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The map label for this gene is hemH

Identifier: 15673549

GI number: 15673549

Start: 1608782

End: 1609726

Strand: Reverse

Name: hemH

Synonym: L0194

Alternate gene names: 15673549

Gene position: 1609726-1608782 (Counterclockwise)

Preceding gene: 15673550

Following gene: 15673548

Centisome position: 68.05

GC content: 34.39

Gene sequence:

>945_bases
ATGGATAAGAAAAAAGGAATCTTATTAGTAGCTTTGGGAACTCCGCGCTCATGTGAAGCAGATGATGTGAGGGATTATTT
AAAAGAATTTTTGGGTGACCCTCTTGTTATACAAAAACCAAGATGGCTTTGGTTGCCGATTTTAAATGGAATTATTTTAA
AAGTTAGACCGCAAAAATCAGCAGAGATGTATAAAAAAATCTGGACAGATGAAGGTTCCCCTTTGATGATTTACACAGTA
GCACAAGCAAAGCAACTACAGGATATGCGCGAAGATTTTGATGTTCGTTTTGCCATGACTTACGGAGAGCCACGCATTGA
TAAAGTAATCGCTGAGATGAAAGAATCTGGTGTTGAAGAAATTACTGTTCTTCCACTTTACCCTCAATATTCTTTAACAA
CAGTTGAACCTGTAATTCAACAAGTTAAAAAAATTGATGATAAGATAAAAGTAATTAGAGATTTCCACAAAGTAGAATCT
TATAGCGATTTACTTGCAGAGTCTATTAGAGAAAAGTGGCAAGCAAATGACTATGATAAATTGGTCCTTAGCTATCATGG
AATTCCCTTGTCCTACGTGACCAAGAAAAAAGATGCTTATGAAGAGCAATGTAAAGAAACAACACGTTTGGTAGTAAGTA
AACTTGGTTTGAGGGAAGAAGAATACGAGCATACTTATCAATCAAAATTTGGTCCTGAAAAATGGTTAGAACCTGCGACT
ATTGATAGAGTTGCTGAACTTCCCAAAGAAAATGCTAAAAAAGTATTGATCTGTTCACCAGCATTCGTTGCAGATTGTTT
AGAAACTTTATTTGAATTAGAAATTGAAAATAAAGAAGTATTTGTTGAAAATGGCGGAGAAACATTTGATTTTGTTCATC
CTTTTAATGACTCTTTAGACTTTACTAGAGTATTAAGTGAAGTAGTTGACCAAAATAGACTCTGA

Upstream 100 bases:

>100_bases
TTGTATGAAAAATTATGCTAGAATGAAAAATATTGATTAACAATTGTAGATACAATCGGTTATAAATATAAATAAACTGA
TTTTTTATATAGGTGGAATA

Downstream 100 bases:

>100_bases
GAAATAAAATCATTATTTTATTAGTTTTGGCCTTTAAATTTTATAACATTACTAAAGAGAAATAGGATTTGTTATAATGG
TTCATAATATGCTAAAAATA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MDKKKGILLVALGTPRSCEADDVRDYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKSAEMYKKIWTDEGSPLMIYTV
AQAKQLQDMREDFDVRFAMTYGEPRIDKVIAEMKESGVEEITVLPLYPQYSLTTVEPVIQQVKKIDDKIKVIRDFHKVES
YSDLLAESIREKWQANDYDKLVLSYHGIPLSYVTKKKDAYEEQCKETTRLVVSKLGLREEEYEHTYQSKFGPEKWLEPAT
IDRVAELPKENAKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLDFTRVLSEVVDQNRL

Sequences:

>Translated_314_residues
MDKKKGILLVALGTPRSCEADDVRDYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKSAEMYKKIWTDEGSPLMIYTV
AQAKQLQDMREDFDVRFAMTYGEPRIDKVIAEMKESGVEEITVLPLYPQYSLTTVEPVIQQVKKIDDKIKVIRDFHKVES
YSDLLAESIREKWQANDYDKLVLSYHGIPLSYVTKKKDAYEEQCKETTRLVVSKLGLREEEYEHTYQSKFGPEKWLEPAT
IDRVAELPKENAKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLDFTRVLSEVVDQNRL
>Mature_314_residues
MDKKKGILLVALGTPRSCEADDVRDYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKSAEMYKKIWTDEGSPLMIYTV
AQAKQLQDMREDFDVRFAMTYGEPRIDKVIAEMKESGVEEITVLPLYPQYSLTTVEPVIQQVKKIDDKIKVIRDFHKVES
YSDLLAESIREKWQANDYDKLVLSYHGIPLSYVTKKKDAYEEQCKETTRLVVSKLGLREEEYEHTYQSKFGPEKWLEPAT
IDRVAELPKENAKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLDFTRVLSEVVDQNRL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=338, Percent_Identity=25.4437869822485, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=26.1261261261261, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786681, Length=317, Percent_Identity=36.5930599369085, Blast_Score=220, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6324750, Length=314, Percent_Identity=24.8407643312102, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17864156, Length=335, Percent_Identity=27.4626865671642, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_LACLA (Q9CFB4)

Other databases:

- EMBL:   AE005176
- PIR:   G86820
- RefSeq:   NP_267723.1
- ProteinModelPortal:   Q9CFB4
- SMR:   Q9CFB4
- GeneID:   1115227
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0194
- NMPDR:   fig|272623.1.peg.1609
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   CLSK697807
- BioCyc:   LLAC272623:L0194-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36436; Mature: 36436

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKKGILLVALGTPRSCEADDVRDYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKS
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEHHHHCCEEEEECCCHH
AEMYKKIWTDEGSPLMIYTVAQAKQLQDMREDFDVRFAMTYGEPRIDKVIAEMKESGVEE
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCE
ITVLPLYPQYSLTTVEPVIQQVKKIDDKIKVIRDFHKVESYSDLLAESIREKWQANDYDK
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LVLSYHGIPLSYVTKKKDAYEEQCKETTRLVVSKLGLREEEYEHTYQSKFGPEKWLEPAT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCCHH
IDRVAELPKENAKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLD
HHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHEECCCCEEEEECCCCEEEEECCCCCCHH
FTRVLSEVVDQNRL
HHHHHHHHHHCCCC
>Mature Secondary Structure
MDKKKGILLVALGTPRSCEADDVRDYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKS
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEHHHHCCEEEEECCCHH
AEMYKKIWTDEGSPLMIYTVAQAKQLQDMREDFDVRFAMTYGEPRIDKVIAEMKESGVEE
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCE
ITVLPLYPQYSLTTVEPVIQQVKKIDDKIKVIRDFHKVESYSDLLAESIREKWQANDYDK
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LVLSYHGIPLSYVTKKKDAYEEQCKETTRLVVSKLGLREEEYEHTYQSKFGPEKWLEPAT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCCHH
IDRVAELPKENAKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLD
HHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHEECCCCEEEEECCCCEEEEECCCCCCHH
FTRVLSEVVDQNRL
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471