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The map label for this gene is coxN [H]

Identifier: 13471151

GI number: 13471151

Start: 875320

End: 877089

Strand: Direct

Name: coxN [H]

Synonym: mlr1041

Alternate gene names: 13471151

Gene position: 875320-877089 (Clockwise)

Preceding gene: 13471150

Following gene: 13471152

Centisome position: 12.44

GC content: 61.36

Gene sequence:

>1770_bases
ATGGTCGACATCACCCCTGCAGATGGCATTCCGCCGGCCGAAGTCGCGGAAGTCGAACTCTACCATCCGCACAGTTGGTG
GACCAAATACGTCTTTTCGCAGGACGCCAAGGTCATCGCCGTCCAGTATTCGGCGACGGCAACGGCAATCGGCCTGGTCG
CCCTGGTGCTGTCCTGGCTGATGCGGCTGCAGCTTGGCTTTCCCGGCACGTTCGACTTCATCACCCCGGAGGCCTACTAC
CAGTTCATCACCATGCACGGCATGATCATGGTGATCTACCTGCTCACCGCCCTCTTCCTCGGCGGCTTTGGCAACTATCT
GATCCCCTTGATGGTCGGCGCGCGCGACATGGTCTTCCCCTATGTCAACATGCTGAGCTACTGGATCTACCTGCTTGCCG
TGCTGGTTCTGGTGTCGAGCTTCTTCGCGCCCGGCGGACCGACGGGGGCCGGCTGGACGCTCTACCCGCCGCAGGCCATC
ATGAGCGGGACGCCAGGCGGCCAGGACTGGGGCATCATCCTGATGCTCTCCTCGCTGATCCTGTTCATCATCGGCTTCAC
GATGGGTGGCCTCAACTATGTCGTGACCGTGCTGCAGGGCCGCACGCGCGGCATGACGATGATGCGCCTGCCGCTGACCG
TCTGGGGCATCTTCACCGCAACCGTCATGGCGCTGCTCGCCTTTCCGGCGCTGTTCGTCGCCAGCGTGATGATGCTGCTC
GACCGCGTCCTGGGCACCAGCTTCTTCATGCCGGCGATCTCTGAAATGGGTGAGCAGCTGCAACACAATGGCGGCAGCCC
GATCCTGTTCCAGCACCTGTTCTGGTTCTTCGGCCATCCCGAGGTCTACATCGTGGCGCTGCCGGCCTTCGGCATCGTAT
CCGACCTGATCAGCACCCATGCGCGCAAGAACATCTTCGGCTACCGGATGATGGTCTGGGCCATCGTCGGCATTGGCGCG
CTGAGCTTCGTGGTCTGGGCGCACCACATGTATGTCAGCGGCATGCACCCCTATTTCGGCTTCTTCTTCGCCACCACGAC
GCTGATCATCGCCATTCCGACGGCCATCAAGGTCTACAATTGGGTGCTGACCCTATGGCGCGGCGACATCCATCTCACCA
TACCAATGTTGTTCGCCCTGGCCTTCATAGTGACCTTCGTCAACGGCGGGCTGACCGGCCTGTTCCTTGGCAATGTCGTC
GTCGATGTTCCGCTATCCGACACGATGTTCGTCGTCGCCCATTTCCATATGGTCATGGGTGTCGCCCCGATCCTCGTGGT
TTTTGGCGCGATCTACCATTGGTACCCGAAGGTCACCGGCCGGATGCTCGACGAAACCCTGGGCCGGTTCCATTTCTGGG
TCACCTTCCTCGGCGCCTACCTGATTTTCTTCCCCATGCACTACCTCGGCCTGATGGGCGTGCCGCGGCGCTATGCTGAA
CTGACCGACATGACGATCATGACGGAGTCGGCCCATCACCTGAACTCGTTCATCAGCGTCATGGCCTTCATCGTCGGCTT
CGCCCAGATGGTGTTCCTGTTCAACCTGATCTGGAGCATCCGCCATGGCCGCGAGGCCGGCGGCAATCCGTGGCGGGCCA
CGACCCTCGAATGGCAGACGCCGCAAACACCGCCGGCCCACGGCAATTTCGGCAAGGACCTGCCGATCGTCTATCGCTGG
GCTTATGATTACAGCGTACCGGGCGCCAAGGAAGACTTCATCCCGCAGAACATGCCGGGCTCCTTCGGCCCCTCAAGGGA
GCCGGCATGA

Upstream 100 bases:

>100_bases
GCGGACGAGACGACGGGACGGACGGCGGCACCGGGTCCCGAAATTGCAGCAAGGCTCGAAACGGTCGGGTCTCGCTGAAA
AAGGACACGGAGGTGTTCCT

Downstream 100 bases:

>100_bases
GCGTCATCCTGGTCTTCCTGCTCGTCATTGCCGGTTTTGCCGGATGGTGGCTTTCGCACCAGAGGCTGATGGCGAAGCCA
TGGCTCGAGCAAGGTCTGGC

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide I; Cytochrome BB3 subunit 1; Oxidase BB(3) subunit 1 [H]

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MVDITPADGIPPAEVAEVELYHPHSWWTKYVFSQDAKVIAVQYSATATAIGLVALVLSWLMRLQLGFPGTFDFITPEAYY
QFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYVNMLSYWIYLLAVLVLVSSFFAPGGPTGAGWTLYPPQAI
MSGTPGGQDWGIILMLSSLILFIIGFTMGGLNYVVTVLQGRTRGMTMMRLPLTVWGIFTATVMALLAFPALFVASVMMLL
DRVLGTSFFMPAISEMGEQLQHNGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVGIGA
LSFVVWAHHMYVSGMHPYFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGNVV
VDVPLSDTMFVVAHFHMVMGVAPILVVFGAIYHWYPKVTGRMLDETLGRFHFWVTFLGAYLIFFPMHYLGLMGVPRRYAE
LTDMTIMTESAHHLNSFISVMAFIVGFAQMVFLFNLIWSIRHGREAGGNPWRATTLEWQTPQTPPAHGNFGKDLPIVYRW
AYDYSVPGAKEDFIPQNMPGSFGPSREPA

Sequences:

>Translated_589_residues
MVDITPADGIPPAEVAEVELYHPHSWWTKYVFSQDAKVIAVQYSATATAIGLVALVLSWLMRLQLGFPGTFDFITPEAYY
QFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYVNMLSYWIYLLAVLVLVSSFFAPGGPTGAGWTLYPPQAI
MSGTPGGQDWGIILMLSSLILFIIGFTMGGLNYVVTVLQGRTRGMTMMRLPLTVWGIFTATVMALLAFPALFVASVMMLL
DRVLGTSFFMPAISEMGEQLQHNGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVGIGA
LSFVVWAHHMYVSGMHPYFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGNVV
VDVPLSDTMFVVAHFHMVMGVAPILVVFGAIYHWYPKVTGRMLDETLGRFHFWVTFLGAYLIFFPMHYLGLMGVPRRYAE
LTDMTIMTESAHHLNSFISVMAFIVGFAQMVFLFNLIWSIRHGREAGGNPWRATTLEWQTPQTPPAHGNFGKDLPIVYRW
AYDYSVPGAKEDFIPQNMPGSFGPSREPA
>Mature_589_residues
MVDITPADGIPPAEVAEVELYHPHSWWTKYVFSQDAKVIAVQYSATATAIGLVALVLSWLMRLQLGFPGTFDFITPEAYY
QFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYVNMLSYWIYLLAVLVLVSSFFAPGGPTGAGWTLYPPQAI
MSGTPGGQDWGIILMLSSLILFIIGFTMGGLNYVVTVLQGRTRGMTMMRLPLTVWGIFTATVMALLAFPALFVASVMMLL
DRVLGTSFFMPAISEMGEQLQHNGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVGIGA
LSFVVWAHHMYVSGMHPYFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGNVV
VDVPLSDTMFVVAHFHMVMGVAPILVVFGAIYHWYPKVTGRMLDETLGRFHFWVTFLGAYLIFFPMHYLGLMGVPRRYAE
LTDMTIMTESAHHLNSFISVMAFIVGFAQMVFLFNLIWSIRHGREAGGNPWRATTLEWQTPQTPPAHGNFGKDLPIVYRW
AYDYSVPGAKEDFIPQNMPGSFGPSREPA

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=521, Percent_Identity=38.5796545105566, Blast_Score=329, Evalue=4e-90,
Organism=Escherichia coli, GI1786634, Length=524, Percent_Identity=36.0687022900763, Blast_Score=316, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6226519, Length=475, Percent_Identity=40.4210526315789, Blast_Score=352, Evalue=9e-98,
Organism=Saccharomyces cerevisiae, GI6226524, Length=337, Percent_Identity=40.0593471810089, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6226523, Length=259, Percent_Identity=37.0656370656371, Blast_Score=150, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 65786; Mature: 65786

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDITPADGIPPAEVAEVELYHPHSWWTKYVFSQDAKVIAVQYSATATAIGLVALVLSWL
CCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH
MRLQLGFPGTFDFITPEAYYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHH
YVNMLSYWIYLLAVLVLVSSFFAPGGPTGAGWTLYPPQAIMSGTPGGQDWGIILMLSSLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHCCCCCCCCHHHHHHHHHHH
LFIIGFTMGGLNYVVTVLQGRTRGMTMMRLPLTVWGIFTATVMALLAFPALFVASVMMLL
HHHHHHHHCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRVLGTSFFMPAISEMGEQLQHNGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTH
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHH
ARKNIFGYRMMVWAIVGIGALSFVVWAHHMYVSGMHPYFGFFFATTTLIIAIPTAIKVYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGNVVVDVPLSDTMFVVAHFHMVMG
HHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHEECCCEEEECCCCCHHHHHHHHHHHHH
VAPILVVFGAIYHWYPKVTGRMLDETLGRFHFWVTFLGAYLIFFPMHYLGLMGVPRRYAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LTDMTIMTESAHHLNSFISVMAFIVGFAQMVFLFNLIWSIRHGREAGGNPWRATTLEWQT
HHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
PQTPPAHGNFGKDLPIVYRWAYDYSVPGAKEDFIPQNMPGSFGPSREPA
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVDITPADGIPPAEVAEVELYHPHSWWTKYVFSQDAKVIAVQYSATATAIGLVALVLSWL
CCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH
MRLQLGFPGTFDFITPEAYYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHH
YVNMLSYWIYLLAVLVLVSSFFAPGGPTGAGWTLYPPQAIMSGTPGGQDWGIILMLSSLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHCCCCCCCCHHHHHHHHHHH
LFIIGFTMGGLNYVVTVLQGRTRGMTMMRLPLTVWGIFTATVMALLAFPALFVASVMMLL
HHHHHHHHCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRVLGTSFFMPAISEMGEQLQHNGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTH
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHH
ARKNIFGYRMMVWAIVGIGALSFVVWAHHMYVSGMHPYFGFFFATTTLIIAIPTAIKVYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGNVVVDVPLSDTMFVVAHFHMVMG
HHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHEECCCEEEECCCCCHHHHHHHHHHHHH
VAPILVVFGAIYHWYPKVTGRMLDETLGRFHFWVTFLGAYLIFFPMHYLGLMGVPRRYAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LTDMTIMTESAHHLNSFISVMAFIVGFAQMVFLFNLIWSIRHGREAGGNPWRATTLEWQT
HHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
PQTPPAHGNFGKDLPIVYRWAYDYSVPGAKEDFIPQNMPGSFGPSREPA
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]