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The map label for this gene is qor [C]

Identifier: 13471972

GI number: 13471972

Start: 1728202

End: 1729206

Strand: Reverse

Name: qor [C]

Synonym: mll2116

Alternate gene names: 13471972

Gene position: 1729206-1728202 (Counterclockwise)

Preceding gene: 13471973

Following gene: 13471968

Centisome position: 24.58

GC content: 59.9

Gene sequence:

>1005_bases
ATGATGAAAGCCTTTGTTGTCGACAAGTATCAAAAGAAGGGCGCCCTGCGGCTCGCCGAGATGCCGGAACCCGAGTTGCG
GGACAATGATGTCCTGGTCGAAATTCACGCCGCCGGGGTGAACCTTCTCGATTCCAAGCTTCGGGATGGGGAGTTCAAGC
CGATATTGCCCTATCGCCCGCCGTTCATCCTGGGCCATGACGTGGCAGGGATCGTCGTGCGGGCCGGATCGAAAGCTCGC
AAATTCAAGCTCGGTGACGAAGTCTATGCGCGGTCGCGCGACGGGCGGATCGGCACGTTTGCCCAATCCATCGCCATGGA
TGAAGCCGACGTGGCGCTGAAGCCAAAAAACCTCAGCATGGAAGAAGCCGCCTCGATCCCGCTGGTGGGCCTGACCGCCT
GGCAGGTGCTGGTCGAGACAGCCGGGCTGAAGAAGGGCCAGAAGGTGTTTATCCAGGCCGGCTCGGGCGGAGTGGGGACC
TTCGCCATCCAACTGGCGAAGCATCTCGGCGCGACCGTCGCGACGACGGCGAGCGCGGCGAATGCCGATCTGGTGAAAGG
TCTCGGAGCCGATATCGTCATCGACTACAAGAAAGACGATTTCGAGAAAATCCTGCAAGGCTACGACGTCGTCCTGAACA
GCCAGGACGCCAAAACGCTCGAAAAATCGCTGCATGTGCTGAAGCCGGGCGGGAAACTCATCTCCATTTCCGGCCCGCCG
GATCCCGATTTTGCCGGAAAGCAGAAGCTGAACATGGTCCTGAAGCTAGTCCTGCGCCTGCTGAGCCGCGGCATACGCAG
CAAGGCCAGACGTGCCGGTGTCGGATATTCTTTCCTGTTCATGTGGGCGCAGGGCGATCAGCTGGGCGAGATCACCTCGC
GCATCGAATCCGGCTTCATACGCCCTGTCATCGATCGGATTTTTCCGTTCGAGAAGACGAACGAGGCATTGGCCTACGTC
GAAGCGGGGCGTGCCAAGGGCAAGGTCGTCGTCAAGGTCAGATAG

Upstream 100 bases:

>100_bases
CAACATCGCCGATCTTGTCCGGCGTATCCGCGAGTGCGACCAGCGACGCCTTGCGGCTTGCCAGTTCGTGCCGGCCACCG
AAAACCATTAGAAAGCGATC

Downstream 100 bases:

>100_bases
GCGAGCGTTCGGCGACTATCTCCTTGTTCCCTTTGCGCCATTACGGACGCATGGTCGTTGCTTCAGCTAGCCGGTGGCTG
CCGGCGCCGTCTCGATCTCC

Product: zinc-binding oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MMKAFVVDKYQKKGALRLAEMPEPELRDNDVLVEIHAAGVNLLDSKLRDGEFKPILPYRPPFILGHDVAGIVVRAGSKAR
KFKLGDEVYARSRDGRIGTFAQSIAMDEADVALKPKNLSMEEAASIPLVGLTAWQVLVETAGLKKGQKVFIQAGSGGVGT
FAIQLAKHLGATVATTASAANADLVKGLGADIVIDYKKDDFEKILQGYDVVLNSQDAKTLEKSLHVLKPGGKLISISGPP
DPDFAGKQKLNMVLKLVLRLLSRGIRSKARRAGVGYSFLFMWAQGDQLGEITSRIESGFIRPVIDRIFPFEKTNEALAYV
EAGRAKGKVVVKVR

Sequences:

>Translated_334_residues
MMKAFVVDKYQKKGALRLAEMPEPELRDNDVLVEIHAAGVNLLDSKLRDGEFKPILPYRPPFILGHDVAGIVVRAGSKAR
KFKLGDEVYARSRDGRIGTFAQSIAMDEADVALKPKNLSMEEAASIPLVGLTAWQVLVETAGLKKGQKVFIQAGSGGVGT
FAIQLAKHLGATVATTASAANADLVKGLGADIVIDYKKDDFEKILQGYDVVLNSQDAKTLEKSLHVLKPGGKLISISGPP
DPDFAGKQKLNMVLKLVLRLLSRGIRSKARRAGVGYSFLFMWAQGDQLGEITSRIESGFIRPVIDRIFPFEKTNEALAYV
EAGRAKGKVVVKVR
>Mature_334_residues
MMKAFVVDKYQKKGALRLAEMPEPELRDNDVLVEIHAAGVNLLDSKLRDGEFKPILPYRPPFILGHDVAGIVVRAGSKAR
KFKLGDEVYARSRDGRIGTFAQSIAMDEADVALKPKNLSMEEAASIPLVGLTAWQVLVETAGLKKGQKVFIQAGSGGVGT
FAIQLAKHLGATVATTASAANADLVKGLGADIVIDYKKDDFEKILQGYDVVLNSQDAKTLEKSLHVLKPGGKLISISGPP
DPDFAGKQKLNMVLKLVLRLLSRGIRSKARRAGVGYSFLFMWAQGDQLGEITSRIESGFIRPVIDRIFPFEKTNEALAYV
EAGRAKGKVVVKVR

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=362, Percent_Identity=36.1878453038674, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI194239674, Length=342, Percent_Identity=27.1929824561404, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI13236495, Length=342, Percent_Identity=27.1929824561404, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI18379349, Length=318, Percent_Identity=27.9874213836478, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI22538446, Length=351, Percent_Identity=28.4900284900285, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI22538444, Length=351, Percent_Identity=28.4900284900285, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI194239676, Length=205, Percent_Identity=31.219512195122, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI24308257, Length=352, Percent_Identity=25, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI28557745, Length=338, Percent_Identity=28.4023668639053, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI41872631, Length=230, Percent_Identity=28.695652173913, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI90669511, Length=350, Percent_Identity=24.2857142857143, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790485, Length=238, Percent_Identity=34.0336134453782, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790045, Length=272, Percent_Identity=23.5294117647059, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71987554, Length=369, Percent_Identity=28.1842818428184, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17507255, Length=341, Percent_Identity=27.8592375366569, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988145, Length=231, Percent_Identity=26.8398268398268, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI212642053, Length=274, Percent_Identity=31.021897810219, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=270, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=297, Percent_Identity=28.6195286195286, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=296, Percent_Identity=25.3378378378378, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=246, Percent_Identity=30.8943089430894, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=301, Percent_Identity=24.2524916943522, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=216, Percent_Identity=25.462962962963, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324195, Length=263, Percent_Identity=28.5171102661597, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24581341, Length=364, Percent_Identity=29.9450549450549, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24581339, Length=364, Percent_Identity=29.9450549450549, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19920632, Length=232, Percent_Identity=29.3103448275862, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221330659, Length=232, Percent_Identity=29.3103448275862, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24581345, Length=235, Percent_Identity=28.936170212766, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36255; Mature: 36255

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKAFVVDKYQKKGALRLAEMPEPELRDNDVLVEIHAAGVNLLDSKLRDGEFKPILPYRP
CCCCHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCC
PFILGHDVAGIVVRAGSKARKFKLGDEVYARSRDGRIGTFAQSIAMDEADVALKPKNLSM
CEEECCCCEEEEEECCCCCCEEECCHHHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCCH
EEAASIPLVGLTAWQVLVETAGLKKGQKVFIQAGSGGVGTFAIQLAKHLGATVATTASAA
HHHCCCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCHHEECCCCC
NADLVKGLGADIVIDYKKDDFEKILQGYDVVLNSQDAKTLEKSLHVLKPGGKLISISGPP
CHHHHHCCCCCEEEECCCCHHHHHHCCHHEEECCCHHHHHHHHHHEECCCCEEEECCCCC
DPDFAGKQKLNMVLKLVLRLLSRGIRSKARRAGVGYSFLFMWAQGDQLGEITSRIESGFI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCH
RPVIDRIFPFEKTNEALAYVEAGRAKGKVVVKVR
HHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEC
>Mature Secondary Structure
MMKAFVVDKYQKKGALRLAEMPEPELRDNDVLVEIHAAGVNLLDSKLRDGEFKPILPYRP
CCCCHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCC
PFILGHDVAGIVVRAGSKARKFKLGDEVYARSRDGRIGTFAQSIAMDEADVALKPKNLSM
CEEECCCCEEEEEECCCCCCEEECCHHHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCCH
EEAASIPLVGLTAWQVLVETAGLKKGQKVFIQAGSGGVGTFAIQLAKHLGATVATTASAA
HHHCCCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCHHEECCCCC
NADLVKGLGADIVIDYKKDDFEKILQGYDVVLNSQDAKTLEKSLHVLKPGGKLISISGPP
CHHHHHCCCCCEEEECCCCHHHHHHCCHHEEECCCHHHHHHHHHHEECCCCEEEECCCCC
DPDFAGKQKLNMVLKLVLRLLSRGIRSKARRAGVGYSFLFMWAQGDQLGEITSRIESGFI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCH
RPVIDRIFPFEKTNEALAYVEAGRAKGKVVVKVR
HHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA