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The map label for this gene is alkJ [H]

Identifier: 13471123

GI number: 13471123

Start: 833541

End: 835154

Strand: Reverse

Name: alkJ [H]

Synonym: mll1008

Alternate gene names: 13471123

Gene position: 835154-833541 (Counterclockwise)

Preceding gene: 13471124

Following gene: 13471122

Centisome position: 11.87

GC content: 60.97

Gene sequence:

>1614_bases
ATGTGGGATTACATAATTGTCGGCGCGGGCTCGGCCGGTTGCGTGCTGGCAAACCGCCTGTCAGAGGATCCTGACGTCAA
GGTCCTGCTGCTGGAGGCTGGCAGCCGGGATTGGAATCCGATGATCCATATTCCCGGCGGCATCGGCAAGCTGTTCGGGC
CGGGCGTCAACTGGCGGTTCCACACGGTGCCGCAGAAGAACCTCGACAACCGCTCCATCTGGTATCCGCAAGGCAAGACC
CTTGGCGGCTCAAGCTCGATCAACGCGATGATCTACATCCGATGCCAAAAGGAAGACTATGACAATTGGGCAGCACTCGG
AAACGACGGATGGGCTTATGAGGATGTCTTGCCCTATTTCCGTAAATCCGAGGACAATGATCGGCTCGCCAATCGCTATC
ACGGGCTGGGCGGTCCGCTCGCAGTTTCGGATCAGGTCGGTCCGCACCCATTGACCCGGGCATTTGTCCGTGCCGTGCAA
CAATATGGCCTGCCGTTCAATCCCGACTTCAACGGCGACACCATGTATGGCGCCGGCTTCTACCAGGTCACCTGTCGCGA
TGGCCGCCGCCGCTCGTCCGCCGTCTCCTATCTGCATCCCGTCAGCAGGCGGCCCAACTTGACAGTCAGGACCCATGCCC
GAGTCACAAGGATCGTTGTCGAGAACGGCCGCGCCGTCGGCGTCGAACTTTCCGAGGGCAAATCGCGGAAAGTACTCCGG
GCCGAAAGCGAGGTAATCGTATCGGCAGGAGCCATCAACTCGCCGCGCCTGCTGATGCTGTCCGGTATCGGCCCGGCCGA
CAAGTTGCAAGCTCTCGGGATCGCTCCGGTCGCCGATCTCAGCGGTGTCGGTCGGAACCTCCAGGATCATCTCTGCACCA
ATGTCCATCTGACGCTCAAGGACCCAATCAGCTATGACGGCCAGGATCGCTATCCCAAGGCGCTCCTGCACGGCATTCGC
TGGCTGCTCTATCGCAATGGCCCTGCCGCCTCGGTCATTGTCGAGGGCGGCGGCTTCTTCCAGAGCGAGGGAGCGAAGCG
GCCCGACCTTCAGATTCACATCGCGCCGGCGATGGTGGTACGCGGCGGTCAGACGCGGCTCGACGGGCATGGTTTTACCA
TCAACTCGACATTCCTTCGACCACGTAGCATCGGCTCGGTGGAGGTCCGCTCTTCGAACCCCGCCGACGAGCCGCTGGTT
GACCCCAACTATCTTTCTGACCCATACGATCGCGGCATGGCATTGAAATCAGTACGGATCATCCGGGACGTGCTGGCGCA
AAGCGAAATCGCCAAGTTCGTCAAGGTCGAGCGGCTGCCTGGGCCGGCTGCGAAGACCGACGAGGAATTGATGGCCTACA
TCAGGCAATATGCCTGCTGCGACTATCACCCTGTTGGCACCTGCAAGATGGGCGTCGACGAGACCGCAGTCGTCGATCCC
GAACTGCGTGTGCGCGGAGTCGACGGACTGCGGGTGATCGACTCATCGATCATGCCGGTGCTGATCAGCGGCAACACCAA
TGGACCGACGATGATGATCGGCGAAAAAGGCGCCGATCTGGTGAAGGGCGTCCAGTCTGGTCGCTCCGCACAAGCGATCG
CGGCAGTCGCGTAA

Upstream 100 bases:

>100_bases
GCGCCGGCCTTCAGGGGCAAATAGGACTGAGGAGCCAGGTCCGCCAGGGGTTCGTTGCGCGGACGGAGAAGGCGCCTTCG
GGCGCGAGTGGAGGCAGAAC

Downstream 100 bases:

>100_bases
GTTTCTGGAGACCGGACCGATGCAATTCCTCGTCTTGTCTCGGCGCCGGACCGACCAATTCAGCGAAGCGGATTTCGAAC
AGCTGGTACCCAGCGAGGGG

Product: dehydrogenase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MWDYIIVGAGSAGCVLANRLSEDPDVKVLLLEAGSRDWNPMIHIPGGIGKLFGPGVNWRFHTVPQKNLDNRSIWYPQGKT
LGGSSSINAMIYIRCQKEDYDNWAALGNDGWAYEDVLPYFRKSEDNDRLANRYHGLGGPLAVSDQVGPHPLTRAFVRAVQ
QYGLPFNPDFNGDTMYGAGFYQVTCRDGRRRSSAVSYLHPVSRRPNLTVRTHARVTRIVVENGRAVGVELSEGKSRKVLR
AESEVIVSAGAINSPRLLMLSGIGPADKLQALGIAPVADLSGVGRNLQDHLCTNVHLTLKDPISYDGQDRYPKALLHGIR
WLLYRNGPAASVIVEGGGFFQSEGAKRPDLQIHIAPAMVVRGGQTRLDGHGFTINSTFLRPRSIGSVEVRSSNPADEPLV
DPNYLSDPYDRGMALKSVRIIRDVLAQSEIAKFVKVERLPGPAAKTDEELMAYIRQYACCDYHPVGTCKMGVDETAVVDP
ELRVRGVDGLRVIDSSIMPVLISGNTNGPTMMIGEKGADLVKGVQSGRSAQAIAAVA

Sequences:

>Translated_537_residues
MWDYIIVGAGSAGCVLANRLSEDPDVKVLLLEAGSRDWNPMIHIPGGIGKLFGPGVNWRFHTVPQKNLDNRSIWYPQGKT
LGGSSSINAMIYIRCQKEDYDNWAALGNDGWAYEDVLPYFRKSEDNDRLANRYHGLGGPLAVSDQVGPHPLTRAFVRAVQ
QYGLPFNPDFNGDTMYGAGFYQVTCRDGRRRSSAVSYLHPVSRRPNLTVRTHARVTRIVVENGRAVGVELSEGKSRKVLR
AESEVIVSAGAINSPRLLMLSGIGPADKLQALGIAPVADLSGVGRNLQDHLCTNVHLTLKDPISYDGQDRYPKALLHGIR
WLLYRNGPAASVIVEGGGFFQSEGAKRPDLQIHIAPAMVVRGGQTRLDGHGFTINSTFLRPRSIGSVEVRSSNPADEPLV
DPNYLSDPYDRGMALKSVRIIRDVLAQSEIAKFVKVERLPGPAAKTDEELMAYIRQYACCDYHPVGTCKMGVDETAVVDP
ELRVRGVDGLRVIDSSIMPVLISGNTNGPTMMIGEKGADLVKGVQSGRSAQAIAAVA
>Mature_537_residues
MWDYIIVGAGSAGCVLANRLSEDPDVKVLLLEAGSRDWNPMIHIPGGIGKLFGPGVNWRFHTVPQKNLDNRSIWYPQGKT
LGGSSSINAMIYIRCQKEDYDNWAALGNDGWAYEDVLPYFRKSEDNDRLANRYHGLGGPLAVSDQVGPHPLTRAFVRAVQ
QYGLPFNPDFNGDTMYGAGFYQVTCRDGRRRSSAVSYLHPVSRRPNLTVRTHARVTRIVVENGRAVGVELSEGKSRKVLR
AESEVIVSAGAINSPRLLMLSGIGPADKLQALGIAPVADLSGVGRNLQDHLCTNVHLTLKDPISYDGQDRYPKALLHGIR
WLLYRNGPAASVIVEGGGFFQSEGAKRPDLQIHIAPAMVVRGGQTRLDGHGFTINSTFLRPRSIGSVEVRSSNPADEPLV
DPNYLSDPYDRGMALKSVRIIRDVLAQSEIAKFVKVERLPGPAAKTDEELMAYIRQYACCDYHPVGTCKMGVDETAVVDP
ELRVRGVDGLRVIDSSIMPVLISGNTNGPTMMIGEKGADLVKGVQSGRSAQAIAAVA

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=535, Percent_Identity=43.9252336448598, Blast_Score=441, Evalue=1e-123,
Organism=Escherichia coli, GI1786503, Length=534, Percent_Identity=42.1348314606742, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17532301, Length=543, Percent_Identity=37.9373848987109, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24642042, Length=564, Percent_Identity=41.3120567375887, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24642059, Length=564, Percent_Identity=39.0070921985816, Blast_Score=341, Evalue=7e-94,
Organism=Drosophila melanogaster, GI24642048, Length=565, Percent_Identity=39.4690265486726, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24642055, Length=575, Percent_Identity=39.6521739130435, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI45551458, Length=576, Percent_Identity=37.1527777777778, Blast_Score=334, Evalue=8e-92,
Organism=Drosophila melanogaster, GI45549471, Length=576, Percent_Identity=37.1527777777778, Blast_Score=334, Evalue=9e-92,
Organism=Drosophila melanogaster, GI18859995, Length=564, Percent_Identity=39.0070921985816, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI17137792, Length=551, Percent_Identity=36.6606170598911, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24642039, Length=562, Percent_Identity=37.3665480427046, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24642037, Length=570, Percent_Identity=36.8421052631579, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24650267, Length=566, Percent_Identity=34.0989399293286, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI18859993, Length=568, Percent_Identity=35.0352112676056, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24642035, Length=570, Percent_Identity=35.4385964912281, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24642051, Length=574, Percent_Identity=32.0557491289199, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24642057, Length=575, Percent_Identity=32.8695652173913, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24645930, Length=583, Percent_Identity=28.3018867924528, Blast_Score=156, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 58508; Mature: 58508

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWDYIIVGAGSAGCVLANRLSEDPDVKVLLLEAGSRDWNPMIHIPGGIGKLFGPGVNWRF
CCEEEEEECCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCEEECCCCCHHHCCCCCCCEE
HTVPQKNLDNRSIWYPQGKTLGGSSSINAMIYIRCQKEDYDNWAALGNDGWAYEDVLPYF
EECCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCHHHHHHHH
RKSEDNDRLANRYHGLGGPLAVSDQVGPHPLTRAFVRAVQQYGLPFNPDFNGDTMYGAGF
HCCCCCHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCE
YQVTCRDGRRRSSAVSYLHPVSRRPNLTVRTHARVTRIVVENGRAVGVELSEGKSRKVLR
EEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCEEEEEEEECCCEEEEEECCCCCCCEEE
AESEVIVSAGAINSPRLLMLSGIGPADKLQALGIAPVADLSGVGRNLQDHLCTNVHLTLK
CCCEEEEEECCCCCCCEEEEECCCCHHHHHHCCCCCHHHHHHCCCCHHHHHCCEEEEEEE
DPISYDGQDRYPKALLHGIRWLLYRNGPAASVIVEGGGFFQSEGAKRPDLQIHIAPAMVV
CCCCCCCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCEECCCCCCCCCEEEEEECEEEE
RGGQTRLDGHGFTINSTFLRPRSIGSVEVRSSNPADEPLVDPNYLSDPYDRGMALKSVRI
ECCCEEECCCCEEEECEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCHHHHHHHH
IRDVLAQSEIAKFVKVERLPGPAAKTDEELMAYIRQYACCDYHPVGTCKMGVDETAVVDP
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEECC
ELRVRGVDGLRVIDSSIMPVLISGNTNGPTMMIGEKGADLVKGVQSGRSAQAIAAVA
CEEEECCCCCEEECCCCCEEEEECCCCCCEEEEECCCCHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MWDYIIVGAGSAGCVLANRLSEDPDVKVLLLEAGSRDWNPMIHIPGGIGKLFGPGVNWRF
CCEEEEEECCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCEEECCCCCHHHCCCCCCCEE
HTVPQKNLDNRSIWYPQGKTLGGSSSINAMIYIRCQKEDYDNWAALGNDGWAYEDVLPYF
EECCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCHHHHHHHH
RKSEDNDRLANRYHGLGGPLAVSDQVGPHPLTRAFVRAVQQYGLPFNPDFNGDTMYGAGF
HCCCCCHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCE
YQVTCRDGRRRSSAVSYLHPVSRRPNLTVRTHARVTRIVVENGRAVGVELSEGKSRKVLR
EEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCEEEEEEEECCCEEEEEECCCCCCCEEE
AESEVIVSAGAINSPRLLMLSGIGPADKLQALGIAPVADLSGVGRNLQDHLCTNVHLTLK
CCCEEEEEECCCCCCCEEEEECCCCHHHHHHCCCCCHHHHHHCCCCHHHHHCCEEEEEEE
DPISYDGQDRYPKALLHGIRWLLYRNGPAASVIVEGGGFFQSEGAKRPDLQIHIAPAMVV
CCCCCCCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCEECCCCCCCCCEEEEEECEEEE
RGGQTRLDGHGFTINSTFLRPRSIGSVEVRSSNPADEPLVDPNYLSDPYDRGMALKSVRI
ECCCEEECCCCEEEECEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCHHHHHHHH
IRDVLAQSEIAKFVKVERLPGPAAKTDEELMAYIRQYACCDYHPVGTCKMGVDETAVVDP
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEECC
ELRVRGVDGLRVIDSSIMPVLISGNTNGPTMMIGEKGADLVKGVQSGRSAQAIAAVA
CEEEECCCCCEEECCCCCEEEEECCCCCCEEEEECCCCHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11390693 [H]