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The map label for this gene is pth

Identifier: 15602029

GI number: 15602029

Start: 191089

End: 191673

Strand: Reverse

Name: pth

Synonym: PM0164

Alternate gene names: 15602029

Gene position: 191673-191089 (Counterclockwise)

Preceding gene: 15602034

Following gene: 15602028

Centisome position: 8.49

GC content: 40.34

Gene sequence:

>585_bases
ATGTCTGAAATAAAATTAATTGTTGGTTTGGGTAATCCGGGCGATAAATATGCCGATACCCGCCACAATGCGGGAGAATG
GTTAATCAATCGTTTAGCGCGCCAATTTCATTTTAGTTTAACGCCCGAGAGCAAATTTTCAGGCAAAACGGCACGCACCG
TCATCAACGGCAATGAAATCCGCTTTCTCGTACCAACAACCTTTATGAATTTGAGTGGTAAAGCCATCAGTAGCTTGGCA
AATTTCTATCGCATCAAACCAGAAGAGATTTTGGTCATTCATGATGAATTAGATTTACCACCGGGTGTAGCAAAAATTAA
ACAAGGTGGCGGACATGGTGGACACAACGGTTTGCGTGATACTATCGCGCAATTAGGCAACAATAAAAACTTCTATCGCT
TAAGAGTTGGCATTGGACATCCTGGTGATAAAAATTTGGTTTCAGCGTATGTGTTAAATAAACCGTCACTTACCGATTGG
CAACTGATTGACAAAGCTTTAGATGAAGCCACAAGTTGTGTAGATATTCTGATTAAAGATGGCATTACTAAAGCCACCAA
CCGTTTAAATGCGTTTAAAGCATAA

Upstream 100 bases:

>100_bases
CAAAATAAGGCAAGAATGGAGAAAATCTGTGTTTCAAAATTGAGAGTTACGCTATTTTCCGCTACAATAGCGCACTATTT
TGACTGTTGGAAGAAGATCA

Downstream 100 bases:

>100_bases
AAAAGATTAATAGTTAAAAAGTAAGGAAAAACTATGGGATTTAAATGTGGCATCGTGGGTTTACCTAACGTCGGTAAATC
AACCCTATTTAATGCATTAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSEIKLIVGLGNPGDKYADTRHNAGEWLINRLARQFHFSLTPESKFSGKTARTVINGNEIRFLVPTTFMNLSGKAISSLA
NFYRIKPEEILVIHDELDLPPGVAKIKQGGGHGGHNGLRDTIAQLGNNKNFYRLRVGIGHPGDKNLVSAYVLNKPSLTDW
QLIDKALDEATSCVDILIKDGITKATNRLNAFKA

Sequences:

>Translated_194_residues
MSEIKLIVGLGNPGDKYADTRHNAGEWLINRLARQFHFSLTPESKFSGKTARTVINGNEIRFLVPTTFMNLSGKAISSLA
NFYRIKPEEILVIHDELDLPPGVAKIKQGGGHGGHNGLRDTIAQLGNNKNFYRLRVGIGHPGDKNLVSAYVLNKPSLTDW
QLIDKALDEATSCVDILIKDGITKATNRLNAFKA
>Mature_193_residues
SEIKLIVGLGNPGDKYADTRHNAGEWLINRLARQFHFSLTPESKFSGKTARTVINGNEIRFLVPTTFMNLSGKAISSLAN
FYRIKPEEILVIHDELDLPPGVAKIKQGGGHGGHNGLRDTIAQLGNNKNFYRLRVGIGHPGDKNLVSAYVLNKPSLTDWQ
LIDKALDEATSCVDILIKDGITKATNRLNAFKA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=171, Percent_Identity=35.0877192982456, Blast_Score=100, Evalue=8e-22,
Organism=Escherichia coli, GI1787455, Length=191, Percent_Identity=63.3507853403141, Blast_Score=239, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6321983, Length=163, Percent_Identity=30.0613496932515, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PASMU (P57820)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245101.1
- ProteinModelPortal:   P57820
- SMR:   P57820
- GeneID:   1243511
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0164
- NMPDR:   fig|272843.1.peg.164
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   PMUL272843:PM0164-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21335; Mature: 21204

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIKLIVGLGNPGDKYADTRHNAGEWLINRLARQFHFSLTPESKFSGKTARTVINGNEI
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEECCCEE
RFLVPTTFMNLSGKAISSLANFYRIKPEEILVIHDELDLPPGVAKIKQGGGHGGHNGLRD
EEEECCCEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHH
TIAQLGNNKNFYRLRVGIGHPGDKNLVSAYVLNKPSLTDWQLIDKALDEATSCVDILIKD
HHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
GITKATNRLNAFKA
CCHHHHHHHHHCCC
>Mature Secondary Structure 
SEIKLIVGLGNPGDKYADTRHNAGEWLINRLARQFHFSLTPESKFSGKTARTVINGNEI
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEECCCEE
RFLVPTTFMNLSGKAISSLANFYRIKPEEILVIHDELDLPPGVAKIKQGGGHGGHNGLRD
EEEECCCEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHH
TIAQLGNNKNFYRLRVGIGHPGDKNLVSAYVLNKPSLTDWQLIDKALDEATSCVDILIKD
HHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
GITKATNRLNAFKA
CCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100