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The map label for this gene is clpB

Identifier: 15673507

GI number: 15673507

Start: 1566658

End: 1569261

Strand: Reverse

Name: clpB

Synonym: L166407

Alternate gene names: 15673507

Gene position: 1569261-1566658 (Counterclockwise)

Preceding gene: 15673509

Following gene: 15673506

Centisome position: 66.34

GC content: 37.98

Gene sequence:

>2604_bases
ATGGACATCGAAAAAATGACAACAACGATGCAAGAAGCACTTGGTTCAGCGCAACAAATTGCGCAAGTTCGTCATCACCA
AGTGATTGAAGTTCCACATTTATGGCGAATTTTTGTTCAACCTAATAGTTTTGGGGCGAACTTTTATAAAGATTTAGGGA
TTGACCTAGATGACTATACAAATTTAATTGAAAAAGAAATTGACAAAATTAATTCAGTAGAAGGTTCAAATATTACTTAT
GGTCAAAACCTAAGTCCAGATTTGTTCCAAATATTTACTGAAGCAGACAAAATTGCGCAAAAAATGGGCGATGAATACTT
ATCAACTGAGATTATTCTCCTTGCCCTCTTTGAATTAAAACAAAATCCATTGACCAGTTATTTGGTTAGCCATGGACTAA
CAAAAGCAAAAGCGCAAGCTGCAATTGAAAAATTACGCGGAGGTGATAAAGTGACCAGTCAAAATGCAGAAGAAACATAC
AAAGCACTTGAAAAATATGGGGTAGATCTCGTTGCTCAAGTTAAATCAGGTAAACAAGATCCTGTCATTGGACGTGATGA
AGAAATTCGTGATGTCATTCGAGTGCTTTCTCGTAAAACAAAAAATAACCCCGTTCTTATTGGTGAACCTGGGGTTGGTA
AAACAGCCATTGTTGAAGGATTGGCACAAAGGATTGTCAGAAAAGACGTTCCTGAAAATCTGAAAGATAAAACAATCTTT
TCACTTGATATGGGTGCCCTGATTGCAGGAGCGAAATATCGTGGTGAATTTGAAGAACGTTTGAAAGCAGTCCTTAATGA
AGTGAAAAAATCAGATGGACAAATTATCCTCTTTATTGATGAACTTCATACGATTGTTGGTGCAGGTAAAACAGAAGGTT
CAATGGACGCTGGGAACCTTTTAAAACCAATGCTTGCACGTGGTGAACTCCATTTGATTGGGGCAACTACCTTGGATGAA
TATCGTAAATACATGGAAACAGATAAAGCACTTGAACGTCGTTTCCAAAAGGTATTGGTTACTGAACCTACTGTTGAAGA
TACAATTTCAATCTTGCGTGGTCTAAAAGAACGTTTTGAAATTCACCATGGAGTGACCATTCATGATAATGCTTTAGTCG
CAGCAGCAACCCTTTCAAATCGTTATATTACTGACCGATTTTTACCAGATAAAGCCATTGACTTGGTTGATGAAGCCAGT
GCAACAATTCGTGTAGAAATGAATTCACTCCCAACTGAACTTGACCAAGCTAATCGTCGCTTGATGCAATTAGAAATTGA
AGAAGCGGCCCTCAAAAAAGAACGAGATGATGCTTCTAAGAAACGTCTTGAAATTATACGTGGTGAAATTGCTGAACTTC
GAGAAGAAAATAATCAACTCAAAGCTCAATGGGAAGCTGAGAAAAAAGAAGTGGGCAATATTTCTGAAAAACGAAATGAA
TTAGAACATGCTCGCCACGAATTGGAAGAAGCTCAAAATGAAGGAAACTTAGAAAAAGCAGCAGCCCTTCGTTATGGTAA
AATTCCTGAAATTGAAAAAGAACTCAAAGCTATTGAAGAAAAAGCAAAATCAGATGATTTATCCTTAGTTCAAGAATCAG
TCACTGAAGAACAAATCACTGAAGTTGTTGGACGCATGACAGGTATTCCAATTACCAAATTGGTTGAAGGTGAACGTGAA
AAATTACTTCACTTGCCAGAAACACTGCATCAAAGGGTCGTTGGACAAGATGAAGCTGTTGAAGCCGTATCTGATGCCAT
TATTCGTGCGCGTGCAGGAATTCAAGACCCTAATCGTCCACTTGGCTCATTCCTCTTCCTCGGTCCAACTGGGGTAGGTA
AGACCGAACTCGCGAAAGCTTTGGCTGAAAATCTCTTTGATTCAGAAGAACATATGGTTCGGATTGACATGAGTGAATAT
ATGGAAAAACACTCAGTTTCTCGGTTAGTCGGAGCACCTCCAGGATATGTCGGTTACGATGAAGGAGGCCAATTGACTGA
AGCTGTTCGTCGTAATCCTTATACAATCATCTTGCTTGATGAAATCGAAAAAGCACATCCAGATGTCTTCAATATCTTGT
TGCAAGTTTTGGATGACGGCCGTTTGACTGACTCTAAAGGTGTTCTCGTTGACTTTAAGAACACAGTGTTGATTATGACT
TCAAATGTCGGTTCTCAATATTTGCTTGATAATGTTGGAGAAAATGGTGAAATTTCGGAAGAAACAACTGAAAACGTGAT
GTCTCAACTTCGGGCACATTTCAAACCAGAATTTCTAAATCGAATTGATGATACCATTCTTTTCAAACCATTGGCACTTG
AGGATATTAAGAATATTATCGTTAAAATGACTAGCCAACTTTCACATCGTCTTGAAGAAATGGATGTTCAACTTGAGTTG
AGTGAAGAAGTAAAAGTTTGGATTGCCGAAAATGCTTATGAACCAGCTTATGGTGCACGTCCACTCAAACGTTATTTGAC
AAAAGTCATCGAAAATCCATTAGCTAAGCTGATTATCGGAGGAAAAATTCCACCAAAATCAAAAGTTATTGTAACGCTTG
TAGAAAACAAGATTGACTTTGATATTCAAACGATTGCTGAATAA

Upstream 100 bases:

>100_bases
CAAAAAGTTTGACCATTACTGACCAAAGTATTATAATTAGAATGTAGTGAGAAAAAGATAATAATCACTACTAACTATGA
AATCGAAATGAGGTGTTTTT

Downstream 100 bases:

>100_bases
ATAGAAAAAAACCGTTAGCTGATGCTGGCGGTTTTTTATATTTGATAGACAATTACAGTTGAAATGATTTGTTATTTCCG
AACGATTCAATCGAAAAGTT

Product: ClpB protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 867; Mature: 867

Protein sequence:

>867_residues
MDIEKMTTTMQEALGSAQQIAQVRHHQVIEVPHLWRIFVQPNSFGANFYKDLGIDLDDYTNLIEKEIDKINSVEGSNITY
GQNLSPDLFQIFTEADKIAQKMGDEYLSTEIILLALFELKQNPLTSYLVSHGLTKAKAQAAIEKLRGGDKVTSQNAEETY
KALEKYGVDLVAQVKSGKQDPVIGRDEEIRDVIRVLSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPENLKDKTIF
SLDMGALIAGAKYRGEFEERLKAVLNEVKKSDGQIILFIDELHTIVGAGKTEGSMDAGNLLKPMLARGELHLIGATTLDE
YRKYMETDKALERRFQKVLVTEPTVEDTISILRGLKERFEIHHGVTIHDNALVAAATLSNRYITDRFLPDKAIDLVDEAS
ATIRVEMNSLPTELDQANRRLMQLEIEEAALKKERDDASKKRLEIIRGEIAELREENNQLKAQWEAEKKEVGNISEKRNE
LEHARHELEEAQNEGNLEKAAALRYGKIPEIEKELKAIEEKAKSDDLSLVQESVTEEQITEVVGRMTGIPITKLVEGERE
KLLHLPETLHQRVVGQDEAVEAVSDAIIRARAGIQDPNRPLGSFLFLGPTGVGKTELAKALAENLFDSEEHMVRIDMSEY
MEKHSVSRLVGAPPGYVGYDEGGQLTEAVRRNPYTIILLDEIEKAHPDVFNILLQVLDDGRLTDSKGVLVDFKNTVLIMT
SNVGSQYLLDNVGENGEISEETTENVMSQLRAHFKPEFLNRIDDTILFKPLALEDIKNIIVKMTSQLSHRLEEMDVQLEL
SEEVKVWIAENAYEPAYGARPLKRYLTKVIENPLAKLIIGGKIPPKSKVIVTLVENKIDFDIQTIAE

Sequences:

>Translated_867_residues
MDIEKMTTTMQEALGSAQQIAQVRHHQVIEVPHLWRIFVQPNSFGANFYKDLGIDLDDYTNLIEKEIDKINSVEGSNITY
GQNLSPDLFQIFTEADKIAQKMGDEYLSTEIILLALFELKQNPLTSYLVSHGLTKAKAQAAIEKLRGGDKVTSQNAEETY
KALEKYGVDLVAQVKSGKQDPVIGRDEEIRDVIRVLSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPENLKDKTIF
SLDMGALIAGAKYRGEFEERLKAVLNEVKKSDGQIILFIDELHTIVGAGKTEGSMDAGNLLKPMLARGELHLIGATTLDE
YRKYMETDKALERRFQKVLVTEPTVEDTISILRGLKERFEIHHGVTIHDNALVAAATLSNRYITDRFLPDKAIDLVDEAS
ATIRVEMNSLPTELDQANRRLMQLEIEEAALKKERDDASKKRLEIIRGEIAELREENNQLKAQWEAEKKEVGNISEKRNE
LEHARHELEEAQNEGNLEKAAALRYGKIPEIEKELKAIEEKAKSDDLSLVQESVTEEQITEVVGRMTGIPITKLVEGERE
KLLHLPETLHQRVVGQDEAVEAVSDAIIRARAGIQDPNRPLGSFLFLGPTGVGKTELAKALAENLFDSEEHMVRIDMSEY
MEKHSVSRLVGAPPGYVGYDEGGQLTEAVRRNPYTIILLDEIEKAHPDVFNILLQVLDDGRLTDSKGVLVDFKNTVLIMT
SNVGSQYLLDNVGENGEISEETTENVMSQLRAHFKPEFLNRIDDTILFKPLALEDIKNIIVKMTSQLSHRLEEMDVQLEL
SEEVKVWIAENAYEPAYGARPLKRYLTKVIENPLAKLIIGGKIPPKSKVIVTLVENKIDFDIQTIAE
>Mature_867_residues
MDIEKMTTTMQEALGSAQQIAQVRHHQVIEVPHLWRIFVQPNSFGANFYKDLGIDLDDYTNLIEKEIDKINSVEGSNITY
GQNLSPDLFQIFTEADKIAQKMGDEYLSTEIILLALFELKQNPLTSYLVSHGLTKAKAQAAIEKLRGGDKVTSQNAEETY
KALEKYGVDLVAQVKSGKQDPVIGRDEEIRDVIRVLSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPENLKDKTIF
SLDMGALIAGAKYRGEFEERLKAVLNEVKKSDGQIILFIDELHTIVGAGKTEGSMDAGNLLKPMLARGELHLIGATTLDE
YRKYMETDKALERRFQKVLVTEPTVEDTISILRGLKERFEIHHGVTIHDNALVAAATLSNRYITDRFLPDKAIDLVDEAS
ATIRVEMNSLPTELDQANRRLMQLEIEEAALKKERDDASKKRLEIIRGEIAELREENNQLKAQWEAEKKEVGNISEKRNE
LEHARHELEEAQNEGNLEKAAALRYGKIPEIEKELKAIEEKAKSDDLSLVQESVTEEQITEVVGRMTGIPITKLVEGERE
KLLHLPETLHQRVVGQDEAVEAVSDAIIRARAGIQDPNRPLGSFLFLGPTGVGKTELAKALAENLFDSEEHMVRIDMSEY
MEKHSVSRLVGAPPGYVGYDEGGQLTEAVRRNPYTIILLDEIEKAHPDVFNILLQVLDDGRLTDSKGVLVDFKNTVLIMT
SNVGSQYLLDNVGENGEISEETTENVMSQLRAHFKPEFLNRIDDTILFKPLALEDIKNIIVKMTSQLSHRLEEMDVQLEL
SEEVKVWIAENAYEPAYGARPLKRYLTKVIENPLAKLIIGGKIPPKSKVIVTLVENKIDFDIQTIAE

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=38.1270903010033, Blast_Score=194, Evalue=3e-49,
Organism=Escherichia coli, GI1788943, Length=861, Percent_Identity=54.2392566782811, Blast_Score=926, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=358, Percent_Identity=41.8994413407821, Blast_Score=282, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=706, Percent_Identity=52.1246458923513, Blast_Score=754, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=864, Percent_Identity=41.4351851851852, Blast_Score=635, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_LACLA (Q9CFF3)

Other databases:

- EMBL:   AE005176
- PIR:   E86815
- RefSeq:   NP_267681.1
- ProteinModelPortal:   Q9CFF3
- GeneID:   1115182
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L166407
- NMPDR:   fig|272623.1.peg.1566
- HOGENOM:   HBG413133
- OMA:   NSLARMI
- ProtClustDB:   CLSK697783
- BioCyc:   LLAC272623:L166407-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR03346

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 97336; Mature: 97336

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIEKMTTTMQEALGSAQQIAQVRHHQVIEVPHLWRIFVQPNSFGANFYKDLGIDLDDYT
CCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCCCHHHHH
NLIEKEIDKINSVEGSNITYGQNLSPDLFQIFTEADKIAQKMGDEYLSTEIILLALFELK
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
QNPLTSYLVSHGLTKAKAQAAIEKLRGGDKVTSQNAEETYKALEKYGVDLVAQVKSGKQD
CCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCC
PVIGRDEEIRDVIRVLSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPENLKDKTIF
CCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEE
SLDMGALIAGAKYRGEFEERLKAVLNEVKKSDGQIILFIDELHTIVGAGKTEGSMDAGNL
EECHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCHHHH
LKPMLARGELHLIGATTLDEYRKYMETDKALERRFQKVLVTEPTVEDTISILRGLKERFE
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IHHGVTIHDNALVAAATLSNRYITDRFLPDKAIDLVDEASATIRVEMNSLPTELDQANRR
HHCCEEEECCCEEEEEHHCCCCHHHHCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
LMQLEIEEAALKKERDDASKKRLEIIRGEIAELREENNQLKAQWEAEKKEVGNISEKRNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHH
LEHARHELEEAQNEGNLEKAAALRYGKIPEIEKELKAIEEKAKSDDLSLVQESVTEEQIT
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EVVGRMTGIPITKLVEGEREKLLHLPETLHQRVVGQDEAVEAVSDAIIRARAGIQDPNRP
HHHHHHCCCCHHHHHCCHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
LGSFLFLGPTGVGKTELAKALAENLFDSEEHMVRIDMSEYMEKHSVSRLVGAPPGYVGYD
CCCEEEECCCCCCHHHHHHHHHHHHCCCCHHEEEECHHHHHHHHHHHHHHCCCCCCCCCC
EGGQLTEAVRRNPYTIILLDEIEKAHPDVFNILLQVLDDGRLTDSKGVLVDFKNTVLIMT
CCCHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEE
SNVGSQYLLDNVGENGEISEETTENVMSQLRAHFKPEFLNRIDDTILFKPLALEDIKNII
CCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
VKMTSQLSHRLEEMDVQLELSEEVKVWIAENAYEPAYGARPLKRYLTKVIENPLAKLIIG
HHHHHHHHHHHHHHCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCHHHHHHCC
GKIPPKSKVIVTLVENKIDFDIQTIAE
CCCCCCCCEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MDIEKMTTTMQEALGSAQQIAQVRHHQVIEVPHLWRIFVQPNSFGANFYKDLGIDLDDYT
CCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCCCHHHHH
NLIEKEIDKINSVEGSNITYGQNLSPDLFQIFTEADKIAQKMGDEYLSTEIILLALFELK
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
QNPLTSYLVSHGLTKAKAQAAIEKLRGGDKVTSQNAEETYKALEKYGVDLVAQVKSGKQD
CCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCC
PVIGRDEEIRDVIRVLSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRKDVPENLKDKTIF
CCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEE
SLDMGALIAGAKYRGEFEERLKAVLNEVKKSDGQIILFIDELHTIVGAGKTEGSMDAGNL
EECHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCHHHH
LKPMLARGELHLIGATTLDEYRKYMETDKALERRFQKVLVTEPTVEDTISILRGLKERFE
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IHHGVTIHDNALVAAATLSNRYITDRFLPDKAIDLVDEASATIRVEMNSLPTELDQANRR
HHCCEEEECCCEEEEEHHCCCCHHHHCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
LMQLEIEEAALKKERDDASKKRLEIIRGEIAELREENNQLKAQWEAEKKEVGNISEKRNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHH
LEHARHELEEAQNEGNLEKAAALRYGKIPEIEKELKAIEEKAKSDDLSLVQESVTEEQIT
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EVVGRMTGIPITKLVEGEREKLLHLPETLHQRVVGQDEAVEAVSDAIIRARAGIQDPNRP
HHHHHHCCCCHHHHHCCHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
LGSFLFLGPTGVGKTELAKALAENLFDSEEHMVRIDMSEYMEKHSVSRLVGAPPGYVGYD
CCCEEEECCCCCCHHHHHHHHHHHHCCCCHHEEEECHHHHHHHHHHHHHHCCCCCCCCCC
EGGQLTEAVRRNPYTIILLDEIEKAHPDVFNILLQVLDDGRLTDSKGVLVDFKNTVLIMT
CCCHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEE
SNVGSQYLLDNVGENGEISEETTENVMSQLRAHFKPEFLNRIDDTILFKPLALEDIKNII
CCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
VKMTSQLSHRLEEMDVQLELSEEVKVWIAENAYEPAYGARPLKRYLTKVIENPLAKLIIG
HHHHHHHHHHHHHHCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCHHHHHHCC
GKIPPKSKVIVTLVENKIDFDIQTIAE
CCCCCCCCEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471