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The map label for this gene is icd

Identifier: 15672654

GI number: 15672654

Start: 671070

End: 672308

Strand: Direct

Name: icd

Synonym: L71075

Alternate gene names: 15672654

Gene position: 671070-672308 (Clockwise)

Preceding gene: 15672653

Following gene: 15672656

Centisome position: 28.37

GC content: 33.49

Gene sequence:

>1239_bases
ATGAAAATTGAGATGAAAAATGGAAAATTAGTTGTGCCAGATTATCCAGCAATTGGTTATATTAGAGGAGATGGTGTTGG
CGAAGATATTTTTCCTCAGGCGCAAAAAGTTTTTGATGCTGCGGTTCTAAAAATTTATGGTCAAAAAAAGAAAATAGAAT
GGCAAAAATTATTGGCAGGAGGAGAAGCATTTGAGACTTGTGGAGAATATCTGCCCAAAGAAACTCTCGCTCATATTAAT
GAAAATTTAATTGCGATAAAGGGACCACTAATGACCCCGGTCGGTGAAAGCTTTCGTTCAATTAATGTTACTTTAAGACA
AAAAATGGATTTATATGCTTGCGTAAGACCAGTTGAATATTTTAAAGGGATAAAATCCCCAGTTAAGGCGCCAGAAAAAG
TTGACATGACAATTTTTCGAGAAAATACAGAAGATATTTATGCAGGTATTGAATTTGCTAGTGAAACAAATGAGTCTCAC
AACTTATTAAAATTTTTAGAAAAAGAATTGAATGTCCATTCTATTCGCTTTCCAAAAACTTCAGCACTAGGAATAAAACC
TGTTAGTCCTGAAGGAAGTAAACGACTGGTTAATGCGGCTTTTGAGTACGCTCTGAAAATGAACAAAAAAAGAGTGACCT
TTGTTCATAAGGGAAATATTATGAAATTTACTGAAGGAGGATTTAGAAATTGGGCCTATGAGGTTGCTAGGGAATATCCA
ACTTTTACAAAACTAGAATACGATGAAATCAAAAATGAAAGAGGAAGTTTACAAGCTGAAAATGAGAAAAAAGCAGCATT
AAAATCAGGAAAAATTTATGTAGATGATGTAATTGCTGACAACTTCCTCCAACAGATTATTTTAAATCCTGAAAATTTTG
AAGTAATTGCCACTCTTAATTTAAATGGTGATTATATTTCAGATGCACTTGCCGCACAGGTTGGAGGAATTGGAATTGCA
CCAGGAGCGAATATTAATTATAAAAGCGGTCATGCTATTTTTGAAGCAACTCATGGAACAGCTCCAGATATCGCTGGAAA
AAATATAGCAAATCCTTCTAGTCTAATTTTATCTGGAGTGATGATGTTTGAGTATTTAGGCTGGCAAGAGGTAGCTGAAT
TAATCAAAATTGCTCTTTCATTTTCATTCAGGAATGGAAATTTGACAGCTGATTTAGGTGGAAAACTTTCAACTTCAAAA
TTTTCCGACGTTTTAATTGATTTTATAAAAACATATTAA

Upstream 100 bases:

>100_bases
TTTTACGCTTTGATTCTCAGGCGGATTTAGATTACTATGCTAATGACGGTATAATGCCTTATGTGATTCGGAAAAAATAA
AAAAATAGGTGAAAATTATT

Downstream 100 bases:

>100_bases
AAAAATAGATTGATAATCAGAAAAATAAAAAAGCCCTGAAATCAGGGCCTTTAAGATTTACATCATTATTTTAAGGAATT
ATTTTCCATAATTTCATCGA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKIEMKNGKLVVPDYPAIGYIRGDGVGEDIFPQAQKVFDAAVLKIYGQKKKIEWQKLLAGGEAFETCGEYLPKETLAHIN
ENLIAIKGPLMTPVGESFRSINVTLRQKMDLYACVRPVEYFKGIKSPVKAPEKVDMTIFRENTEDIYAGIEFASETNESH
NLLKFLEKELNVHSIRFPKTSALGIKPVSPEGSKRLVNAAFEYALKMNKKRVTFVHKGNIMKFTEGGFRNWAYEVAREYP
TFTKLEYDEIKNERGSLQAENEKKAALKSGKIYVDDVIADNFLQQIILNPENFEVIATLNLNGDYISDALAAQVGGIGIA
PGANINYKSGHAIFEATHGTAPDIAGKNIANPSSLILSGVMMFEYLGWQEVAELIKIALSFSFRNGNLTADLGGKLSTSK
FSDVLIDFIKTY

Sequences:

>Translated_412_residues
MKIEMKNGKLVVPDYPAIGYIRGDGVGEDIFPQAQKVFDAAVLKIYGQKKKIEWQKLLAGGEAFETCGEYLPKETLAHIN
ENLIAIKGPLMTPVGESFRSINVTLRQKMDLYACVRPVEYFKGIKSPVKAPEKVDMTIFRENTEDIYAGIEFASETNESH
NLLKFLEKELNVHSIRFPKTSALGIKPVSPEGSKRLVNAAFEYALKMNKKRVTFVHKGNIMKFTEGGFRNWAYEVAREYP
TFTKLEYDEIKNERGSLQAENEKKAALKSGKIYVDDVIADNFLQQIILNPENFEVIATLNLNGDYISDALAAQVGGIGIA
PGANINYKSGHAIFEATHGTAPDIAGKNIANPSSLILSGVMMFEYLGWQEVAELIKIALSFSFRNGNLTADLGGKLSTSK
FSDVLIDFIKTY
>Mature_412_residues
MKIEMKNGKLVVPDYPAIGYIRGDGVGEDIFPQAQKVFDAAVLKIYGQKKKIEWQKLLAGGEAFETCGEYLPKETLAHIN
ENLIAIKGPLMTPVGESFRSINVTLRQKMDLYACVRPVEYFKGIKSPVKAPEKVDMTIFRENTEDIYAGIEFASETNESH
NLLKFLEKELNVHSIRFPKTSALGIKPVSPEGSKRLVNAAFEYALKMNKKRVTFVHKGNIMKFTEGGFRNWAYEVAREYP
TFTKLEYDEIKNERGSLQAENEKKAALKSGKIYVDDVIADNFLQQIILNPENFEVIATLNLNGDYISDALAAQVGGIGIA
PGANINYKSGHAIFEATHGTAPDIAGKNIANPSSLILSGVMMFEYLGWQEVAELIKIALSFSFRNGNLTADLGGKLSTSK
FSDVLIDFIKTY

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=394, Percent_Identity=33.248730964467, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI4758582, Length=397, Percent_Identity=29.2191435768262, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI28178821, Length=395, Percent_Identity=29.620253164557, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI28178816, Length=395, Percent_Identity=29.1139240506329, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI28178838, Length=374, Percent_Identity=28.8770053475936, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI28178819, Length=230, Percent_Identity=32.1739130434783, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1787381, Length=416, Percent_Identity=51.2019230769231, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788101, Length=404, Percent_Identity=28.7128712871287, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI87081683, Length=408, Percent_Identity=26.4705882352941, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=32.5641025641026, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144293, Length=392, Percent_Identity=29.0816326530612, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17550882, Length=400, Percent_Identity=26.75, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=392, Percent_Identity=28.8265306122449, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324709, Length=394, Percent_Identity=33.502538071066, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6322097, Length=394, Percent_Identity=32.741116751269, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324291, Length=399, Percent_Identity=29.8245614035088, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319830, Length=408, Percent_Identity=24.2647058823529, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643270, Length=392, Percent_Identity=34.6938775510204, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24643268, Length=392, Percent_Identity=34.6938775510204, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24661184, Length=395, Percent_Identity=32.1518987341772, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI281362242, Length=394, Percent_Identity=29.6954314720812, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24648872, Length=394, Percent_Identity=29.6954314720812, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI161078635, Length=339, Percent_Identity=30.3834808259587, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI161078637, Length=339, Percent_Identity=30.3834808259587, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI161078633, Length=339, Percent_Identity=30.3834808259587, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24650122, Length=339, Percent_Identity=30.3834808259587, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161078639, Length=339, Percent_Identity=30.3834808259587, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20130355, Length=398, Percent_Identity=24.1206030150754, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45789; Mature: 45789

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEMKNGKLVVPDYPAIGYIRGDGVGEDIFPQAQKVFDAAVLKIYGQKKKIEWQKLLAG
CEEEECCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
GEAFETCGEYLPKETLAHINENLIAIKGPLMTPVGESFRSINVTLRQKMDLYACVRPVEY
CHHHHHHHHHCCHHHHHHHCCCEEEEECCCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHH
FKGIKSPVKAPEKVDMTIFRENTEDIYAGIEFASETNESHNLLKFLEKELNVHSIRFPKT
HHCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCC
SALGIKPVSPEGSKRLVNAAFEYALKMNKKRVTFVHKGNIMKFTEGGFRNWAYEVAREYP
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHCC
TFTKLEYDEIKNERGSLQAENEKKAALKSGKIYVDDVIADNFLQQIILNPENFEVIATLN
CCCCEEHHHHCCCCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDALAAQVGGIGIAPGANINYKSGHAIFEATHGTAPDIAGKNIANPSSLILSGV
CCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
MMFEYLGWQEVAELIKIALSFSFRNGNLTADLGGKLSTSKFSDVLIDFIKTY
HHHHHCCHHHHHHHHHHHHHEEECCCCEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIEMKNGKLVVPDYPAIGYIRGDGVGEDIFPQAQKVFDAAVLKIYGQKKKIEWQKLLAG
CEEEECCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
GEAFETCGEYLPKETLAHINENLIAIKGPLMTPVGESFRSINVTLRQKMDLYACVRPVEY
CHHHHHHHHHCCHHHHHHHCCCEEEEECCCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHH
FKGIKSPVKAPEKVDMTIFRENTEDIYAGIEFASETNESHNLLKFLEKELNVHSIRFPKT
HHCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCC
SALGIKPVSPEGSKRLVNAAFEYALKMNKKRVTFVHKGNIMKFTEGGFRNWAYEVAREYP
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHCC
TFTKLEYDEIKNERGSLQAENEKKAALKSGKIYVDDVIADNFLQQIILNPENFEVIATLN
CCCCEEHHHHCCCCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDALAAQVGGIGIAPGANINYKSGHAIFEATHGTAPDIAGKNIANPSSLILSGV
CCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
MMFEYLGWQEVAELIKIALSFSFRNGNLTADLGGKLSTSKFSDVLIDFIKTY
HHHHHCCHHHHHHHHHHHHHEEECCCCEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA