Click here to switch to the map view.

The map label for this gene is glmU

Identifier: 15673865

GI number: 15673865

Start: 1951088

End: 1952464

Strand: Reverse

Name: glmU

Synonym: L134450

Alternate gene names: 15673865

Gene position: 1952464-1951088 (Counterclockwise)

Preceding gene: 15673867

Following gene: 15673864

Centisome position: 82.54

GC content: 37.55

Gene sequence:

>1377_bases
ATGAATAAATTCGCAATTGTCTTGGCGGCTGGTAAAGGAACTCGTATGAAATCAGCACTTCCGAAGGTCTTACATCAAGT
GGCTGGAAAATCAATGCTTGCTCATGTTCTTACAAGTGTTTCTGAGGTCGAAATTGCTAAAAATGTCGTGATTGTTGGTC
ATGAAGCGGATCGTGTGATTGCAACTTTACCTAAAGGGACTCAATTTGTGAAACAAGTTGAGCAATTGGGAACGGGTCAT
GCCGTTCGGATTGCTGCGGATTTATTGGCAAATGAAGATGGAGCAACTCTTGTTATTGCTGGTGATACACCATTAATTAC
TGGACAAACGTTAGAAGCACTTTTTGACTATCACTTTGCACAAAATGCAACAGCAACTATCTTGACAGCAATTGCACCAA
ATCCAACAGGATATGGACGAATTATTCGTGATGAAAATGGCTCAGTAGAAAAGATTGTTGAGCAAAAAGATGCGAATGAT
TTTGAAAAATCAATTACCGAAATTAATACTGGGACTTACATTTTTGATAATAAGTCACTTTTCAAAGCCTTGAATGAAAT
CACAACTGATAATGCCCAAGGAGAGTATTATTTAACAGATGTCATTGAAATTTTCAAAAAAGCTGGTCAAACGGTAGCGG
CTCATATTCTTGATGATTTTGACGAAAGTTTAGGAGTTAATGACCGTGTTGCCCTTTCACAAGCTGAGTTGACGATGCGC
AAACGAATCAATCATCAACATATGGTGAATGGTGTAACGCTTATTGACCCTGCGACAACTTATATTGACAGTGAAGTTAC
GATTGGTGAAGAAACTGTGATTGAAGCAAATGTAACAATAAAAGGAAATACCTTTATTGGTAAAAATGTTTTGATTACAA
ATGGTAGCCGTATTGAAAATTCAGAAATCCATTCAAATTGTGAAGTTCGTAATTCAACGGTTGAAGAAAGCAGAATGAGT
GTTGGAAGTAATGTAGGACCTTATGCTCACTTGCGTCCCGGAACTGTTTTGAGCGAAGAAGTTCATGTTGGAAACTTTGT
CGAAATTAAAGGTTCAACGCTTGGTAAAGGTACAAAAGCTGGTCACTTAACTTATATTGGAAATGCAACGGTTGGTGAGA
AAGTGAACTTTGGTGCTGGAACAATTACAGCAAACTTTGATGGTAAAAATAAATTCAATACTGAAATTGATGACTTTGCC
TTTATTGGTTCGAATTCAACAATTATTGCTCCATTGCATATCGGTAAAAATGCCTTAACAGCAGCAGGCTCTGTTGTAAC
AGAAGATGTACCAGATGAAGCAGTCGAAATTGGACGTGGAAAACAAGTGAATAAACTTGGACGTGCTAAAAAAATGCCAC
ATTATCGTGGTCAATAA

Upstream 100 bases:

>100_bases
ATTGAGAGGATTTGAATTAAAAAGATAACGAAAATGCCCCTTGATTATGGTATAATTAGGTAAACATTTTATTTTATTTG
TAATAATAAAGGAGAAATCT

Downstream 100 bases:

>100_bases
TTAACAAATAAAAGAAAGAGTTTCTCCTGAAGCTCTTTCCTTCGATTTTGATGAGAAAACTATTCTTTAAATTATTTTAA
AAAGTTTTCGGAAGAAAGGA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLTSVSEVEIAKNVVIVGHEADRVIATLPKGTQFVKQVEQLGTGH
AVRIAADLLANEDGATLVIAGDTPLITGQTLEALFDYHFAQNATATILTAIAPNPTGYGRIIRDENGSVEKIVEQKDAND
FEKSITEINTGTYIFDNKSLFKALNEITTDNAQGEYYLTDVIEIFKKAGQTVAAHILDDFDESLGVNDRVALSQAELTMR
KRINHQHMVNGVTLIDPATTYIDSEVTIGEETVIEANVTIKGNTFIGKNVLITNGSRIENSEIHSNCEVRNSTVEESRMS
VGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKAGHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFA
FIGSNSTIIAPLHIGKNALTAAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ

Sequences:

>Translated_458_residues
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLTSVSEVEIAKNVVIVGHEADRVIATLPKGTQFVKQVEQLGTGH
AVRIAADLLANEDGATLVIAGDTPLITGQTLEALFDYHFAQNATATILTAIAPNPTGYGRIIRDENGSVEKIVEQKDAND
FEKSITEINTGTYIFDNKSLFKALNEITTDNAQGEYYLTDVIEIFKKAGQTVAAHILDDFDESLGVNDRVALSQAELTMR
KRINHQHMVNGVTLIDPATTYIDSEVTIGEETVIEANVTIKGNTFIGKNVLITNGSRIENSEIHSNCEVRNSTVEESRMS
VGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKAGHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFA
FIGSNSTIIAPLHIGKNALTAAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ
>Mature_458_residues
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLTSVSEVEIAKNVVIVGHEADRVIATLPKGTQFVKQVEQLGTGH
AVRIAADLLANEDGATLVIAGDTPLITGQTLEALFDYHFAQNATATILTAIAPNPTGYGRIIRDENGSVEKIVEQKDAND
FEKSITEINTGTYIFDNKSLFKALNEITTDNAQGEYYLTDVIEIFKKAGQTVAAHILDDFDESLGVNDRVALSQAELTMR
KRINHQHMVNGVTLIDPATTYIDSEVTIGEETVIEANVTIKGNTFIGKNVLITNGSRIENSEIHSNCEVRNSTVEESRMS
VGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKAGHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFA
FIGSNSTIIAPLHIGKNALTAAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=447, Percent_Identity=44.0715883668904, Blast_Score=348, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6320148, Length=366, Percent_Identity=25.1366120218579, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21355443, Length=367, Percent_Identity=25.6130790190736, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24644084, Length=367, Percent_Identity=25.6130790190736, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_LACLA (Q9CEF8)

Other databases:

- EMBL:   AE005176
- PIR:   C86860
- RefSeq:   NP_268040.1
- ProteinModelPortal:   Q9CEF8
- SMR:   Q9CEF8
- GeneID:   1115548
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L134450
- NMPDR:   fig|272623.1.peg.1929
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14354
- BioCyc:   LLAC272623:L134450-MONOMER
- BRENDA:   2.3.1.157
- BRENDA:   2.7.7.23
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49180; Mature: 49180

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 362-362 BINDING 72-72 BINDING 139-139 BINDING 154-154 BINDING 169-169 BINDING 404-404 BINDING 422-422 BINDING 439-439

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLTSVSEVEIAKNVVIVGHEADRVI
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEE
ATLPKGTQFVKQVEQLGTGHAVRIAADLLANEDGATLVIAGDTPLITGQTLEALFDYHFA
EECCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCCEEEEECCCCEECCHHHHHHHHHHHC
QNATATILTAIAPNPTGYGRIIRDENGSVEKIVEQKDANDFEKSITEINTGTYIFDNKSL
CCCCEEEEEEECCCCCCCCEEEECCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEECCHHH
FKALNEITTDNAQGEYYLTDVIEIFKKAGQTVAAHILDDFDESLGVNDRVALSQAELTMR
HHHHHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
KRINHQHMVNGVTLIDPATTYIDSEVTIGEETVIEANVTIKGNTFIGKNVLITNGSRIEN
HHCCHHHHHCCEEEECCCHHHCCCCEEECCCEEEEEEEEEECCEEECCEEEEECCCCCCC
SEIHSNCEVRNSTVEESRMSVGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKA
CHHCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCEECCCCCCCCEEEECCCCCCCCCCC
GHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFAFIGSNSTIIAPLHIGKNALT
CEEEEECCCCCCCEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCEEEEEEECCCCHHH
AAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ
HCCCHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLTSVSEVEIAKNVVIVGHEADRVI
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEE
ATLPKGTQFVKQVEQLGTGHAVRIAADLLANEDGATLVIAGDTPLITGQTLEALFDYHFA
EECCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCCEEEEECCCCEECCHHHHHHHHHHHC
QNATATILTAIAPNPTGYGRIIRDENGSVEKIVEQKDANDFEKSITEINTGTYIFDNKSL
CCCCEEEEEEECCCCCCCCEEEECCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEECCHHH
FKALNEITTDNAQGEYYLTDVIEIFKKAGQTVAAHILDDFDESLGVNDRVALSQAELTMR
HHHHHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
KRINHQHMVNGVTLIDPATTYIDSEVTIGEETVIEANVTIKGNTFIGKNVLITNGSRIEN
HHCCHHHHHCCEEEECCCHHHCCCCEEECCCEEEEEEEEEECCEEECCEEEEECCCCCCC
SEIHSNCEVRNSTVEESRMSVGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKA
CHHCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCEECCCCCCCCEEEECCCCCCCCCCC
GHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFAFIGSNSTIIAPLHIGKNALT
CEEEEECCCCCCCEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCEEEEEEECCCCHHH
AAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ
HCCCHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471