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The map label for this gene is sul [H]

Identifier: 13470949

GI number: 13470949

Start: 618020

End: 618871

Strand: Reverse

Name: sul [H]

Synonym: mll0788

Alternate gene names: 13470949

Gene position: 618871-618020 (Counterclockwise)

Preceding gene: 13470952

Following gene: 13470948

Centisome position: 8.8

GC content: 65.73

Gene sequence:

>852_bases
ATGACGGCGAGGCGATGGCAGCTGGCGCATGGACGTCATCTCGACCTTGGCGGCAAGGCCGTGGTCGTCGGCATTCTCAA
CGTCACCCCCGACAGCTTTTCCGACGGCGGCCTGTTCGACGCGCCCGAAGCGGCGCTGGCCCAGGCGCGGCGCATGATCG
GGGAAGGGGCAGGGATCATCGATGTCGGTGGAGAATCGACACGGCCGGGTGCCGCCGCCATCTCGGCCAGCGAGGAACAG
GCGCGTGTCCTGCCGGTGATCGAGGCGCTGGCGCGCTCCGGTGACGTGCTGATTTCGGTCGATACCTATCGTGCCGACAC
CGCGCGGCTGGCCGTGGCTGCCGGCGCGCATATCGTCAACGATGTCTGGGGCCTGCAGCGCGAGCCCGATATCGCGCGGG
TCGCCGCCGAAACCGGAGCCGGGCTCATCATCATGCACACCGGACGGGATCGAAAGAAACTGCCCGACGTGATCGCCGAC
CAGTTTGCTTTCCTGGAAAGATCACTGGAGATCGCCCGCCGCAACGGCATTGCGGACGATCGCATCGTGCTCGATCCCGG
TTTCGGCTTCGCCAAGGAGACGGCTGAGGAAAATCTCGACCTGATGGCGCGGTTTTCCGAGCTCCATGCGCTTGGCTTTC
CGCTGATGGCAGGCACTTCGCGAAAACGCTTCATCGGCACCGTCACTGGCCGCGACGCGGCCGACCGGGCCCCCGGAACG
GCGGCGACCAGCGTCATTCTCAGGCTCAAGGGCGCGCATCTGTTTCGCGTCCACGATGTCGCAATCAACGTGGACGCTCT
GGCCATGGCGGATGCTATGCTGGCGCGTGAAACTGCCGCATCGGAACGCTGA

Upstream 100 bases:

>100_bases
TATTGCCTCTTTACCCACCTTGCTTTACGGCCGTTGCCGGCGCAACGGAATTGATCCTTTGCGGATCACACATCGTTGAT
GAGCCCATGGTTGACGAGCA

Downstream 100 bases:

>100_bases
GCCATGTATGTCATCCGCCTGAAGAACTGCGCCTTCTTTGCCCGGCATGGCGTCCTCGACGAAGAGGAGGCGCTCGGCCA
GCGTTTCTATGTCGATGCAG

Product: dihydroxypteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTARRWQLAHGRHLDLGGKAVVVGILNVTPDSFSDGGLFDAPEAALAQARRMIGEGAGIIDVGGESTRPGAAAISASEEQ
ARVLPVIEALARSGDVLISVDTYRADTARLAVAAGAHIVNDVWGLQREPDIARVAAETGAGLIIMHTGRDRKKLPDVIAD
QFAFLERSLEIARRNGIADDRIVLDPGFGFAKETAEENLDLMARFSELHALGFPLMAGTSRKRFIGTVTGRDAADRAPGT
AATSVILRLKGAHLFRVHDVAINVDALAMADAMLARETAASER

Sequences:

>Translated_283_residues
MTARRWQLAHGRHLDLGGKAVVVGILNVTPDSFSDGGLFDAPEAALAQARRMIGEGAGIIDVGGESTRPGAAAISASEEQ
ARVLPVIEALARSGDVLISVDTYRADTARLAVAAGAHIVNDVWGLQREPDIARVAAETGAGLIIMHTGRDRKKLPDVIAD
QFAFLERSLEIARRNGIADDRIVLDPGFGFAKETAEENLDLMARFSELHALGFPLMAGTSRKRFIGTVTGRDAADRAPGT
AATSVILRLKGAHLFRVHDVAINVDALAMADAMLARETAASER
>Mature_282_residues
TARRWQLAHGRHLDLGGKAVVVGILNVTPDSFSDGGLFDAPEAALAQARRMIGEGAGIIDVGGESTRPGAAAISASEEQA
RVLPVIEALARSGDVLISVDTYRADTARLAVAAGAHIVNDVWGLQREPDIARVAAETGAGLIIMHTGRDRKKLPDVIADQ
FAFLERSLEIARRNGIADDRIVLDPGFGFAKETAEENLDLMARFSELHALGFPLMAGTSRKRFIGTVTGRDAADRAPGTA
ATSVILRLKGAHLFRVHDVAINVDALAMADAMLARETAASER

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=43.7956204379562, Blast_Score=213, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324073, Length=315, Percent_Identity=30.4761904761905, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30019; Mature: 29887

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARRWQLAHGRHLDLGGKAVVVGILNVTPDSFSDGGLFDAPEAALAQARRMIGEGAGII
CCCCCEECCCCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
DVGGESTRPGAAAISASEEQARVLPVIEALARSGDVLISVDTYRADTARLAVAAGAHIVN
EECCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCHHHHH
DVWGLQREPDIARVAAETGAGLIIMHTGRDRKKLPDVIADQFAFLERSLEIARRNGIADD
HHHCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RIVLDPGFGFAKETAEENLDLMARFSELHALGFPLMAGTSRKRFIGTVTGRDAADRAPGT
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCH
AATSVILRLKGAHLFRVHDVAINVDALAMADAMLARETAASER
HHHHHHHHCCCCEEEEEEEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TARRWQLAHGRHLDLGGKAVVVGILNVTPDSFSDGGLFDAPEAALAQARRMIGEGAGII
CCCCEECCCCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
DVGGESTRPGAAAISASEEQARVLPVIEALARSGDVLISVDTYRADTARLAVAAGAHIVN
EECCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCHHHHH
DVWGLQREPDIARVAAETGAGLIIMHTGRDRKKLPDVIADQFAFLERSLEIARRNGIADD
HHHCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RIVLDPGFGFAKETAEENLDLMARFSELHALGFPLMAGTSRKRFIGTVTGRDAADRAPGT
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCH
AATSVILRLKGAHLFRVHDVAINVDALAMADAMLARETAASER
HHHHHHHHCCCCEEEEEEEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]