Click here to switch to the map view.

The map label for this gene is ppiD [H]

Identifier: 13470813

GI number: 13470813

Start: 477579

End: 479471

Strand: Direct

Name: ppiD [H]

Synonym: mlr0613

Alternate gene names: 13470813

Gene position: 477579-479471 (Clockwise)

Preceding gene: 13470812

Following gene: 13470814

Centisome position: 6.79

GC content: 63.23

Gene sequence:

>1893_bases
ATGCTTGGTATATTGAGAAGCGCGGCGGGTACATGGGTCGCGAAGACATTGCTGTCGCTGCTGGTGGTCAGTTTCGCCGC
CTGGGGCATCTCCGGTCGGCTGATGGGCGGCTTTGCCGGCCACGATTCGGTGATAATAGCGGGCGGCACCAAGGTATCGA
TCAACGAATACCGCCTCGCCTATGATCGCCAGCTCGCCGTCATGTCGCAGCAGTTCGGTCAGCGCCTCACCCACGAACAG
GCAAAGGCGCTCGGCATCGACAACCAGGTTCTGGCTCAGCTTGTCTCCGGCGCCGTTCTCGACGAACAGGCTCGCAAGCT
TGGGCTCGGCCTGTCCAAGGACCGGCTGGCCGAGCTGACGCGCGAGGACCCGGCGTTCAAGGGCCCAGGCGGCGAGTTCG
ACAGGAGAACATTCGAATACATGCTGCGCCAGGTCGGCATGCGGCCCGAAGATTACCTGAAGAACCGCGCCCAGGTGGCG
GTGCGCCAGCAGATCGTCGAGGCGGTCTCGGACGGCCTCAAGGCGCCGGACGCTTTCTTCAAGGCGGTCGCGCTCTATCG
CGGCGAGGACCGCACCGTTGACTACCTGCTGTTGCCGAAGAAGCTCGTCGAGCCCATCGAAGCACCGAGCGACAGCGTGC
TTCAGGCCTATTTCGAGGCCAACAAGAAAACCTACGCGGCACCTGAGTACCGCAAATTCTCCTATGTCCGCCTCGAGCCG
GTGGACATCATGGATCCGACCGCCGTCACCGAGCAACAGGTCAGCGACGACTACAACAAGAACAAGACGCGCTACACCAC
GCCCGAAATGCGCACGATCGAGCAGCTTGTGTTCAAGACACCGGATGCGGCCAAGGCCGCACTCGATTCGCTCAAGGCCG
GCGCCACCTTCGAAAAGCTTGTGACAGCCGAAGGCAAGACCCCGGCCGACACGCTGCTTGGCACGTTGGCCAAGGACAAG
ATCGCCGACAAGGCGGTTGCCGATGCCGCCTTTGCGCTCAACGCCAATGAAGTCAGCCAGGTCGTTCAGGGCGCCTTCGG
CCCGGTGCTGCTGCGCGTCACCGAGATCAAACCCGAGGTGGTGAAGCCGCTCGCCGAAGTGTCCGACCAGATCCGCAAGG
ACCTGGCGTTGGGCGAGGCAAGCCGCATCCTTTTGGATGTGCACGACAATTACGAAGACACCCGCGCCTCCGGCAGTTCG
CTGGCCGACGCGGCTGCCAAGCTGAAGCTGAAGGACGTCACCATCGACGCCATCGACCGCAGCGGCCTCAGGCCGGACGG
CTCCATCGTCAAGGACCTGCCGGAATCGCCGGCGCTGATCAAGGCGGTCTTTGATGCCGAACCCAAAACCGAAAACGAAG
CGCTGACCACGGCCGACAACGGCTTCATCTTCTATGAGGTTGCTTCGATCACGCCGGCTCGCGACCGGACGCTGGACGAG
GTCCGCCAGAAAGTCGTCGCCGACTGGACTGCTGCTGAGACCACCAAGCGGCTTGCCGCCAAGGCAAGCGAGCTCGACAA
GCGGCTCAAGGCAGGCGCCACGCTCGATGTCATCGCCGGTGATCTCAAGCTGGAGAAGCAGACCAAGCGCGGCCTGAAGC
GCGAGGCCGACGATGCCGATTTCGGCAAGGAGGGTGCTGCCGTGATGTTCGGCGTCGGCGAAGGCGGCACCGGTTTGATC
CCCTCGCCCACCGGTGACGGACAGATCCTGTTCAAGGTCGCCGAAGTGTTCGAGCCCGCCGGAGCCGATGCCAGCTCGGT
GCCGGAAGACGCGCAGAAATCCTTCACTTCCGGCATGTCGGACGATCTGCTCGACCAATTGGTGGCGCAGTTGCAGACGC
AGTACGACGTCCGCATCGACCAGGCCGCCGTTGCCCAAGCCGCGACAAGATGA

Upstream 100 bases:

>100_bases
AAAATCAGGCCACAAAGCAATCGACAGTAGGCCGGAAGGGCGCTATTGCGCTTGTTTCAGACTCGGCGCACGCGAAAATG
CGCATAAATCGGAAGTAACG

Downstream 100 bases:

>100_bases
GCGCGTTGAAAACCCATATCGCCAAGGTGGCGGCCGGCACCGCGCTTTCCTTCGAGGAAGCGCGCGAGGCCTTCGACATA
ATCATGTCGGGCGACGCGAC

Product: peptidyl-prolyl cis-trans isomerse D

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MLGILRSAAGTWVAKTLLSLLVVSFAAWGISGRLMGGFAGHDSVIIAGGTKVSINEYRLAYDRQLAVMSQQFGQRLTHEQ
AKALGIDNQVLAQLVSGAVLDEQARKLGLGLSKDRLAELTREDPAFKGPGGEFDRRTFEYMLRQVGMRPEDYLKNRAQVA
VRQQIVEAVSDGLKAPDAFFKAVALYRGEDRTVDYLLLPKKLVEPIEAPSDSVLQAYFEANKKTYAAPEYRKFSYVRLEP
VDIMDPTAVTEQQVSDDYNKNKTRYTTPEMRTIEQLVFKTPDAAKAALDSLKAGATFEKLVTAEGKTPADTLLGTLAKDK
IADKAVADAAFALNANEVSQVVQGAFGPVLLRVTEIKPEVVKPLAEVSDQIRKDLALGEASRILLDVHDNYEDTRASGSS
LADAAAKLKLKDVTIDAIDRSGLRPDGSIVKDLPESPALIKAVFDAEPKTENEALTTADNGFIFYEVASITPARDRTLDE
VRQKVVADWTAAETTKRLAAKASELDKRLKAGATLDVIAGDLKLEKQTKRGLKREADDADFGKEGAAVMFGVGEGGTGLI
PSPTGDGQILFKVAEVFEPAGADASSVPEDAQKSFTSGMSDDLLDQLVAQLQTQYDVRIDQAAVAQAATR

Sequences:

>Translated_630_residues
MLGILRSAAGTWVAKTLLSLLVVSFAAWGISGRLMGGFAGHDSVIIAGGTKVSINEYRLAYDRQLAVMSQQFGQRLTHEQ
AKALGIDNQVLAQLVSGAVLDEQARKLGLGLSKDRLAELTREDPAFKGPGGEFDRRTFEYMLRQVGMRPEDYLKNRAQVA
VRQQIVEAVSDGLKAPDAFFKAVALYRGEDRTVDYLLLPKKLVEPIEAPSDSVLQAYFEANKKTYAAPEYRKFSYVRLEP
VDIMDPTAVTEQQVSDDYNKNKTRYTTPEMRTIEQLVFKTPDAAKAALDSLKAGATFEKLVTAEGKTPADTLLGTLAKDK
IADKAVADAAFALNANEVSQVVQGAFGPVLLRVTEIKPEVVKPLAEVSDQIRKDLALGEASRILLDVHDNYEDTRASGSS
LADAAAKLKLKDVTIDAIDRSGLRPDGSIVKDLPESPALIKAVFDAEPKTENEALTTADNGFIFYEVASITPARDRTLDE
VRQKVVADWTAAETTKRLAAKASELDKRLKAGATLDVIAGDLKLEKQTKRGLKREADDADFGKEGAAVMFGVGEGGTGLI
PSPTGDGQILFKVAEVFEPAGADASSVPEDAQKSFTSGMSDDLLDQLVAQLQTQYDVRIDQAAVAQAATR
>Mature_630_residues
MLGILRSAAGTWVAKTLLSLLVVSFAAWGISGRLMGGFAGHDSVIIAGGTKVSINEYRLAYDRQLAVMSQQFGQRLTHEQ
AKALGIDNQVLAQLVSGAVLDEQARKLGLGLSKDRLAELTREDPAFKGPGGEFDRRTFEYMLRQVGMRPEDYLKNRAQVA
VRQQIVEAVSDGLKAPDAFFKAVALYRGEDRTVDYLLLPKKLVEPIEAPSDSVLQAYFEANKKTYAAPEYRKFSYVRLEP
VDIMDPTAVTEQQVSDDYNKNKTRYTTPEMRTIEQLVFKTPDAAKAALDSLKAGATFEKLVTAEGKTPADTLLGTLAKDK
IADKAVADAAFALNANEVSQVVQGAFGPVLLRVTEIKPEVVKPLAEVSDQIRKDLALGEASRILLDVHDNYEDTRASGSS
LADAAAKLKLKDVTIDAIDRSGLRPDGSIVKDLPESPALIKAVFDAEPKTENEALTTADNGFIFYEVASITPARDRTLDE
VRQKVVADWTAAETTKRLAAKASELDKRLKAGATLDVIAGDLKLEKQTKRGLKREADDADFGKEGAAVMFGVGEGGTGLI
PSPTGDGQILFKVAEVFEPAGADASSVPEDAQKSFTSGMSDDLLDQLVAQLQTQYDVRIDQAAVAQAATR

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=385, Percent_Identity=26.7532467532467, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 68161; Mature: 68161

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGILRSAAGTWVAKTLLSLLVVSFAAWGISGRLMGGFAGHDSVIIAGGTKVSINEYRLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEECCCEEEHHHHHHH
YDRQLAVMSQQFGQRLTHEQAKALGIDNQVLAQLVSGAVLDEQARKLGLGLSKDRLAELT
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHH
REDPAFKGPGGEFDRRTFEYMLRQVGMRPEDYLKNRAQVAVRQQIVEAVSDGLKAPDAFF
HCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KAVALYRGEDRTVDYLLLPKKLVEPIEAPSDSVLQAYFEANKKTYAAPEYRKFSYVRLEP
HHHHHHCCCCCCEEEEECCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
VDIMDPTAVTEQQVSDDYNKNKTRYTTPEMRTIEQLVFKTPDAAKAALDSLKAGATFEKL
CCCCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHH
VTAEGKTPADTLLGTLAKDKIADKAVADAAFALNANEVSQVVQGAFGPVLLRVTEIKPEV
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCHHH
VKPLAEVSDQIRKDLALGEASRILLDVHDNYEDTRASGSSLADAAAKLKLKDVTIDAIDR
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCHHHHHHHHEEEEEEEEEHHHC
SGLRPDGSIVKDLPESPALIKAVFDAEPKTENEALTTADNGFIFYEVASITPARDRTLDE
CCCCCCCHHHHHCCCCCHHHHHHHCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCHHHH
VRQKVVADWTAAETTKRLAAKASELDKRLKAGATLDVIAGDLKLEKQTKRGLKREADDAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHCHHCCCCCCC
FGKEGAAVMFGVGEGGTGLIPSPTGDGQILFKVAEVFEPAGADASSVPEDAQKSFTSGMS
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCC
DDLLDQLVAQLQTQYDVRIDQAAVAQAATR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLGILRSAAGTWVAKTLLSLLVVSFAAWGISGRLMGGFAGHDSVIIAGGTKVSINEYRLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEECCCEEEHHHHHHH
YDRQLAVMSQQFGQRLTHEQAKALGIDNQVLAQLVSGAVLDEQARKLGLGLSKDRLAELT
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHH
REDPAFKGPGGEFDRRTFEYMLRQVGMRPEDYLKNRAQVAVRQQIVEAVSDGLKAPDAFF
HCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KAVALYRGEDRTVDYLLLPKKLVEPIEAPSDSVLQAYFEANKKTYAAPEYRKFSYVRLEP
HHHHHHCCCCCCEEEEECCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
VDIMDPTAVTEQQVSDDYNKNKTRYTTPEMRTIEQLVFKTPDAAKAALDSLKAGATFEKL
CCCCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHH
VTAEGKTPADTLLGTLAKDKIADKAVADAAFALNANEVSQVVQGAFGPVLLRVTEIKPEV
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCHHH
VKPLAEVSDQIRKDLALGEASRILLDVHDNYEDTRASGSSLADAAAKLKLKDVTIDAIDR
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCHHHHHHHHEEEEEEEEEHHHC
SGLRPDGSIVKDLPESPALIKAVFDAEPKTENEALTTADNGFIFYEVASITPARDRTLDE
CCCCCCCHHHHHCCCCCHHHHHHHCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCHHHH
VRQKVVADWTAAETTKRLAAKASELDKRLKAGATLDVIAGDLKLEKQTKRGLKREADDAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHCHHCCCCCCC
FGKEGAAVMFGVGEGGTGLIPSPTGDGQILFKVAEVFEPAGADASSVPEDAQKSFTSGMS
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCC
DDLLDQLVAQLQTQYDVRIDQAAVAQAATR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]