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The map label for this gene is ipd

Identifier: 15673286

GI number: 15673286

Start: 1338895

End: 1340268

Strand: Reverse

Name: ipd

Synonym: L138640

Alternate gene names: 15673286

Gene position: 1340268-1338895 (Counterclockwise)

Preceding gene: 15673289

Following gene: 15673284

Centisome position: 56.66

GC content: 35.88

Gene sequence:

>1374_bases
ATGTATACAGTAGGAGATTACCTATTAGACCGATTACACGAGTTAGGAATTGAAGAAATTTTTGGAGTCCCTGGAGACTA
TAACTTACAATTTTTAGATCAAATTATTTCCCGCAAGGATATGAAATGGGTCGGAAATGCTAATGAATTAAATGCTTCAT
ATATGGCTGATGGCTATGCTCGTACTAAAAAAGCTGCCGCATTTCTTACAACCTTTGGAGTAGGTGAATTGAGTGCAGTT
AATGGATTAGCAGGAAGTTACGCCGAAAATTTACCAGTAGTAGAAATAGTGGGATCACCTACATCAAAAGTTCAAAATGA
AGGAAAATTTGTTCATCATACGCTGGCTGACGGTGATTTTAAACACTTTATGAAAATGCACGAACCTGTTACAGCAGCTC
GAACTTTACTGACAGCAGAAAATGCAACCGTTGAAATTGATCGAGTACTTTCTGCACTACTAAAAGAAAGAAAACCTGTC
TATATCAACTTACCAGTTGATGTTGCTGCTGCAAAAGCAGAGAAACCCTCACTCCCTTTGAAAAAAGAAAATCCAACTTC
AAATACAAGTGACCAAGAAATTTTGAACAAAATTCAAGAAAGCTTGAAAAATGCCAAAAAACCAATCGTGATTACAGGAC
ATGAAATAATTAGTTTTGGCTTAGAAAAAACAGTCACTCAATTTATTTCAAAGACAAAACTCCCTATTACGACATTAAAC
TTTGGAAAAAGTTCAGTTGATGAAACTCTCCCTTCATTTTTAGGAATCTATAATGGTAAACTCTCAGAACCTAATCTTAA
AGAATTCGTGGAATCAGCCGACTTCATCCTGATGCTTGGAGTTAAACTCACAGACTCTTCAACAGGAGCCTTCACTCATC
ATTTAAATGAAAATAAAATGATTTCACTGAATATAAATGAAGGAAAAATATTTAACGAAAGAATCCAAAATTTTGATTTT
GAATCCCTCATCTCCTCTCTCTTAGACCTAAGCGGAATAGAATACAAAGGAAAATATATCGATAAAAAGCAAGAAGACTT
TGTTCCATCAAATGCGCTTTTATCACAAGACCGCCTATGGCAAGCAGTTGAAAACCTAACTCAAAGCAATGAAACAATCG
TTGCTGAACAAGGGACATCATTCTTTGGCGCTTCATCAATTTTCTTAAAACCAAAGAGTCATTTTATTGGTCAACCCTTA
TGGGGATCAATTGGATATACATTCCCAGCAGCATTAGGAAGCCAAATTGCAGATAAAGAAAGCAGACACCTTTTATTTAT
TGGTGATGGTTCACTTCAACTTACAGTGCAAGAACGCAAATTGCAAGTCCAAGTTAGCCAGCCAAGCTCATCTCATATGA
ACTCTTATAGTTGA

Upstream 100 bases:

>100_bases
AATTTAAATAAGTCAATATCGTTGACTTATTTAAAGAAAAGCGTTATTCTACAAATGTCAAGTTGATTGACCAATATATA
ATAAAATATGGAGGAATGCG

Downstream 100 bases:

>100_bases
ACATTTTTCTTGGATAATGGTTCATCCAATACTCGATAGCGGCGACTTCTTCAGGGGTCGTCTTTGTTGTGCCTTTTGGC
AGATGCCTACGAATCATTCG

Product: indole-3-pyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISRKDMKWVGNANELNASYMADGYARTKKAAAFLTTFGVGELSAV
NGLAGSYAENLPVVEIVGSPTSKVQNEGKFVHHTLADGDFKHFMKMHEPVTAARTLLTAENATVEIDRVLSALLKERKPV
YINLPVDVAAAKAEKPSLPLKKENPTSNTSDQEILNKIQESLKNAKKPIVITGHEIISFGLEKTVTQFISKTKLPITTLN
FGKSSVDETLPSFLGIYNGKLSEPNLKEFVESADFILMLGVKLTDSSTGAFTHHLNENKMISLNINEGKIFNERIQNFDF
ESLISSLLDLSGIEYKGKYIDKKQEDFVPSNALLSQDRLWQAVENLTQSNETIVAEQGTSFFGASSIFLKPKSHFIGQPL
WGSIGYTFPAALGSQIADKESRHLLFIGDGSLQLTVQERKLQVQVSQPSSSHMNSYS

Sequences:

>Translated_457_residues
MYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISRKDMKWVGNANELNASYMADGYARTKKAAAFLTTFGVGELSAV
NGLAGSYAENLPVVEIVGSPTSKVQNEGKFVHHTLADGDFKHFMKMHEPVTAARTLLTAENATVEIDRVLSALLKERKPV
YINLPVDVAAAKAEKPSLPLKKENPTSNTSDQEILNKIQESLKNAKKPIVITGHEIISFGLEKTVTQFISKTKLPITTLN
FGKSSVDETLPSFLGIYNGKLSEPNLKEFVESADFILMLGVKLTDSSTGAFTHHLNENKMISLNINEGKIFNERIQNFDF
ESLISSLLDLSGIEYKGKYIDKKQEDFVPSNALLSQDRLWQAVENLTQSNETIVAEQGTSFFGASSIFLKPKSHFIGQPL
WGSIGYTFPAALGSQIADKESRHLLFIGDGSLQLTVQERKLQVQVSQPSSSHMNSYS
>Mature_457_residues
MYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISRKDMKWVGNANELNASYMADGYARTKKAAAFLTTFGVGELSAV
NGLAGSYAENLPVVEIVGSPTSKVQNEGKFVHHTLADGDFKHFMKMHEPVTAARTLLTAENATVEIDRVLSALLKERKPV
YINLPVDVAAAKAEKPSLPLKKENPTSNTSDQEILNKIQESLKNAKKPIVITGHEIISFGLEKTVTQFISKTKLPITTLN
FGKSSVDETLPSFLGIYNGKLSEPNLKEFVESADFILMLGVKLTDSSTGAFTHHLNENKMISLNINEGKIFNERIQNFDF
ESLISSLLDLSGIEYKGKYIDKKQEDFVPSNALLSQDRLWQAVENLTQSNETIVAEQGTSFFGASSIFLKPKSHFIGQPL
WGSIGYTFPAALGSQIADKESRHLLFIGDGSLQLTVQERKLQVQVSQPSSSHMNSYS

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=484, Percent_Identity=23.3471074380165, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790104, Length=458, Percent_Identity=22.4890829694323, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787096, Length=471, Percent_Identity=23.3545647558386, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531299, Length=280, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531301, Length=280, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323073, Length=453, Percent_Identity=37.7483443708609, Blast_Score=297, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323163, Length=452, Percent_Identity=37.1681415929204, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6321524, Length=453, Percent_Identity=37.3068432671082, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6320123, Length=460, Percent_Identity=33.4782608695652, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6320588, Length=504, Percent_Identity=29.3650793650794, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6323755, Length=490, Percent_Identity=22.8571428571429, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922626, Length=322, Percent_Identity=24.5341614906832, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 50518; Mature: 50518

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISRKDMKWVGNANELNASYMADGYA
CCCHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCHH
RTKKAAAFLTTFGVGELSAVNGLAGSYAENLPVVEIVGSPTSKVQNEGKFVHHTLADGDF
HHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCHHHHHCCCCEEEEECCCCHH
KHFMKMHEPVTAARTLLTAENATVEIDRVLSALLKERKPVYINLPVDVAAAKAEKPSLPL
HHHHHHHCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCCC
KKENPTSNTSDQEILNKIQESLKNAKKPIVITGHEIISFGLEKTVTQFISKTKLPITTLN
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEC
FGKSSVDETLPSFLGIYNGKLSEPNLKEFVESADFILMLGVKLTDSSTGAFTHHLNENKM
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEEEEECCCCCCEEEECCCCEE
ISLNINEGKIFNERIQNFDFESLISSLLDLSGIEYKGKYIDKKQEDFVPSNALLSQDRLW
EEEECCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHH
QAVENLTQSNETIVAEQGTSFFGASSIFLKPKSHFIGQPLWGSIGYTFPAALGSQIADKE
HHHHHHHCCCCEEEEECCCCCCCCCEEEECCCHHHCCCCCCCCCCCCCHHHHHHHHCCCC
SRHLLFIGDGSLQLTVQERKLQVQVSQPSSSHMNSYS
CCEEEEEECCCEEEEEEEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISRKDMKWVGNANELNASYMADGYA
CCCHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCHH
RTKKAAAFLTTFGVGELSAVNGLAGSYAENLPVVEIVGSPTSKVQNEGKFVHHTLADGDF
HHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCHHHHHCCCCEEEEECCCCHH
KHFMKMHEPVTAARTLLTAENATVEIDRVLSALLKERKPVYINLPVDVAAAKAEKPSLPL
HHHHHHHCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCCC
KKENPTSNTSDQEILNKIQESLKNAKKPIVITGHEIISFGLEKTVTQFISKTKLPITTLN
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEC
FGKSSVDETLPSFLGIYNGKLSEPNLKEFVESADFILMLGVKLTDSSTGAFTHHLNENKM
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEEEEECCCCCCEEEECCCCEE
ISLNINEGKIFNERIQNFDFESLISSLLDLSGIEYKGKYIDKKQEDFVPSNALLSQDRLW
EEEECCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHH
QAVENLTQSNETIVAEQGTSFFGASSIFLKPKSHFIGQPLWGSIGYTFPAALGSQIADKE
HHHHHHHCCCCEEEEECCCCCCCCCEEEECCCHHHCCCCCCCCCCCCCHHHHHHHHCCCC
SRHLLFIGDGSLQLTVQERKLQVQVSQPSSSHMNSYS
CCEEEEEECCCEEEEEEEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]