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The map label for this gene is aroC

Identifier: 15673734

GI number: 15673734

Start: 1810217

End: 1811383

Strand: Reverse

Name: aroC

Synonym: L0059

Alternate gene names: 15673734

Gene position: 1811383-1810217 (Counterclockwise)

Preceding gene: 15673735

Following gene: 15673733

Centisome position: 76.57

GC content: 41.05

Gene sequence:

>1167_bases
ATGCGTTATTTTACAGCGGGAGAATCTCACGGCCCAAGACTTACAGCAATTATTGAAGGAGTGCCAGCCGGTCTCTCATT
GTCAGCAGAAGATATTAATATTGAACTTAAACGTCGTCAAGGCGGCTATGGTCGTGGCGGACGGATGAAAATTGAGTCTG
ACCAAGTTGAAATTACTTCAGGCGTTCGACACGGAAAAACAATTGGTAGCCCGATTACACTTAATGTTACAAACCGTGAT
TTCAAGAATTGGGAACAGATTATGGCAGCCCAAGATGTTGAAGATAAAATTAAAAAGCAACGTCGTTTGACCAAACCACG
CCCAGGACATGCCGATTTAGTTGGCGGAATGAAATATGAATTTGAAGACTTACGAAATGTTTTAGAACGTTCGTCAGCGC
GTGAAACAACAATGCGTGTTGCGGTTGGAGCTGTGGCAAAAAAACTACTTCACGAATTAGAAATTGAAATAGCTAATCAT
GTCGTAAATTTTGGCGGACGAGAAATTACAAGTCCAGAAAATTTAAGTGTTCAAGATATTCGTCAGACAGCTGGCCTTAG
TGATTTGTCTATTTTTGATGAGAGTCAAGCAGAAGAATTACGCAATTACATCGACCAAATAAAAAAAGCTGGAGATACAA
TTGGTGGAATAATTGAAACCAGAGTAGAAGGAGTTCCGGCTGGTCTTGGTTCCTACGTCCAATATGACAGAAAGTTGGAT
GCAAAAATTGCTGCTGCGGTTGTTTCTATCAATGCCTTTAAAGGAGTTGAATTTGGACTTGGATTTGAAGCAGGAAAACG
ACCAGGAAGTCAAGTGATGGATGAAATCATCTGGTCTGAGGATAAAGGCTACACTCGTTCAAGTAATCAGTTAGGCGGTT
TTGAGGGAGGAATGACAAATGGTGAACAAGTCATCGTCCGTGGAGTCATGAAACCTATTCCAACATTGTATAAACCCTTG
ATGTCTATTGATATCGAAAGCCATGAACCCTACAAAGCAAGTGTAGAACGTTCTGACCCAACCGCTCTTCCAGCAGCAGG
AGTTGTGATGGAAAATGTAGTAGCAACGGTAGTCGCTCAAGAAATCTGTGATAAATTTGATTCAGATACAATGAATGAAC
TAAGAGACGCTGTAGCCAGTTACAAAAAGCGCTTGTCAGAATATTAA

Upstream 100 bases:

>100_bases
TCTTTCAGCAAAAAATTCACAGCAAATTAATAAATTAACAGATATTATTCAAATTTTTGAAATGAAATAAGTAAAAAGTT
ACTAAAAATGGAGGTATAAA

Downstream 100 bases:

>100_bases
AAAAAACAAAGCCTATCTTGGGCTTTTTTTATAAAATAAATAACTTACGAATTTGTAAGTTTTCAGGTGTACATTTCTTG
TTACAATGAATTTATCAAGA

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MRYFTAGESHGPRLTAIIEGVPAGLSLSAEDINIELKRRQGGYGRGGRMKIESDQVEITSGVRHGKTIGSPITLNVTNRD
FKNWEQIMAAQDVEDKIKKQRRLTKPRPGHADLVGGMKYEFEDLRNVLERSSARETTMRVAVGAVAKKLLHELEIEIANH
VVNFGGREITSPENLSVQDIRQTAGLSDLSIFDESQAEELRNYIDQIKKAGDTIGGIIETRVEGVPAGLGSYVQYDRKLD
AKIAAAVVSINAFKGVEFGLGFEAGKRPGSQVMDEIIWSEDKGYTRSSNQLGGFEGGMTNGEQVIVRGVMKPIPTLYKPL
MSIDIESHEPYKASVERSDPTALPAAGVVMENVVATVVAQEICDKFDSDTMNELRDAVASYKKRLSEY

Sequences:

>Translated_388_residues
MRYFTAGESHGPRLTAIIEGVPAGLSLSAEDINIELKRRQGGYGRGGRMKIESDQVEITSGVRHGKTIGSPITLNVTNRD
FKNWEQIMAAQDVEDKIKKQRRLTKPRPGHADLVGGMKYEFEDLRNVLERSSARETTMRVAVGAVAKKLLHELEIEIANH
VVNFGGREITSPENLSVQDIRQTAGLSDLSIFDESQAEELRNYIDQIKKAGDTIGGIIETRVEGVPAGLGSYVQYDRKLD
AKIAAAVVSINAFKGVEFGLGFEAGKRPGSQVMDEIIWSEDKGYTRSSNQLGGFEGGMTNGEQVIVRGVMKPIPTLYKPL
MSIDIESHEPYKASVERSDPTALPAAGVVMENVVATVVAQEICDKFDSDTMNELRDAVASYKKRLSEY
>Mature_388_residues
MRYFTAGESHGPRLTAIIEGVPAGLSLSAEDINIELKRRQGGYGRGGRMKIESDQVEITSGVRHGKTIGSPITLNVTNRD
FKNWEQIMAAQDVEDKIKKQRRLTKPRPGHADLVGGMKYEFEDLRNVLERSSARETTMRVAVGAVAKKLLHELEIEIANH
VVNFGGREITSPENLSVQDIRQTAGLSDLSIFDESQAEELRNYIDQIKKAGDTIGGIIETRVEGVPAGLGSYVQYDRKLD
AKIAAAVVSINAFKGVEFGLGFEAGKRPGSQVMDEIIWSEDKGYTRSSNQLGGFEGGMTNGEQVIVRGVMKPIPTLYKPL
MSIDIESHEPYKASVERSDPTALPAAGVVMENVVATVVAQEICDKFDSDTMNELRDAVASYKKRLSEY

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=365, Percent_Identity=37.2602739726027, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321290, Length=371, Percent_Identity=32.6145552560647, Blast_Score=158, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_LACLA (Q9CET2)

Other databases:

- EMBL:   AE005176
- PIR:   H86843
- RefSeq:   NP_267908.1
- ProteinModelPortal:   Q9CET2
- SMR:   Q9CET2
- GeneID:   1115415
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0059
- NMPDR:   fig|272623.1.peg.1796
- HOGENOM:   HBG292336
- OMA:   GSEAHDE
- ProtClustDB:   PRK05382
- BioCyc:   LLAC272623:L0059-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_B
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 42635; Mature: 42635

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFTAGESHGPRLTAIIEGVPAGLSLSAEDINIELKRRQGGYGRGGRMKIESDQVEITS
CCEECCCCCCCCEEEEEEECCCCCCEECCCCCEEEEEECCCCCCCCCCEEECCCCCHHHH
GVRHGKTIGSPITLNVTNRDFKNWEQIMAAQDVEDKIKKQRRLTKPRPGHADLVGGMKYE
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHCCCCCC
FEDLRNVLERSSARETTMRVAVGAVAKKLLHELEIEIANHVVNFGGREITSPENLSVQDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
RQTAGLSDLSIFDESQAEELRNYIDQIKKAGDTIGGIIETRVEGVPAGLGSYVQYDRKLD
HHHCCCCHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AKIAAAVVSINAFKGVEFGLGFEAGKRPGSQVMDEIIWSEDKGYTRSSNQLGGFEGGMTN
HHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GEQVIVRGVMKPIPTLYKPLMSIDIESHEPYKASVERSDPTALPAAGVVMENVVATVVAQ
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EICDKFDSDTMNELRDAVASYKKRLSEY
HHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYFTAGESHGPRLTAIIEGVPAGLSLSAEDINIELKRRQGGYGRGGRMKIESDQVEITS
CCEECCCCCCCCEEEEEEECCCCCCEECCCCCEEEEEECCCCCCCCCCEEECCCCCHHHH
GVRHGKTIGSPITLNVTNRDFKNWEQIMAAQDVEDKIKKQRRLTKPRPGHADLVGGMKYE
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHCCCCCC
FEDLRNVLERSSARETTMRVAVGAVAKKLLHELEIEIANHVVNFGGREITSPENLSVQDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
RQTAGLSDLSIFDESQAEELRNYIDQIKKAGDTIGGIIETRVEGVPAGLGSYVQYDRKLD
HHHCCCCHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AKIAAAVVSINAFKGVEFGLGFEAGKRPGSQVMDEIIWSEDKGYTRSSNQLGGFEGGMTN
HHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GEQVIVRGVMKPIPTLYKPLMSIDIESHEPYKASVERSDPTALPAAGVVMENVVATVVAQ
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EICDKFDSDTMNELRDAVASYKKRLSEY
HHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471