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The map label for this gene is slt [H]

Identifier: 15602191

GI number: 15602191

Start: 380277

End: 382319

Strand: Reverse

Name: slt [H]

Synonym: PM0326

Alternate gene names: 15602191

Gene position: 382319-380277 (Counterclockwise)

Preceding gene: 161723316

Following gene: 15602190

Centisome position: 16.94

GC content: 42.68

Gene sequence:

>2043_bases
ATGAAACTAACAAAAATTGCGCTCACTTATTTACTGACCTTGATGTCGATGTCACTTGCTGCCGTGTCTGTTAGCGTACC
AGAAGATAAGACTCAACCTACTGAGGCATCGCTTACCACGACCAATTTAGTGCAAGCACGCCAGATTTATCAAAAAATAC
ATCAATTACTGCAACGTTCACAATCCGAAAACACGCAACGGATTGTGCAAGCCCTATTAGCAAAAATTGAGGATTATCCT
CTTTATCCTTACGCTCAATACGCTTACTTAAAAGCACTCAAAGACCAATTATCCTTAGCACAAATTGAGGCATTCCAAAC
CGATTTTCCGTCTTTTCCCTTAACAACGGAATTGCAAAAACAATGGTTACAACAGGCTCAAGACAAGGCTGAATGGCAAG
CGATTATTCACTCCCCTTTCCGCCCTAAAGATATGGCTTCACGTTGCATACAGTTACAAGCGGAATATGAAACGCAGCCT
AATTCTCCAGCGTTTTCCCTCAAACAATGGCAACAACAAGTCGCCCAAATATGGCGCAATGGTGCTTCTTTACCGAAAGC
CTGTGATACGCTTTTCGCACGTTGGAAAGAAAAAGGTTATCCTGAGGAAACTGAATTAAAAGAACGTGCCGTCCTCGCCT
TTGAGCAAGGCAATCAAGCGCTACTTGCTTCCTTATCACAACAAGCTGACCAAGCAGACACGAAACGCTGGCTAAATGAG
CTCCACCAGCTCAGTAAAAATCCGTTACGCTTACAACACCCTCAATCTGCTTTTTTTATTGATACCCTTTCTGCGGATGA
TCCGTTTGCACAGCGAATCCTGTTAAGTCATTTTTCTACGTTGATAAAACGGCTGAAAGAAACGGACATCAAAAACCAGC
ATGATCCTTTTGAACCCTATGCACAATGGGCAAATAAACTAAGGTTATCTGAAGCACAACAACGTCAATGGAAAAAGCAC
TTAATTAGCCATCTCTTTGATAGTGAAAACCTCAACTTGCAAAAATGGCGAGATGCACAGTTATTTGAGCTGAAAGAAGA
TACGCTCACAGAACGCCGTTTACGTACCGCGCTGCGTGAAAAAACCGAGCTCACACCTTGGCTAGATTTGTTGTCCAATA
GCGCCAAACAGAAAGAAGAATGGCGTTTTTGGCAAGCAAAAGTCTTCGCACAAAATAAAAAAACCACTGAACAAGCCCAA
CAAATCTTTCAACAATTAGCAAAACAACGCGGGTTTTACCCTTTGTTAGCCAGTGCGGAACTGAATATCGACTACGCTCC
CGCAATGGACGTTTTTAGCTCGACTTCTGCCACGGATATACACGAGAAATTCTCCGTTGAATTAAGTAGGATCGCGGAAC
TGCGCGAACACAACGCCACTCAATATATGAATCTTGAGTGGAAAGCCTTATTGGAGAAAGCGAACTTTGAACAAAAACTC
GCCTTGTCACAATTTGCCACGGAACAAGCTTGGTTTGATTTAGGCGTAGAAGCGACAATTCAAGCCAAAGCATGGGGCTA
TCTTGCCCTGCGCTTACCCAATGCCTATTTAGATTGGTTCGATTTACATCTCAATAATAAAAATGTTTCGCGCACTTTTG
CGATGGCTATCGCGCGCCAAGAAAGTGCTTGGAAACCCTATGTTTCCTCTCATGCCAATGCACAAGGGCTGATGCAACTC
TTACCGAGTACCGCAAAACAAACAGCCCAAGAAGCAGGTTTGCCTTATACGCATCAAAAGCAACTGTTTGATCCCTTTGA
TAACATTATGCTAGGCACCGCTCATTTGCAGCAACTGTATGATAAATATGGTAATAACCGTATTTTAATTGCGGCGGCTT
ATAATGCGGGGGCAAGCCGAGTGGATCGTTGGTTAGCGAAAGCGGACGGTAAATTAAGTATGGCAGAATTCATTGCCTCG
ATACCTTTTTATGAAACAAGAGGTTATGTACAAAATGTGTTGACTTATGATGTGTATTATCAGTGGCTACAACAGCAACC
ACAGCAAAAATTTAGCCAAGATGAATATAATCGATTATACTAG

Upstream 100 bases:

>100_bases
CTTTTTCTTGTTCAAAATAAATTAAAAACACACCGCACTTTTCCTGTCAAATCAGGTCTAAATTTGTATCATTTTTATCC
TTAATCTGTTCGAGAAATGA

Downstream 100 bases:

>100_bases
TGCGATAGTCAAAGGGAGGAAATACTATGTACTTAAGTCGCAATCTTGAACAATGGCATGCTTTCGTCGAAATGTTACGC
ACCGCATTCGCCCAAGGCAA

Product: hypothetical protein

Products: 1,6-Anhydrobond [C]

Alternate protein names: Peptidoglycan lytic exotransglycosylase [H]

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MKLTKIALTYLLTLMSMSLAAVSVSVPEDKTQPTEASLTTTNLVQARQIYQKIHQLLQRSQSENTQRIVQALLAKIEDYP
LYPYAQYAYLKALKDQLSLAQIEAFQTDFPSFPLTTELQKQWLQQAQDKAEWQAIIHSPFRPKDMASRCIQLQAEYETQP
NSPAFSLKQWQQQVAQIWRNGASLPKACDTLFARWKEKGYPEETELKERAVLAFEQGNQALLASLSQQADQADTKRWLNE
LHQLSKNPLRLQHPQSAFFIDTLSADDPFAQRILLSHFSTLIKRLKETDIKNQHDPFEPYAQWANKLRLSEAQQRQWKKH
LISHLFDSENLNLQKWRDAQLFELKEDTLTERRLRTALREKTELTPWLDLLSNSAKQKEEWRFWQAKVFAQNKKTTEQAQ
QIFQQLAKQRGFYPLLASAELNIDYAPAMDVFSSTSATDIHEKFSVELSRIAELREHNATQYMNLEWKALLEKANFEQKL
ALSQFATEQAWFDLGVEATIQAKAWGYLALRLPNAYLDWFDLHLNNKNVSRTFAMAIARQESAWKPYVSSHANAQGLMQL
LPSTAKQTAQEAGLPYTHQKQLFDPFDNIMLGTAHLQQLYDKYGNNRILIAAAYNAGASRVDRWLAKADGKLSMAEFIAS
IPFYETRGYVQNVLTYDVYYQWLQQQPQQKFSQDEYNRLY

Sequences:

>Translated_680_residues
MKLTKIALTYLLTLMSMSLAAVSVSVPEDKTQPTEASLTTTNLVQARQIYQKIHQLLQRSQSENTQRIVQALLAKIEDYP
LYPYAQYAYLKALKDQLSLAQIEAFQTDFPSFPLTTELQKQWLQQAQDKAEWQAIIHSPFRPKDMASRCIQLQAEYETQP
NSPAFSLKQWQQQVAQIWRNGASLPKACDTLFARWKEKGYPEETELKERAVLAFEQGNQALLASLSQQADQADTKRWLNE
LHQLSKNPLRLQHPQSAFFIDTLSADDPFAQRILLSHFSTLIKRLKETDIKNQHDPFEPYAQWANKLRLSEAQQRQWKKH
LISHLFDSENLNLQKWRDAQLFELKEDTLTERRLRTALREKTELTPWLDLLSNSAKQKEEWRFWQAKVFAQNKKTTEQAQ
QIFQQLAKQRGFYPLLASAELNIDYAPAMDVFSSTSATDIHEKFSVELSRIAELREHNATQYMNLEWKALLEKANFEQKL
ALSQFATEQAWFDLGVEATIQAKAWGYLALRLPNAYLDWFDLHLNNKNVSRTFAMAIARQESAWKPYVSSHANAQGLMQL
LPSTAKQTAQEAGLPYTHQKQLFDPFDNIMLGTAHLQQLYDKYGNNRILIAAAYNAGASRVDRWLAKADGKLSMAEFIAS
IPFYETRGYVQNVLTYDVYYQWLQQQPQQKFSQDEYNRLY
>Mature_680_residues
MKLTKIALTYLLTLMSMSLAAVSVSVPEDKTQPTEASLTTTNLVQARQIYQKIHQLLQRSQSENTQRIVQALLAKIEDYP
LYPYAQYAYLKALKDQLSLAQIEAFQTDFPSFPLTTELQKQWLQQAQDKAEWQAIIHSPFRPKDMASRCIQLQAEYETQP
NSPAFSLKQWQQQVAQIWRNGASLPKACDTLFARWKEKGYPEETELKERAVLAFEQGNQALLASLSQQADQADTKRWLNE
LHQLSKNPLRLQHPQSAFFIDTLSADDPFAQRILLSHFSTLIKRLKETDIKNQHDPFEPYAQWANKLRLSEAQQRQWKKH
LISHLFDSENLNLQKWRDAQLFELKEDTLTERRLRTALREKTELTPWLDLLSNSAKQKEEWRFWQAKVFAQNKKTTEQAQ
QIFQQLAKQRGFYPLLASAELNIDYAPAMDVFSSTSATDIHEKFSVELSRIAELREHNATQYMNLEWKALLEKANFEQKL
ALSQFATEQAWFDLGVEATIQAKAWGYLALRLPNAYLDWFDLHLNNKNVSRTFAMAIARQESAWKPYVSSHANAQGLMQL
LPSTAKQTAQEAGLPYTHQKQLFDPFDNIMLGTAHLQQLYDKYGNNRILIAAAYNAGASRVDRWLAKADGKLSMAEFIAS
IPFYETRGYVQNVLTYDVYYQWLQQQPQQKFSQDEYNRLY

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082441, Length=648, Percent_Identity=32.8703703703704, Blast_Score=327, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011989
- InterPro:   IPR016026
- InterPro:   IPR008258
- InterPro:   IPR012289
- InterPro:   IPR008939
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 78917; Mature: 78917

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTKIALTYLLTLMSMSLAAVSVSVPEDKTQPTEASLTTTNLVQARQIYQKIHQLLQRS
CCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QSENTQRIVQALLAKIEDYPLYPYAQYAYLKALKDQLSLAQIEAFQTDFPSFPLTTELQK
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
QWLQQAQDKAEWQAIIHSPFRPKDMASRCIQLQAEYETQPNSPAFSLKQWQQQVAQIWRN
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
GASLPKACDTLFARWKEKGYPEETELKERAVLAFEQGNQALLASLSQQADQADTKRWLNE
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LHQLSKNPLRLQHPQSAFFIDTLSADDPFAQRILLSHFSTLIKRLKETDIKNQHDPFEPY
HHHHCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AQWANKLRLSEAQQRQWKKHLISHLFDSENLNLQKWRDAQLFELKEDTLTERRLRTALRE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KTELTPWLDLLSNSAKQKEEWRFWQAKVFAQNKKTTEQAQQIFQQLAKQRGFYPLLASAE
HHCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCC
LNIDYAPAMDVFSSTSATDIHEKFSVELSRIAELREHNATQYMNLEWKALLEKANFEQKL
CCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHCHHHHH
ALSQFATEQAWFDLGVEATIQAKAWGYLALRLPNAYLDWFDLHLNNKNVSRTFAMAIARQ
HHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHCHHHEEECCCCHHHHHHHHHHHH
ESAWKPYVSSHANAQGLMQLLPSTAKQTAQEAGLPYTHQKQLFDPFDNIMLGTAHLQQLY
HHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHH
DKYGNNRILIAAAYNAGASRVDRWLAKADGKLSMAEFIASIPFYETRGYVQNVLTYDVYY
HHHCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QWLQQQPQQKFSQDEYNRLY
HHHHHHHHHHHCHHHHHCCC
>Mature Secondary Structure
MKLTKIALTYLLTLMSMSLAAVSVSVPEDKTQPTEASLTTTNLVQARQIYQKIHQLLQRS
CCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QSENTQRIVQALLAKIEDYPLYPYAQYAYLKALKDQLSLAQIEAFQTDFPSFPLTTELQK
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
QWLQQAQDKAEWQAIIHSPFRPKDMASRCIQLQAEYETQPNSPAFSLKQWQQQVAQIWRN
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
GASLPKACDTLFARWKEKGYPEETELKERAVLAFEQGNQALLASLSQQADQADTKRWLNE
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LHQLSKNPLRLQHPQSAFFIDTLSADDPFAQRILLSHFSTLIKRLKETDIKNQHDPFEPY
HHHHCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AQWANKLRLSEAQQRQWKKHLISHLFDSENLNLQKWRDAQLFELKEDTLTERRLRTALRE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KTELTPWLDLLSNSAKQKEEWRFWQAKVFAQNKKTTEQAQQIFQQLAKQRGFYPLLASAE
HHCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCC
LNIDYAPAMDVFSSTSATDIHEKFSVELSRIAELREHNATQYMNLEWKALLEKANFEQKL
CCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHCHHHHH
ALSQFATEQAWFDLGVEATIQAKAWGYLALRLPNAYLDWFDLHLNNKNVSRTFAMAIARQ
HHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHCHHHEEECCCCHHHHHHHHHHHH
ESAWKPYVSSHANAQGLMQLLPSTAKQTAQEAGLPYTHQKQLFDPFDNIMLGTAHLQQLY
HHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHH
DKYGNNRILIAAAYNAGASRVDRWLAKADGKLSMAEFIASIPFYETRGYVQNVLTYDVYY
HHHCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QWLQQQPQQKFSQDEYNRLY
HHHHHHHHHHHCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]