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The map label for this gene is mvaA

Identifier: 15673552

GI number: 15673552

Start: 1610684

End: 1611916

Strand: Reverse

Name: mvaA

Synonym: L10433

Alternate gene names: 15673552

Gene position: 1611916-1610684 (Counterclockwise)

Preceding gene: 15673553

Following gene: 15673551

Centisome position: 68.14

GC content: 36.66

Gene sequence:

>1233_bases
ATGAGAAAAAAATTTTATCAAATGTCGCCCAAAGAGCGATTAGATTCATTGAATCTGTCAGAAGATACTCAGGAAGTTTT
GAGTGAAATGGCTTTAGATACAAATATTTTAAACAATCTAATTGAAAATCAAATTTCCGAATTTGAATTGCCAATGGGAC
TTGCTCAAAATTTTGTCATTAATGGAAAAGAATACATCGTTCCGATGGTTACAGAAGAACCATCAGTTATAGCTGCTGCG
AGTAATGGAGCAAAAATAGCGGAAAGTTTTACGGCTAAAATAGATGAACGGTTAATGCGTGGGCAAATTGTATTTTATGA
CGTAAAGAAACCAGAAGAAATTATTAAGAAAATATCTGAATGCAAAAATGAAATATTTGAACAAGCTAAGCTTTCGTATC
CTTCAATTATTAAGCGTGGGGGCGGTTTGAGAGAAATTTCGAGCAGACTTTTTTCAAGTGAGAAATTTATTTCAGTTGAT
TTCAAAGTGGATGTCAAAGATGCAATGGGTGCCAATATTATTAATTCTATATTAGAAGGTGTAGCAGAACTTTTTCGTGG
CTGGTTTTCTGAGGAAAAAATTCTGTTTAGCATCCTTTCAAACTATGCAACTGAATCTTTAGTAAAAGTGAGCTGTGAAA
TTTCAGTTGATGCTCTTTCAAAAAAAACAAATGGTTTAGAAATTGCTCAAAAAATTGCAGTTGCTTCACAATACTCAAAA
ATTGATCCTTACCGTGCTAGCACACACAATAAAGGGATTATGAATGGGATTAATGCTGTAATTCTTGCAACAGGAAATGA
TACGCGAGCTATTTCAGCAGCAATTCATGCTTATGCAGCAAAAGAAGGAACATATCAAGGTTTGGCTAAATGGGAAGTTC
ATGCCGAAAAGTTATTTGGAGAGTTAGAAATTCCTTTACCTGTGGCGACCGTTGGTGGTGGGGTGAAAGTCTTACCTAAA
GCACAAGCGGCAATGGAAATTTTAGGAATCACAGATGCTAGAGAACTGGCCAAAGTTATCGCCGCAGTTGGTTTAGCACA
AAATTTAGCAGCTTTGCGCGCACTTGTTTCAGAAGGAATTCAACAAGGACATATGAGCTTACAGGCTCGCTCTTTGGCAT
TATCCGTGGGTGCAAAAGCAGATGAGATAGCAGTCATAAGTCAGCAACTTCGGCAGGAAAAAGTGATGAATCAAGAAGTA
GCTCGCCGTTTATTAAATAGTCTCAGAAACTAA

Upstream 100 bases:

>100_bases
TTAAAAAATCCTAACCTTTAAAAATTATTGTGGTTTAAACAAGTAATTTTTAAGAAATTAATGGAGGAATTGCCCAGCTT
ATCTGGGCATTTTTGAAAAT

Downstream 100 bases:

>100_bases
AAAAGAACTGTCAAGATTTTTTCTTGACAGGCCGAAATTAGTCTGCTATAATATTAAATATAATAAAAATAGAAATAGGA
AATATAGAATGTCTGTAAAA

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRKKFYQMSPKERLDSLNLSEDTQEVLSEMALDTNILNNLIENQISEFELPMGLAQNFVINGKEYIVPMVTEEPSVIAAA
SNGAKIAESFTAKIDERLMRGQIVFYDVKKPEEIIKKISECKNEIFEQAKLSYPSIIKRGGGLREISSRLFSSEKFISVD
FKVDVKDAMGANIINSILEGVAELFRGWFSEEKILFSILSNYATESLVKVSCEISVDALSKKTNGLEIAQKIAVASQYSK
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKEGTYQGLAKWEVHAEKLFGELEIPLPVATVGGGVKVLPK
AQAAMEILGITDARELAKVIAAVGLAQNLAALRALVSEGIQQGHMSLQARSLALSVGAKADEIAVISQQLRQEKVMNQEV
ARRLLNSLRN

Sequences:

>Translated_410_residues
MRKKFYQMSPKERLDSLNLSEDTQEVLSEMALDTNILNNLIENQISEFELPMGLAQNFVINGKEYIVPMVTEEPSVIAAA
SNGAKIAESFTAKIDERLMRGQIVFYDVKKPEEIIKKISECKNEIFEQAKLSYPSIIKRGGGLREISSRLFSSEKFISVD
FKVDVKDAMGANIINSILEGVAELFRGWFSEEKILFSILSNYATESLVKVSCEISVDALSKKTNGLEIAQKIAVASQYSK
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKEGTYQGLAKWEVHAEKLFGELEIPLPVATVGGGVKVLPK
AQAAMEILGITDARELAKVIAAVGLAQNLAALRALVSEGIQQGHMSLQARSLALSVGAKADEIAVISQQLRQEKVMNQEV
ARRLLNSLRN
>Mature_410_residues
MRKKFYQMSPKERLDSLNLSEDTQEVLSEMALDTNILNNLIENQISEFELPMGLAQNFVINGKEYIVPMVTEEPSVIAAA
SNGAKIAESFTAKIDERLMRGQIVFYDVKKPEEIIKKISECKNEIFEQAKLSYPSIIKRGGGLREISSRLFSSEKFISVD
FKVDVKDAMGANIINSILEGVAELFRGWFSEEKILFSILSNYATESLVKVSCEISVDALSKKTNGLEIAQKIAVASQYSK
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKEGTYQGLAKWEVHAEKLFGELEIPLPVATVGGGVKVLPK
AQAAMEILGITDARELAKVIAAVGLAQNLAALRALVSEGIQQGHMSLQARSLALSVGAKADEIAVISQQLRQEKVMNQEV
ARRLLNSLRN

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=367, Percent_Identity=22.8882833787466, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281362379, Length=368, Percent_Identity=23.0978260869565, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553469, Length=368, Percent_Identity=23.0978260869565, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24649399, Length=368, Percent_Identity=23.0978260869565, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 44905; Mature: 44905

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKFYQMSPKERLDSLNLSEDTQEVLSEMALDTNILNNLIENQISEFELPMGLAQNFVI
CCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEE
NGKEYIVPMVTEEPSVIAAASNGAKIAESFTAKIDERLMRGQIVFYDVKKPEEIIKKISE
CCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
CKNEIFEQAKLSYPSIIKRGGGLREISSRLFSSEKFISVDFKVDVKDAMGANIINSILEG
HHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEECHHHHCHHHHHHHHHH
VAELFRGWFSEEKILFSILSNYATESLVKVSCEISVDALSKKTNGLEIAQKIAVASQYSK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHH
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKEGTYQGLAKWEVHAEKLFG
CCCCCCCCCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHC
ELEIPLPVATVGGGVKVLPKAQAAMEILGITDARELAKVIAAVGLAQNLAALRALVSEGI
CCCCCCCEEECCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQGHMSLQARSLALSVGAKADEIAVISQQLRQEKVMNQEVARRLLNSLRN
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKKFYQMSPKERLDSLNLSEDTQEVLSEMALDTNILNNLIENQISEFELPMGLAQNFVI
CCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEE
NGKEYIVPMVTEEPSVIAAASNGAKIAESFTAKIDERLMRGQIVFYDVKKPEEIIKKISE
CCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
CKNEIFEQAKLSYPSIIKRGGGLREISSRLFSSEKFISVDFKVDVKDAMGANIINSILEG
HHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEECHHHHCHHHHHHHHHH
VAELFRGWFSEEKILFSILSNYATESLVKVSCEISVDALSKKTNGLEIAQKIAVASQYSK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHH
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKEGTYQGLAKWEVHAEKLFG
CCCCCCCCCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHC
ELEIPLPVATVGGGVKVLPKAQAAMEILGITDARELAKVIAAVGLAQNLAALRALVSEGI
CCCCCCCEEECCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQGHMSLQARSLALSVGAKADEIAVISQQLRQEKVMNQEVARRLLNSLRN
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]