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The map label for this gene is kefBC [H]

Identifier: 13470945

GI number: 13470945

Start: 614761

End: 616596

Strand: Direct

Name: kefBC [H]

Synonym: mlr0783

Alternate gene names: 13470945

Gene position: 614761-616596 (Clockwise)

Preceding gene: 13470941

Following gene: 13470946

Centisome position: 8.74

GC content: 64.92

Gene sequence:

>1836_bases
ATGGCAGCGGAAACATCAGGCAGCGATCTCATTCAGGTGGTGGCGCTGCTTGCCGCTGGGGTCGTCGCCGTCCCCATCTT
CAAGCGCATGGGCCTCGGCTCGATCCTGGGCTATCTGGCCGCCGGCGTGGTGATCGGCCCGTTTGGCCTTCGCATCTTTT
CCGAATCGGGAGCCATCCTCCACGTCGCCGAGCTCGGCGTCGTCATGTTCCTGTTCATCATCGGGCTGGAAATGCAGCCG
TCGCGGCTTTGGGGCCTACGCCGCGAAATCTTCGGGCTCGGTGCGCTGCAGGTCGGGGTCTGCGCGGTTCTGTTGACCGG
CGTGGGAATGGCCGGCGGTTTTCCAGTCTCGCAATCCTTTGTCGCCGGGGCCGGTTTCGTGCTGACCTCGACGGCGATCG
TCATGCAGCTTCTCGAGGAACGTGGCGAAATCGCCTCGCCGAAAGGCCAGCGCATCGTCTCCATCTTGCTGCTGGAAGAT
CTGGCCATCGTGCCGCTGCTGGCCCTGATCGCGTTCCTGGCGCCCGGTGGTGCCGACACCAGCATGTCGGAGCGGTTGAC
CGAGGTCGGCATCGGCCTTGCCGCGATCGTCGGGCTGGTGCTGGCGGGCCGCTATCTGCTCAACCCCTTCTTCCGCATCC
TGGCGGATGCCCGAGCCCGCGAGGTGATGACGGCCGCGGCATTGCTGGTCGTGCTCGGATCGGCGCTCGCCATGCAGCTC
AGCGGGCTGTCGATGGCGATGGGCGCGTTCCTGGCCGGCGTGCTTCTGTCCGAATCGACCTTCCGCCATCAGCTGGAAGC
CGACATCGAGCCGTTCCGCGGCATCTTGCTCGGCCTGTTCTTCCTGGCGGTCGGCATGTCGCTCGACCTGCATGTGGTGG
CCGCGAACTGGAGGCTGATCGCTGTCTATGTCGTCGCCTACATGGTCATGAAGGCTCTTGGCATCTACATCGTCGCCCGC
ATCCTCAAGACCGGCCATCGCGAAGCGCTGGAACGCGCCGTCTTCATGGCGCAGGGCGGCGAATTCGCCTTCGTCCTCTA
CTCCGCTGCCGCTGCCGTCGGCATCATCGACAACCAGGCCAACGCGACGCTGACGGCGATCGTCATCATTTCCATGGTGC
TGACGCCACTGGCGATCATCGCCTTGCGCTATGTCACCCCGCGCGACGAGCAGTCGCTCGACGGGGTCGATGTCGCCGAC
GGCCTGACCGGCAGCGTGTTGATCATCGGTTTCGGCCGCTTCGGCCAGATCGCCAGCCAACCACTGCTGCTGCGCGGCAT
CGATGTGTCGATCATCGACAATGATGTCGAGATGATCCAGGCGGCGGCCGATTTCGGCTTCAAGGTCTATTATGGTGATG
GCACGCGGCTGGATATCCTGCACGCGGCCGGAGCCGGCCGGGCGCGCGCCGTGCTGATCTGCGTCGACAAGGCCGATGCG
GCCGTCCGTATTGTCCAGTTGATCAAGGCGGAATTTCCGCTGCTCACCGTGCTGGCCCGGGCTTTCGACCGCGGCACGGC
GCTGCAGCTCATCCGCGCCGGCGTCGACTATCAGTTGCGCGAGACTTTCGAATCGGCACTGGTTTTCGGCGGCTCGGCCC
TGGAATCGCTCGGCGTTGATCCCGAAGATGTGGCCGAGACGATCGAGGACGTCAGGCGCCGCGACACCGAACGTTTCGAA
ACCCAGCTCGCGGAAGGCATTCGCGCAGGCCAGCGCTTCCTGCGGGGCAATATCGGCACGCCGATTCCGACACCGCTCTC
CACGCCGCGCCGTCCTGGTCAGGCCCTCAACGAGGAGACGGCCGGCGTTCTGCACAAATCCGAAACAGCCGACTGA

Upstream 100 bases:

>100_bases
CGGCATCCTCCCCGTCCTGGCAGGCTCCCCGCCCTTGCCTCCCGCTCCAACTGCATGCAAGGAGTGCTGTCGGACATAGG
GAGACACAGGGACAAGAGGC

Downstream 100 bases:

>100_bases
ACCAAGGAACCATGCATGGAACTGGACAGCGGAGCCCTGTCGGTCACCAAATTCTGGCGCGACGCCGGCGAGGATGCATG
GTTCGAGAAGAACGACGCTT

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MAAETSGSDLIQVVALLAAGVVAVPIFKRMGLGSILGYLAAGVVIGPFGLRIFSESGAILHVAELGVVMFLFIIGLEMQP
SRLWGLRREIFGLGALQVGVCAVLLTGVGMAGGFPVSQSFVAGAGFVLTSTAIVMQLLEERGEIASPKGQRIVSILLLED
LAIVPLLALIAFLAPGGADTSMSERLTEVGIGLAAIVGLVLAGRYLLNPFFRILADARAREVMTAAALLVVLGSALAMQL
SGLSMAMGAFLAGVLLSESTFRHQLEADIEPFRGILLGLFFLAVGMSLDLHVVAANWRLIAVYVVAYMVMKALGIYIVAR
ILKTGHREALERAVFMAQGGEFAFVLYSAAAAVGIIDNQANATLTAIVIISMVLTPLAIIALRYVTPRDEQSLDGVDVAD
GLTGSVLIIGFGRFGQIASQPLLLRGIDVSIIDNDVEMIQAAADFGFKVYYGDGTRLDILHAAGAGRARAVLICVDKADA
AVRIVQLIKAEFPLLTVLARAFDRGTALQLIRAGVDYQLRETFESALVFGGSALESLGVDPEDVAETIEDVRRRDTERFE
TQLAEGIRAGQRFLRGNIGTPIPTPLSTPRRPGQALNEETAGVLHKSETAD

Sequences:

>Translated_611_residues
MAAETSGSDLIQVVALLAAGVVAVPIFKRMGLGSILGYLAAGVVIGPFGLRIFSESGAILHVAELGVVMFLFIIGLEMQP
SRLWGLRREIFGLGALQVGVCAVLLTGVGMAGGFPVSQSFVAGAGFVLTSTAIVMQLLEERGEIASPKGQRIVSILLLED
LAIVPLLALIAFLAPGGADTSMSERLTEVGIGLAAIVGLVLAGRYLLNPFFRILADARAREVMTAAALLVVLGSALAMQL
SGLSMAMGAFLAGVLLSESTFRHQLEADIEPFRGILLGLFFLAVGMSLDLHVVAANWRLIAVYVVAYMVMKALGIYIVAR
ILKTGHREALERAVFMAQGGEFAFVLYSAAAAVGIIDNQANATLTAIVIISMVLTPLAIIALRYVTPRDEQSLDGVDVAD
GLTGSVLIIGFGRFGQIASQPLLLRGIDVSIIDNDVEMIQAAADFGFKVYYGDGTRLDILHAAGAGRARAVLICVDKADA
AVRIVQLIKAEFPLLTVLARAFDRGTALQLIRAGVDYQLRETFESALVFGGSALESLGVDPEDVAETIEDVRRRDTERFE
TQLAEGIRAGQRFLRGNIGTPIPTPLSTPRRPGQALNEETAGVLHKSETAD
>Mature_610_residues
AAETSGSDLIQVVALLAAGVVAVPIFKRMGLGSILGYLAAGVVIGPFGLRIFSESGAILHVAELGVVMFLFIIGLEMQPS
RLWGLRREIFGLGALQVGVCAVLLTGVGMAGGFPVSQSFVAGAGFVLTSTAIVMQLLEERGEIASPKGQRIVSILLLEDL
AIVPLLALIAFLAPGGADTSMSERLTEVGIGLAAIVGLVLAGRYLLNPFFRILADARAREVMTAAALLVVLGSALAMQLS
GLSMAMGAFLAGVLLSESTFRHQLEADIEPFRGILLGLFFLAVGMSLDLHVVAANWRLIAVYVVAYMVMKALGIYIVARI
LKTGHREALERAVFMAQGGEFAFVLYSAAAAVGIIDNQANATLTAIVIISMVLTPLAIIALRYVTPRDEQSLDGVDVADG
LTGSVLIIGFGRFGQIASQPLLLRGIDVSIIDNDVEMIQAAADFGFKVYYGDGTRLDILHAAGAGRARAVLICVDKADAA
VRIVQLIKAEFPLLTVLARAFDRGTALQLIRAGVDYQLRETFESALVFGGSALESLGVDPEDVAETIEDVRRRDTERFET
QLAEGIRAGQRFLRGNIGTPIPTPLSTPRRPGQALNEETAGVLHKSETAD

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=394, Percent_Identity=26.1421319796954, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1786232, Length=552, Percent_Identity=41.1231884057971, Blast_Score=407, Evalue=1e-114,
Organism=Escherichia coli, GI1789749, Length=557, Percent_Identity=42.5493716337522, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1786685, Length=496, Percent_Identity=25.6048387096774, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 64640; Mature: 64509

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAETSGSDLIQVVALLAAGVVAVPIFKRMGLGSILGYLAAGVVIGPFGLRIFSESGAIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHEEECCCCCEE
HVAELGVVMFLFIIGLEMQPSRLWGLRREIFGLGALQVGVCAVLLTGVGMAGGFPVSQSF
EHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHH
VAGAGFVLTSTAIVMQLLEERGEIASPKGQRIVSILLLEDLAIVPLLALIAFLAPGGADT
HHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SMSERLTEVGIGLAAIVGLVLAGRYLLNPFFRILADARAREVMTAAALLVVLGSALAMQL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLSMAMGAFLAGVLLSESTFRHQLEADIEPFRGILLGLFFLAVGMSLDLHVVAANWRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHH
AVYVVAYMVMKALGIYIVARILKTGHREALERAVFMAQGGEFAFVLYSAAAAVGIIDNQA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHEECCCC
NATLTAIVIISMVLTPLAIIALRYVTPRDEQSLDGVDVADGLTGSVLIIGFGRFGQIASQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHCC
PLLLRGIDVSIIDNDVEMIQAAADFGFKVYYGDGTRLDILHAAGAGRARAVLICVDKADA
CEEEECCEEEEECCHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCCCEEEEEEECCCHH
AVRIVQLIKAEFPLLTVLARAFDRGTALQLIRAGVDYQLRETFESALVFGGSALESLGVD
HHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHCCCC
PEDVAETIEDVRRRDTERFETQLAEGIRAGQRFLRGNIGTPIPTPLSTPRRPGQALNEET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCHHH
AGVLHKSETAD
HHHHCCCCCCC
>Mature Secondary Structure 
AAETSGSDLIQVVALLAAGVVAVPIFKRMGLGSILGYLAAGVVIGPFGLRIFSESGAIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHEEECCCCCEE
HVAELGVVMFLFIIGLEMQPSRLWGLRREIFGLGALQVGVCAVLLTGVGMAGGFPVSQSF
EHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHH
VAGAGFVLTSTAIVMQLLEERGEIASPKGQRIVSILLLEDLAIVPLLALIAFLAPGGADT
HHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SMSERLTEVGIGLAAIVGLVLAGRYLLNPFFRILADARAREVMTAAALLVVLGSALAMQL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLSMAMGAFLAGVLLSESTFRHQLEADIEPFRGILLGLFFLAVGMSLDLHVVAANWRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHH
AVYVVAYMVMKALGIYIVARILKTGHREALERAVFMAQGGEFAFVLYSAAAAVGIIDNQA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHEECCCC
NATLTAIVIISMVLTPLAIIALRYVTPRDEQSLDGVDVADGLTGSVLIIGFGRFGQIASQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHCC
PLLLRGIDVSIIDNDVEMIQAAADFGFKVYYGDGTRLDILHAAGAGRARAVLICVDKADA
CEEEECCEEEEECCHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCCCEEEEEEECCCHH
AVRIVQLIKAEFPLLTVLARAFDRGTALQLIRAGVDYQLRETFESALVFGGSALESLGVD
HHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHCCCC
PEDVAETIEDVRRRDTERFETQLAEGIRAGQRFLRGNIGTPIPTPLSTPRRPGQALNEET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCHHH
AGVLHKSETAD
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]