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The map label for this gene is hom [H]

Identifier: 13471060

GI number: 13471060

Start: 751933

End: 753246

Strand: Reverse

Name: hom [H]

Synonym: mll0934

Alternate gene names: 13471060

Gene position: 753246-751933 (Counterclockwise)

Preceding gene: 13471061

Following gene: 13471059

Centisome position: 10.71

GC content: 65.53

Gene sequence:

>1314_bases
ATGGCTGAAGCTCTGCGTGTTGGAATTGCCGGACTTGGCACGGTGGGTGCAGCGGTGGCGCGGGTGCTGCGCGACAAGGC
GGCGGAGCTGACCCGGCAATGCGGGCGCGACATCGTCGTGTCGGCGGTTTCGGCGCGCGACCCGAAACGCGACCGTGGCG
TCGATGTCAGCGCCGCAAAATGGTTCGACGATCCGGTCAAGATGGCGCAGAGCGCCGAGATCGATGTGTTCATCGAACTG
ATCGGCGGCGACGAGGGGCCGGCGCGCCTGTCGGTGAAGGCGGCGCTCGAAGCCGGCCGCCACGTCGTTACCGCCAACAA
GGCGCTGCTTGCCAAGCATGGCGTGGCGCTGGCCGAGATCGCCGAGAAGAAGGGCGTGCTGCTCAACTACGAGGCGGCGG
TGGCGGGCGGCATTCCCGTCATCAAGACGATGCGCGAGGCGATGGCCGGCAACTCGGTCACCCGCGTGTTCGGCATTCTC
AACGGCACCTGCAACTACATCCTGACCCGCATGGAGGCCGAGGGCATCTCGTTCGATGCCTGCCTGAAGGATGCGCAGCG
GCTGGGCTACGCCGAGGCCGATCCGACCTTCGACATCGAGGGCCATGACACCGCGCACAAGCTGTCGATCCTGACCAGCC
TTGCCTTCGGCACCAAGATCGCCGCCAACGACATCTATATGGAAGGCATCTCCAACATCACACAGGCCGACATCCGCGCC
GCCGGCGATCTCGGCTACCGGATCAAGCTGCTCGGCGTTGCCCAGCGCACCGATAGCGGTATCGAGCAGCGCGTGCATCC
GACCATGGTGCCGACCGCCTCCGTTATCGCGCAAGTGCATGGCGTCACCAATGCGGTGGCGATCGAGACCGATATCCTTG
GCGAATTGCTGCTCTCCGGCCCTGGCGCCGGCGGCAACGCCACCGCCTCTGCCGTGATCGGCGACATCGCCGACATAGCC
AAGAGCCGCCCCGGCTTCCAGCATGGTCCGGTCTTTGGCCTGCCGGCGAAGGAGCTCAGGCCCTACAAGAAGGCGCAGAT
GCGCAGCCATGCCGGCGGCTACTTCATCCGGCTAACCGTGCATGATCGCATTGGCGTCTTCGCCGCGATCGCCAAGCGCA
TGGCCGACAACGATATTTCACTGGAATCGATCGTCCAGCACGCAGTCAACGGCGAAGCGGCGGCGCAGAAGACGGTGATC
CTCGTCACCCACGAGACCACCGAGGCCGCCGTGCGCAAGGCCGTCGACGGCATCACCAAGGACGGTCACCTGACCGACAA
GCCGCAGGTCATCCGCATCGAGCGGGCAGGGTAA

Upstream 100 bases:

>100_bases
CGCTTCCTGTCGACCAGCGCCAAGCAGCCCAACAATGTGGTGCCGCTGTCCGCCCACCGGTAAGCAAAATTCGATCTGAT
TTTGAGGGACGTCGCCTTCC

Downstream 100 bases:

>100_bases
CTTCGTCCCCAAGGGGAATCCCGGGATCCCGTCGCGACCAGCCGCGAATAAGCCGGAACGAATTCGTTGCGGCGCCGTTC
TCTTGGTCAGCAACCAAGGG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MAEALRVGIAGLGTVGAAVARVLRDKAAELTRQCGRDIVVSAVSARDPKRDRGVDVSAAKWFDDPVKMAQSAEIDVFIEL
IGGDEGPARLSVKAALEAGRHVVTANKALLAKHGVALAEIAEKKGVLLNYEAAVAGGIPVIKTMREAMAGNSVTRVFGIL
NGTCNYILTRMEAEGISFDACLKDAQRLGYAEADPTFDIEGHDTAHKLSILTSLAFGTKIAANDIYMEGISNITQADIRA
AGDLGYRIKLLGVAQRTDSGIEQRVHPTMVPTASVIAQVHGVTNAVAIETDILGELLLSGPGAGGNATASAVIGDIADIA
KSRPGFQHGPVFGLPAKELRPYKKAQMRSHAGGYFIRLTVHDRIGVFAAIAKRMADNDISLESIVQHAVNGEAAAQKTVI
LVTHETTEAAVRKAVDGITKDGHLTDKPQVIRIERAG

Sequences:

>Translated_437_residues
MAEALRVGIAGLGTVGAAVARVLRDKAAELTRQCGRDIVVSAVSARDPKRDRGVDVSAAKWFDDPVKMAQSAEIDVFIEL
IGGDEGPARLSVKAALEAGRHVVTANKALLAKHGVALAEIAEKKGVLLNYEAAVAGGIPVIKTMREAMAGNSVTRVFGIL
NGTCNYILTRMEAEGISFDACLKDAQRLGYAEADPTFDIEGHDTAHKLSILTSLAFGTKIAANDIYMEGISNITQADIRA
AGDLGYRIKLLGVAQRTDSGIEQRVHPTMVPTASVIAQVHGVTNAVAIETDILGELLLSGPGAGGNATASAVIGDIADIA
KSRPGFQHGPVFGLPAKELRPYKKAQMRSHAGGYFIRLTVHDRIGVFAAIAKRMADNDISLESIVQHAVNGEAAAQKTVI
LVTHETTEAAVRKAVDGITKDGHLTDKPQVIRIERAG
>Mature_436_residues
AEALRVGIAGLGTVGAAVARVLRDKAAELTRQCGRDIVVSAVSARDPKRDRGVDVSAAKWFDDPVKMAQSAEIDVFIELI
GGDEGPARLSVKAALEAGRHVVTANKALLAKHGVALAEIAEKKGVLLNYEAAVAGGIPVIKTMREAMAGNSVTRVFGILN
GTCNYILTRMEAEGISFDACLKDAQRLGYAEADPTFDIEGHDTAHKLSILTSLAFGTKIAANDIYMEGISNITQADIRAA
GDLGYRIKLLGVAQRTDSGIEQRVHPTMVPTASVIAQVHGVTNAVAIETDILGELLLSGPGAGGNATASAVIGDIADIAK
SRPGFQHGPVFGLPAKELRPYKKAQMRSHAGGYFIRLTVHDRIGVFAAIAKRMADNDISLESIVQHAVNGEAAAQKTVIL
VTHETTEAAVRKAVDGITKDGHLTDKPQVIRIERAG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=250, Percent_Identity=29.6, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790376, Length=250, Percent_Identity=26.4, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=122, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46040; Mature: 45909

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEALRVGIAGLGTVGAAVARVLRDKAAELTRQCGRDIVVSAVSARDPKRDRGVDVSAAK
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHCCCCCHHCCCCCHHHH
WFDDPVKMAQSAEIDVFIELIGGDEGPARLSVKAALEAGRHVVTANKALLAKHGVALAEI
HCCHHHHHHCCCCEEEEEEEECCCCCCCEEEHHHHHHCCCEEEECCHHHHHHCCHHHHHH
AEKKGVLLNYEAAVAGGIPVIKTMREAMAGNSVTRVFGILNGTCNYILTRMEAEGISFDA
HHHCCCEEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHEEEHHCCCCCHHH
CLKDAQRLGYAEADPTFDIEGHDTAHKLSILTSLAFGTKIAANDIYMEGISNITQADIRA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHH
AGDLGYRIKLLGVAQRTDSGIEQRVHPTMVPTASVIAQVHGVTNAVAIETDILGELLLSG
CCCCCEEEEEEEEHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHCC
PGAGGNATASAVIGDIADIAKSRPGFQHGPVFGLPAKELRPYKKAQMRSHAGGYFIRLTV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCHHHHHHHHHCCCCEEEEEEE
HDRIGVFAAIAKRMADNDISLESIVQHAVNGEAAAQKTVILVTHETTEAAVRKAVDGITK
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHCCCC
DGHLTDKPQVIRIERAG
CCCCCCCCCEEEEECCC
>Mature Secondary Structure 
AEALRVGIAGLGTVGAAVARVLRDKAAELTRQCGRDIVVSAVSARDPKRDRGVDVSAAK
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHCCCCCHHCCCCCHHHH
WFDDPVKMAQSAEIDVFIELIGGDEGPARLSVKAALEAGRHVVTANKALLAKHGVALAEI
HCCHHHHHHCCCCEEEEEEEECCCCCCCEEEHHHHHHCCCEEEECCHHHHHHCCHHHHHH
AEKKGVLLNYEAAVAGGIPVIKTMREAMAGNSVTRVFGILNGTCNYILTRMEAEGISFDA
HHHCCCEEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHEEEHHCCCCCHHH
CLKDAQRLGYAEADPTFDIEGHDTAHKLSILTSLAFGTKIAANDIYMEGISNITQADIRA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHH
AGDLGYRIKLLGVAQRTDSGIEQRVHPTMVPTASVIAQVHGVTNAVAIETDILGELLLSG
CCCCCEEEEEEEEHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHCC
PGAGGNATASAVIGDIADIAKSRPGFQHGPVFGLPAKELRPYKKAQMRSHAGGYFIRLTV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCHHHHHHHHHCCCCEEEEEEE
HDRIGVFAAIAKRMADNDISLESIVQHAVNGEAAAQKTVILVTHETTEAAVRKAVDGITK
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHCCCC
DGHLTDKPQVIRIERAG
CCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]