCCAGCGAGAACCTCGACATGACGACGCTGGTCGCCGTCGCCCAGCGGCTTGCGACGTCGG
GCAATGTGCTGTGCATCGGCTCTGGCGGCATCTCCTCGATGATGGCGACCGAGATGCAGAACCGGCTGTTCCGGCTCGGC
CTGCCGGTGCTGGCGCAGATCGACGGCCAGCTGCAGCGCATGTATGCCGCCGTTGCCACGCCAGAAACCACGCTGGTCGC
CTTTTCGGTGTCCGGCTATGCGCGCTCGGTCATCGAGGCGGTGCAGGTCGCCCAGCAATATGGCGCCACCACGGTCGCCA
TCACCGCGCCCGATTCGGCGCTGGCCAAGGCCGCCGACACGGTCATCCATTTGCAGCCGCTCGAGGACGGCAACATCTAC
AAGCCGACATCGTCGCGCTACGCGCTGCTGGCGATCGTCGACATGATCGTCACCTCGGTTGCCGAGACGCGCGGTCCGAA
AGTGCTGGAGAATTTGCGCCGCATCAAGCAGAGCGTGAACACGCTCAAGGTCGACGACCCAAGGCTGCCACTAGGGGATT
GA

Upstream 100 bases:

>100_bases
CGGTCTCGGTCGATCCCGGCAACATCCATCTGTTCGACAAGGCGACGGGCCTGCCGCTATAAGGCCGAGAAGGCAACGGC
ATGAAGACGAAACAACAAAC

Downstream 100 bases:

>100_bases
GAGGGCGAGCGCGCCGGGCGAAGACCCCCTCACCCGGATTGCCAACCGAATTGCAAAGGGCAATTCAGGACAATCCGACC
CTTCCCCGAGGGGAGAGGAG

Product: transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKTPADIITRLQLMSQDGTKSDRRLAGLVLSDLDFASKAAISEIAARVGVSEPTVTRFCRNLGCEGLRDFKFYLAQAIAI
GGQYLSPEPLSRDAREQRIASAITEAAISAIQRASENLDMTTLVAVAQRLATSGNVLCIGSGGISSMMATEMQNRLFRLG
LPVLAQIDGQLQRMYAAVATPETTLVAFSVSGYARSVIEAVQVAQQYGATTVAITAPDSALAKAADTVIHLQPLEDGNIY
KPTSSRYALLAIVDMIVTSVAETRGPKVLENLRRIKQSVNTLKVDDPRLPLGD

Sequences:

>Translated_293_residues
MKTPADIITRLQLMSQDGTKSDRRLAGLVLSDLDFASKAAISEIAARVGVSEPTVTRFCRNLGCEGLRDFKFYLAQAIAI
GGQYLSPEPLSRDAREQRIASAITEAAISAIQRASENLDMTTLVAVAQRLATSGNVLCIGSGGISSMMATEMQNRLFRLG
LPVLAQIDGQLQRMYAAVATPETTLVAFSVSGYARSVIEAVQVAQQYGATTVAITAPDSALAKAADTVIHLQPLEDGNIY
KPTSSRYALLAIVDMIVTSVAETRGPKVLENLRRIKQSVNTLKVDDPRLPLGD
>Mature_293_residues
MKTPADIITRLQLMSQDGTKSDRRLAGLVLSDLDFASKAAISEIAARVGVSEPTVTRFCRNLGCEGLRDFKFYLAQAIAI
GGQYLSPEPLSRDAREQRIASAITEAAISAIQRASENLDMTTLVAVAQRLATSGNVLCIGSGGISSMMATEMQNRLFRLG
LPVLAQIDGQLQRMYAAVATPETTLVAFSVSGYARSVIEAVQVAQQYGATTVAITAPDSALAKAADTVIHLQPLEDGNIY
KPTSSRYALLAIVDMIVTSVAETRGPKVLENLRRIKQSVNTLKVDDPRLPLGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=288, Percent_Identity=30.2083333333333, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI87082369, Length=251, Percent_Identity=23.9043824701195, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31385; Mature: 31385

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPADIITRLQLMSQDGTKSDRRLAGLVLSDLDFASKAAISEIAARVGVSEPTVTRFCR
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHH
NLGCEGLRDFKFYLAQAIAIGGQYLSPEPLSRDAREQRIASAITEAAISAIQRASENLDM
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TTLVAVAQRLATSGNVLCIGSGGISSMMATEMQNRLFRLGLPVLAQIDGQLQRMYAAVAT
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
PETTLVAFSVSGYARSVIEAVQVAQQYGATTVAITAPDSALAKAADTVIHLQPLEDGNIY
CCEEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHEEEEEECCCCCEE
KPTSSRYALLAIVDMIVTSVAETRGPKVLENLRRIKQSVNTLKVDDPRLPLGD
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEECCCCCCCCCC
>Mature Secondary Structure
MKTPADIITRLQLMSQDGTKSDRRLAGLVLSDLDFASKAAISEIAARVGVSEPTVTRFCR
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHH
NLGCEGLRDFKFYLAQAIAIGGQYLSPEPLSRDAREQRIASAITEAAISAIQRASENLDM
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TTLVAVAQRLATSGNVLCIGSGGISSMMATEMQNRLFRLGLPVLAQIDGQLQRMYAAVAT
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
PETTLVAFSVSGYARSVIEAVQVAQQYGATTVAITAPDSALAKAADTVIHLQPLEDGNIY
CCEEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHEEEEEECCCCCEE
KPTSSRYALLAIVDMIVTSVAETRGPKVLENLRRIKQSVNTLKVDDPRLPLGD
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]