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The map label for this gene is pdp

Identifier: 15673424

GI number: 15673424

Start: 1464428

End: 1465720

Strand: Reverse

Name: pdp

Synonym: L64175

Alternate gene names: 15673424

Gene position: 1465720-1464428 (Counterclockwise)

Preceding gene: 15673425

Following gene: 15673423

Centisome position: 61.96

GC content: 39.13

Gene sequence:

>1293_bases
ATGACCTATCGGATGGTTGATCTCATTCAAAAGAAAAGAGATAGTGGTGAATTTAGCCAAGCTGAAATCGATTGGATGAT
TGAAAATTATGTCAAAGGAATCGTGCCAGACTATCAAATGTCAGCACTTGCGATGGCAATTTATTTTAAAGGGATGACAA
CAGTAGAAACTGCTTATCTCACGATGGCAATGGTTCATTCAGGAAAAGAATTTGATTTGACTGATATTTCCGGAATCAAG
GTTGATAAACATTCTACTGGTGGAGTGGGCGATAAAGTAACACTTATTTTAGCTCCGCTTGTAGCGTCATTTGGGGTTCC
TGTTGCGAAAATGTCTGGTCGTGGGCTTGGACATACGGGAGGAACTTTGGACAAATTGGAGTCAATTCCTGGCTTCAAAT
TTGAAAAAACGGAAAAAGAATTTATTGATCAGGTCAAAGAAACAGGAATTGCCATAATTGGGCAATCCGATGAACTTGTT
AAAGCCGATAAATTACTCTATGCTCTTCGAGATGTCACAGCAACTGTTGATATTATTCCTCTAATTGCTAGTTCTGTCAT
GTCCAAAAAAATTGCCGCAGGCTCTGACGCCATTCTACTAGATGTAACTGTAGGAGATGGGGCTTTTATGAAGTCAGTTG
AAGATGCTCGCCTTCTCGCTCAAACAATGGTTGACCTTGGTAAATCCATAGGACGAGAAACCGTCGCTGTCATCACAAAT
ATGAGTCAGCCTCTTGGTTTTGCTATCGGAAATCGAAATGAAATGACTGAAGCAGTTCATACTCTACAAGGAAAAGCGCC
AAAGGAATTCCAAGAATTTATTGCGGAACTTGCCCAAATTATGCTGCAACTTGCGGGACTTGAAAAATCAATTCCTGAAA
TTTTAGAGCATTTTACTAATGGTTTAGCTTACGGAAAATTTGTTGAAATGGTCAAGGCCCAAGGTGGTGACCCAACTGCC
TTTGACTATTTGACAGCTCCTCTTCAAGTAAAATACCAAGTGGAAATTAAAGCAGATAAATCAGGATTTATTAGTGAAGA
AAAAGCCTTAGGAATTGGTCTTCTTGCTATGAAATTAGGAGCAGGACGTGCAACTAAGACTGATGATATTGATTTTGAAG
CAGGTGTTACTCTGACGAAAAAGGTAGGAGATAAGGTGAGTGCCGGTGAAGTCATTGCTCAGCTTTATTCCAACCGCGAA
ATTCCTGACGAATTAGTTACTGAATTTAATGACAGTTTGGTCATTAGTGATCAACAAGTTCATCAAAAAGAAATTCTAGA
AATTATCAGATAA

Upstream 100 bases:

>100_bases
ATTTGGTAATTGTCAGCTTGTAGCCAGAGATAAAGGATACTTTATTTTAAGAAGTTATAAAAATATATAATTATTGATAA
GATAAAACGAGGAGGAGCCT

Downstream 100 bases:

>100_bases
GATGAAAAATGATTTAAAAATCCCAACACCTGTTATGGCCCTGCAAGTTATCTTGTCAGCTTTGGCTGGAGCAGCGACCA
AATTGTACTTACAAAATTTT

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTYRMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHSGKEFDLTDISGIK
VDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELV
KADKLLYALRDVTATVDIIPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITN
MSQPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPEILEHFTNGLAYGKFVEMVKAQGGDPTA
FDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE
IPDELVTEFNDSLVISDQQVHQKEILEIIR

Sequences:

>Translated_430_residues
MTYRMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHSGKEFDLTDISGIK
VDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELV
KADKLLYALRDVTATVDIIPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITN
MSQPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPEILEHFTNGLAYGKFVEMVKAQGGDPTA
FDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE
IPDELVTEFNDSLVISDQQVHQKEILEIIR
>Mature_429_residues
TYRMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHSGKEFDLTDISGIKV
DKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVK
ADKLLYALRDVTATVDIIPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNM
SQPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPEILEHFTNGLAYGKFVEMVKAQGGDPTAF
DYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREI
PDELVTEFNDSLVISDQQVHQKEILEIIR

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=432, Percent_Identity=37.2685185185185, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI4503445, Length=432, Percent_Identity=37.2685185185185, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI166158922, Length=432, Percent_Identity=37.2685185185185, Blast_Score=267, Evalue=2e-71,
Organism=Escherichia coli, GI1790842, Length=406, Percent_Identity=40.8866995073892, Blast_Score=270, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46688; Mature: 46556

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYL
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHH
TMAMVHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTG
HHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
GTLDKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIP
CCHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITN
HHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHC
MSQPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPEILEHFTN
CCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKLG
CCHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHC
AGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLVISDQQV
CCCCCCCCCCCCCCCCEEHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEECHHHH
HQKEILEIIR
HHHHHHHHHC
>Mature Secondary Structure 
TYRMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYL
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHH
TMAMVHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTG
HHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
GTLDKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIP
CCHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITN
HHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHC
MSQPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPEILEHFTN
CCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKLG
CCHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHC
AGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLVISDQQV
CCCCCCCCCCCCCCCCEEHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEECHHHH
HQKEILEIIR
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]