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The map label for this gene is gpo

Identifier: 30024038

GI number: 30024038

Start: 1401793

End: 1402266

Strand: Reverse

Name: gpo

Synonym: L0198

Alternate gene names: 30024038

Gene position: 1402266-1401793 (Counterclockwise)

Preceding gene: 15673348

Following gene: 15673345

Centisome position: 59.28

GC content: 33.33

Gene sequence:

>474_bases
ATGAATTTTTATGATTTTAGTGCCTTTAAAATGAACGGCGAAACTGTTTCAATGTCTGATTTTAAAGGCAAAGTTGTAAT
TGTGGTCAACACTGCAAGTAAATGTGGCTTTACACCGCAATTTGAAGGACTTGAAAAGTTGTATGAGAACTATAAAGACC
AAGGATTGGAAATTTTAGGTTTTCCCTGTAATCAATTTGTTAATCAAGACGCTGGCGAAAATTCGGAGATCAATGAATTT
TGTCAGTTAAATTATGGAGTCACTTTCCCCATGTTTCAAAAAATTAAAGTCAATGGTAAAGAAGCACATCCCCTTTATCA
ATTTTTGAAAAAAGAAGCAAAAGGGGCACTTAGCGGGACCATTAAATGGAATTTCACAAAATTTTTAATTGACCGAGAAG
GAAATGTTATTGAACGTTTTGCGCCAAAAACGGAACCTAAAGAAATGGAAGAAGAAATCCAAAAATTACTTTAA

Upstream 100 bases:

>100_bases
AAAATTTCTGTCAGTAAAATTTTACTGACAGCCATAAATTTTTACTGACAGAATCGGTATTGTCAATAAATAATTAAATA
AAAGTCATGGAGGCAATCAA

Downstream 100 bases:

>100_bases
TTAATTTCTTAAGGAAAAGTGTTTTAAAACTTGTAAAAGCTCAATTATTTTGCTAAACTAATAAACAATAAAACTTTTAA
TCTAGTCCAGAGAGGCTAGC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MNFYDFSAFKMNGETVSMSDFKGKVVIVVNTASKCGFTPQFEGLEKLYENYKDQGLEILGFPCNQFVNQDAGENSEINEF
CQLNYGVTFPMFQKIKVNGKEAHPLYQFLKKEAKGALSGTIKWNFTKFLIDREGNVIERFAPKTEPKEMEEEIQKLL

Sequences:

>Translated_157_residues
MNFYDFSAFKMNGETVSMSDFKGKVVIVVNTASKCGFTPQFEGLEKLYENYKDQGLEILGFPCNQFVNQDAGENSEINEF
CQLNYGVTFPMFQKIKVNGKEAHPLYQFLKKEAKGALSGTIKWNFTKFLIDREGNVIERFAPKTEPKEMEEEIQKLL
>Mature_157_residues
MNFYDFSAFKMNGETVSMSDFKGKVVIVVNTASKCGFTPQFEGLEKLYENYKDQGLEILGFPCNQFVNQDAGENSEINEF
CQLNYGVTFPMFQKIKVNGKEAHPLYQFLKKEAKGALSGTIKWNFTKFLIDREGNVIERFAPKTEPKEMEEEIQKLL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family

Homologues:

Organism=Homo sapiens, GI75709200, Length=155, Percent_Identity=45.1612903225806, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI90903240, Length=155, Percent_Identity=45.1612903225806, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI15618997, Length=157, Percent_Identity=37.5796178343949, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI192455698, Length=157, Percent_Identity=36.9426751592357, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=46.1538461538462, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4557629, Length=177, Percent_Identity=32.2033898305085, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI41406084, Length=183, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=32.0441988950276, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI6006001, Length=173, Percent_Identity=35.2601156069364, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI33186887, Length=177, Percent_Identity=31.0734463276836, Blast_Score=77, Evalue=8e-15,
Organism=Escherichia coli, GI1788003, Length=158, Percent_Identity=43.0379746835443, Blast_Score=146, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17506887, Length=155, Percent_Identity=47.741935483871, Blast_Score=153, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17535473, Length=146, Percent_Identity=47.2602739726027, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193210707, Length=159, Percent_Identity=45.2830188679245, Blast_Score=135, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71993584, Length=155, Percent_Identity=40.6451612903226, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17550320, Length=163, Percent_Identity=34.3558282208589, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI193209493, Length=163, Percent_Identity=32.5153374233129, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17507603, Length=105, Percent_Identity=38.0952380952381, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999642, Length=74, Percent_Identity=37.8378378378378, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193210709, Length=72, Percent_Identity=44.4444444444444, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993573, Length=94, Percent_Identity=32.9787234042553, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319721, Length=157, Percent_Identity=52.8662420382166, Blast_Score=177, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6322228, Length=156, Percent_Identity=51.9230769230769, Blast_Score=174, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6322826, Length=157, Percent_Identity=49.6815286624204, Blast_Score=158, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24656772, Length=159, Percent_Identity=45.2830188679245, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24656767, Length=159, Percent_Identity=45.2830188679245, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24656777, Length=159, Percent_Identity=45.2830188679245, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI85726443, Length=147, Percent_Identity=40.8163265306122, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPO_LACLA (Q9CFV1)

Other databases:

- EMBL:   AE005176
- PIR:   D86795
- RefSeq:   NP_267520.2
- ProteinModelPortal:   Q9CFV1
- SMR:   Q9CFV1
- PeroxiBase:   3753
- GeneID:   1115014
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0198
- NMPDR:   fig|272623.1.peg.1399
- HOGENOM:   HBG648990
- OMA:   NTASECA
- ProtClustDB:   CLSK824609
- BioCyc:   LLAC272623:L0198-MONOMER
- BRENDA:   1.11.1.9
- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR11592
- PIRSF:   PIRSF000303
- PRINTS:   PR01011

Pfam domain/function: PF00255 GSHPx; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.9

Molecular weight: Translated: 18024; Mature: 18024

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1; PS00763 GLUTATHIONE_PEROXID_2; PS51355 GLUTATHIONE_PEROXID_3

Important sites: ACT_SITE 35-35

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFYDFSAFKMNGETVSMSDFKGKVVIVVNTASKCGFTPQFEGLEKLYENYKDQGLEILG
CCCCCCEEEEECCCEEEECCCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHHHCCCEEEE
FPCNQFVNQDAGENSEINEFCQLNYGVTFPMFQKIKVNGKEAHPLYQFLKKEAKGALSGT
CCHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEECE
IKWNFTKFLIDREGNVIERFAPKTEPKEMEEEIQKLL
EEECEEEEEEECCCCCHHHCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MNFYDFSAFKMNGETVSMSDFKGKVVIVVNTASKCGFTPQFEGLEKLYENYKDQGLEILG
CCCCCCEEEEECCCEEEECCCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHHHCCCEEEE
FPCNQFVNQDAGENSEINEFCQLNYGVTFPMFQKIKVNGKEAHPLYQFLKKEAKGALSGT
CCHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEECE
IKWNFTKFLIDREGNVIERFAPKTEPKEMEEEIQKLL
EEECEEEEEEECCCCCHHHCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471