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The map label for this gene is yteD

Identifier: 15673857

GI number: 15673857

Start: 1944451

End: 1945779

Strand: Reverse

Name: yteD

Synonym: L127813

Alternate gene names: 15673857

Gene position: 1945779-1944451 (Counterclockwise)

Preceding gene: 15673858

Following gene: 15673856

Centisome position: 82.25

GC content: 33.63

Gene sequence:

>1329_bases
ATGAAAAATAAAAAAACATTTGGTCTTATCCTTTTTATTATTTTGTTTTCCTATTTCCTTATTTTAATGGATAACTCAAT
AATATTTACAAGTAGCTTAAAAATTTCTCAAGATTTAAAAATGAATGAATCAACTTTATCTTGGGTTTCTAATGCTTATA
CGATTACGTTTGGTGGTTTTCTTTTATTAGCAGGACGCCTGGGTGATTTATTAGGGCGAAAAATAATTTTCCTTCTTGGA
CTTTTCATTTTTGGATTTTCTAGTTTAGTTGTCGGTTTGTCAACTTCTTCAGAAATGATGATTATTGCCAGAGCAGTTCA
AGGAATTGGTTCGGCTATTCTTGCTCCAACAAGTTTAGCTTTATTAATGGATACATATAAAGGGGATTTAAGAGTTAGAG
CTATCTCATATTATGGATCAACTGCGGGAATTGGTTCAAGTTTTGGACTTATTCTAGGTGGCTGGCTCACTTCGGCTCTT
TCATGGCGTGTTGGCTTTTTATTAAATGTTCCTTTTAGTTTATTATTGATTATTTTAACTCTTGTTAATGTTCATCAAAG
CGATATCAAAGCTAGCAAAATTGACTTTTTGGGAAGTTTTCTGTCAGTCCTTATCTCAGTCCTATTTGTTTTCGGAATTA
CGGTAAGTAATTTGTTCATCATTATCCTCTCATTCATTTTAATTATCTTATTTATACTTTGGGAAAAAAAGTTAACTTAC
GCATTAATTCCTTTAGAATTATTTAAAAATAAAGTACGGACGGGTTCGTATGTTGCACGCTTTGCCTTTATGATGGCAAT
GTTGACTTACTGGTTTATTCTGCCGCAGATTATGCAAAAAATGTATCATTTTTCACCATTGCAATCCGGACTTGCTTTTC
TTCCTTTAACAATCGTAAATTTTATCGCGGCTCTTTTTCTTCCTAGATTAACTAGAGCATTAGGAAATAGTAAAGTAATG
ATCTTAGGACAAGTGATTTTACTGACTGGAATGATTTTGTCATTAGTTTCGCAACCAGAATGGGGATATTTCTATGCGAT
GGTTTTTCAAATGATGATTATTGGATTAGGGCAAGGTTGGCTTCTTGCTCCGCTGACGGCAGCGGGAGTAGAAGAGGTCA
GCCCAGAATTATCAGGAGCTGCATCAGGTTTGACAAATATGATGCATCAACTTGGAGGACCTGTTGGTTTATCTATTGTT
GTGTTATTTAGCTCAAATATTGTTGACTTAAGTGCTTATTATCATTTGGTCATGGGATTCATCACCGCTTTTCTATCAGT
AGGCCTTCTTGTCTTAATTTTTACTAGAACAGACAATAATAAAAAATAA

Upstream 100 bases:

>100_bases
GCTCTGTCAGTAACTTTTTTGTCAGTATTATGCTTACAAAGCATAATAATAACTAAAATAAGCATTTCTAATCAGTGAAT
TTTTATTTTAAAATAAATCT

Downstream 100 bases:

>100_bases
AAGGAGAAAAAATGCAAAGAAAATTAACATTAAATGATGGCAATGTCATTCCCCAATTCGGTTTGGGACTTTATCAGCTT
CCAGAAGGAACAGAAACGCA

Product: transmembrane efflux protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKNKKTFGLILFIILFSYFLILMDNSIIFTSSLKISQDLKMNESTLSWVSNAYTITFGGFLLLAGRLGDLLGRKIIFLLG
LFIFGFSSLVVGLSTSSEMMIIARAVQGIGSAILAPTSLALLMDTYKGDLRVRAISYYGSTAGIGSSFGLILGGWLTSAL
SWRVGFLLNVPFSLLLIILTLVNVHQSDIKASKIDFLGSFLSVLISVLFVFGITVSNLFIIILSFILIILFILWEKKLTY
ALIPLELFKNKVRTGSYVARFAFMMAMLTYWFILPQIMQKMYHFSPLQSGLAFLPLTIVNFIAALFLPRLTRALGNSKVM
ILGQVILLTGMILSLVSQPEWGYFYAMVFQMMIIGLGQGWLLAPLTAAGVEEVSPELSGAASGLTNMMHQLGGPVGLSIV
VLFSSNIVDLSAYYHLVMGFITAFLSVGLLVLIFTRTDNNKK

Sequences:

>Translated_442_residues
MKNKKTFGLILFIILFSYFLILMDNSIIFTSSLKISQDLKMNESTLSWVSNAYTITFGGFLLLAGRLGDLLGRKIIFLLG
LFIFGFSSLVVGLSTSSEMMIIARAVQGIGSAILAPTSLALLMDTYKGDLRVRAISYYGSTAGIGSSFGLILGGWLTSAL
SWRVGFLLNVPFSLLLIILTLVNVHQSDIKASKIDFLGSFLSVLISVLFVFGITVSNLFIIILSFILIILFILWEKKLTY
ALIPLELFKNKVRTGSYVARFAFMMAMLTYWFILPQIMQKMYHFSPLQSGLAFLPLTIVNFIAALFLPRLTRALGNSKVM
ILGQVILLTGMILSLVSQPEWGYFYAMVFQMMIIGLGQGWLLAPLTAAGVEEVSPELSGAASGLTNMMHQLGGPVGLSIV
VLFSSNIVDLSAYYHLVMGFITAFLSVGLLVLIFTRTDNNKK
>Mature_442_residues
MKNKKTFGLILFIILFSYFLILMDNSIIFTSSLKISQDLKMNESTLSWVSNAYTITFGGFLLLAGRLGDLLGRKIIFLLG
LFIFGFSSLVVGLSTSSEMMIIARAVQGIGSAILAPTSLALLMDTYKGDLRVRAISYYGSTAGIGSSFGLILGGWLTSAL
SWRVGFLLNVPFSLLLIILTLVNVHQSDIKASKIDFLGSFLSVLISVLFVFGITVSNLFIIILSFILIILFILWEKKLTY
ALIPLELFKNKVRTGSYVARFAFMMAMLTYWFILPQIMQKMYHFSPLQSGLAFLPLTIVNFIAALFLPRLTRALGNSKVM
ILGQVILLTGMILSLVSQPEWGYFYAMVFQMMIIGLGQGWLLAPLTAAGVEEVSPELSGAASGLTNMMHQLGGPVGLSIV
VLFSSNIVDLSAYYHLVMGFITAFLSVGLLVLIFTRTDNNKK

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=458, Percent_Identity=22.4890829694323, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789042, Length=401, Percent_Identity=25.1870324189526, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI87081983, Length=427, Percent_Identity=25.9953161592506, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788710, Length=306, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788392, Length=449, Percent_Identity=23.162583518931, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324954, Length=392, Percent_Identity=28.0612244897959, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323735, Length=253, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323520, Length=426, Percent_Identity=23.943661971831, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48627; Mature: 48627

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKKTFGLILFIILFSYFLILMDNSIIFTSSLKISQDLKMNESTLSWVSNAYTITFGGF
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCCHHHHHHHHCCEEEEHHHH
LLLAGRLGDLLGRKIIFLLGLFIFGFSSLVVGLSTSSEMMIIARAVQGIGSAILAPTSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLMDTYKGDLRVRAISYYGSTAGIGSSFGLILGGWLTSALSWRVGFLLNVPFSLLLIILT
HHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LVNVHQSDIKASKIDFLGSFLSVLISVLFVFGITVSNLFIIILSFILIILFILWEKKLTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIPLELFKNKVRTGSYVARFAFMMAMLTYWFILPQIMQKMYHFSPLQSGLAFLPLTIVN
HEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FIAALFLPRLTRALGNSKVMILGQVILLTGMILSLVSQPEWGYFYAMVFQMMIIGLGQGW
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCH
LLAPLTAAGVEEVSPELSGAASGLTNMMHQLGGPVGLSIVVLFSSNIVDLSAYYHLVMGF
HHHHHHHHCHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHEEECCCCHHHHHHHHHHHHH
ITAFLSVGLLVLIFTRTDNNKK
HHHHHHHHHHHEEEEECCCCCC
>Mature Secondary Structure
MKNKKTFGLILFIILFSYFLILMDNSIIFTSSLKISQDLKMNESTLSWVSNAYTITFGGF
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCCHHHHHHHHCCEEEEHHHH
LLLAGRLGDLLGRKIIFLLGLFIFGFSSLVVGLSTSSEMMIIARAVQGIGSAILAPTSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLMDTYKGDLRVRAISYYGSTAGIGSSFGLILGGWLTSALSWRVGFLLNVPFSLLLIILT
HHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LVNVHQSDIKASKIDFLGSFLSVLISVLFVFGITVSNLFIIILSFILIILFILWEKKLTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIPLELFKNKVRTGSYVARFAFMMAMLTYWFILPQIMQKMYHFSPLQSGLAFLPLTIVN
HEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FIAALFLPRLTRALGNSKVMILGQVILLTGMILSLVSQPEWGYFYAMVFQMMIIGLGQGW
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCH
LLAPLTAAGVEEVSPELSGAASGLTNMMHQLGGPVGLSIVVLFSSNIVDLSAYYHLVMGF
HHHHHHHHCHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHEEECCCCHHHHHHHHHHHHH
ITAFLSVGLLVLIFTRTDNNKK
HHHHHHHHHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]