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The map label for this gene is clpC

Identifier: 15672624

GI number: 15672624

Start: 629799

End: 632249

Strand: Direct

Name: clpC

Synonym: L0222

Alternate gene names: 15672624

Gene position: 629799-632249 (Clockwise)

Preceding gene: 15672623

Following gene: 15672625

Centisome position: 26.62

GC content: 38.31

Gene sequence:

>2451_bases
ATGAAATTTGAAAATATAAAATATACACCAACGCTTGACCGAATTTTAGAAAAAGCGGAAGAGTATGCTCACCAATATCA
ATATGGCACCATTGAAAGTGCTCATTTACTGGCTGCAATGGCAACGACCTCAGGTTCAATTGCATACAGCCTCCTTGCTG
GAATGAATGTTGATTCTTCTGACTTACTGATTGATTTAGAGGATTTATCAAGTCATGTTAAGGTCAAACGTTCAACTTTA
CGTTTTTCACCTCGTGCAGAAGAAGTGATGACTGCGGCAAGTTTTTTAGCAATTCATAATAACTCAGAAGCCGTTGGAAC
AGAACACTTGCTTTATGCCCTACTTCAAGTAGAAGATGGATTTGGTCTTCAACTTCTGAAATTACAAAAAATCAATATTG
TATCTTTGCGAAAAGAGCTTGAGAAAAGAACTGGACTCAAAGTTCCAGAAAGTAAAAAAGCTGTGACTCCAATGTCAAAA
CGCAAGATGGCAAAGGGAGTTGCAGAAAATTCAACGACGCCAACGTTAGACTCTGTATCCTCAGATTTAACCGAAGAAGC
TCGCTTGGGTAAACTTGACCCAATGATTGGACGAGAAGCTGAAATTGACCGTTTGATTCATATTCTCAGCCGCAGAACAA
AAAATAATCCTGTCTTAGTTGGAGAGCCCGGTGTTGGGAAATCAGCAATTATTGAAGGTTTGGCCCAAAGAATTGTCAAT
GGTCAAGTTCCAATTGGTTTGATGAATAGTCGAATTATGGCTTTGAATATGGCGACTGTTGTTGCTGGGACAAAATTTAG
AGGTGAATTTGAGGATCGTTTGACAGCTATTGTTGAAGAAGTTAGCAGTGATCCAGATGTCATTATTTTCATTGATGAAT
TACACACAATCATCGGTGCTGGTGGCGGAATGGATTCTGTCAATGATGCCGCAAATATTTTGAAACCAGCGCTTGCTCGT
GGTGATTTTCAAATGGTCGGAGCAACAACCTATCATGAATATCAAAAATATATTGAAAAAGATGAAGCTTTAGAACGCCG
TTTGGCGAGAATAAATGTTGACGAGCCAAGTCCAGATGAAGCGATTGCTATTTTGCAAGGCTTACGTGAAAAATTTGAAG
ACTATCATCAAGTGAAATTTACTGACCAAGCCATTAAAAGTGCTGTAATGCTCAGTGTTCGTTATATGACTAGCCGAAAA
TTGCCTGACAAAGCCATTGATTTACTTGATGAAGCTGCAGCAGCAGTGAAAATTTCTGTCAAAAATCAACAAACAAAACG
TCTTGATTTAGAAAAAGAATTAACGGAAGCTCAAGAAGAATTATCAGAAGCTGTCATTAAACTTGATATCAAAGCGTCTC
GTACAAAAGAAAAAGCAGTTGAAAAAATTGCTGACAAGATTTATAAATTCTCAGTAAAAGAAGATAAACGTCAAGAAGTT
ACTGACCAAGCTGTTGTTGCTGTTGCCTCAACACTGACAGGTGTTCCAATCACACAAATGACTAAGTCTGAAAGTGATCG
TTTAATCAATCTTGAAAAAGAATTACATAAACGAGTTGTTGGACAAGAAGAAGCTATTTCTGCCGTTTCAAGAGCCATTC
GTCGGGCACGTTCCGGTGTTGCTGACAGCCGTCGTCCAATGGGTTCTTTCATGTTCCTTGGACCAACAGGGGTCGGTAAA
ACCGAACTTGCTAAAGCACTGGCTGACAGTGTGTTTGGTAGTGAAGATAATATGATTCGTGTTGACATGAGTGAATTCAT
GGAAAAACATTCGACTTCACGCTTGATTGGAGCTCCTCCAGGGTATGTAGGTTATGATGAGGGTGGTCAATTGACAGAAC
GCGTTCGTAATAAACCTTATTCTGTTGTTCTTTTAGATGAAGTCGAAAAAGCTCATCCTGACGTTTTCAACATCATGTTG
CAAATTCTAGATGATGGCTTTGTGACTGATACTAAAGGTCGTAAAGTTGATTTCAGAAATACAATTATTATCATGACTTC
AAACTTGGGAGCGACTGCTCTTCGTGATGATAAGACAGTTGGTTTTGGCGCTAAAAATATCACAGCTGATTATTCAGCCA
TGAAATCAAGAATATTAGAAGAGCTTAAACGTCATTATCGTCCTGAGTTTCTTAATCGAATTGATGAAAATATTGTTTTC
CACTCATTGGAAAGTCAAGAGATTGAACAAATTGTTAAAATTATGAGTAAATCTTTGATTAAACGTCTGGCAGAACAAGA
TATTCATGTTAAACTCACACCGTCAGCGGTGAAATTAATTGCTGAGGTAGGTTTTGACCCAGAATATGGTGCACGTCCGC
TCCGCAAGGCTCTTCAAAAAGAAGTTGAAGACCTTTTAAGTGAACAATTGCTCTCTGGTGAAATCAAAGCAGGTAATCAT
GTTTCAATTGGGGCATCTAATAAAAAAATTAAAATCGCTCAAATTGTTTGA

Upstream 100 bases:

>100_bases
GAGGGAAATCTACTTTTGTTAGTCATTACTGACGGAGCCATTAGTCCCTTTACTCGTGGTATAATGATGAAAAGTATAAT
AAACAGATTGGACCGTGACG

Downstream 100 bases:

>100_bases
GATGAAAGCTGTTTCATGTTATAATTAAATTAGAAATAAAGGAAAGGACAGTTCGAAAAGATTCAGAAGTCCTGAAAATT
CCAAAAGTTTAAGGGCTTCA

Product: ATP-dependent protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 816; Mature: 816

Protein sequence:

>816_residues
MKFENIKYTPTLDRILEKAEEYAHQYQYGTIESAHLLAAMATTSGSIAYSLLAGMNVDSSDLLIDLEDLSSHVKVKRSTL
RFSPRAEEVMTAASFLAIHNNSEAVGTEHLLYALLQVEDGFGLQLLKLQKINIVSLRKELEKRTGLKVPESKKAVTPMSK
RKMAKGVAENSTTPTLDSVSSDLTEEARLGKLDPMIGREAEIDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSSDPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVMLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQQTKRLDLEKELTEAQEELSEAVIKLDIKASRTKEKAVEKIADKIYKFSVKEDKRQEV
TDQAVVAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMKSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAVKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
VSIGASNKKIKIAQIV

Sequences:

>Translated_816_residues
MKFENIKYTPTLDRILEKAEEYAHQYQYGTIESAHLLAAMATTSGSIAYSLLAGMNVDSSDLLIDLEDLSSHVKVKRSTL
RFSPRAEEVMTAASFLAIHNNSEAVGTEHLLYALLQVEDGFGLQLLKLQKINIVSLRKELEKRTGLKVPESKKAVTPMSK
RKMAKGVAENSTTPTLDSVSSDLTEEARLGKLDPMIGREAEIDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSSDPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVMLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQQTKRLDLEKELTEAQEELSEAVIKLDIKASRTKEKAVEKIADKIYKFSVKEDKRQEV
TDQAVVAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMKSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAVKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
VSIGASNKKIKIAQIV
>Mature_816_residues
MKFENIKYTPTLDRILEKAEEYAHQYQYGTIESAHLLAAMATTSGSIAYSLLAGMNVDSSDLLIDLEDLSSHVKVKRSTL
RFSPRAEEVMTAASFLAIHNNSEAVGTEHLLYALLQVEDGFGLQLLKLQKINIVSLRKELEKRTGLKVPESKKAVTPMSK
RKMAKGVAENSTTPTLDSVSSDLTEEARLGKLDPMIGREAEIDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSSDPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVMLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQQTKRLDLEKELTEAQEELSEAVIKLDIKASRTKEKAVEKIADKIYKFSVKEDKRQEV
TDQAVVAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMKSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAVKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
VSIGASNKKIKIAQIV

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=308, Percent_Identity=37.3376623376623, Blast_Score=191, Evalue=2e-48,
Organism=Escherichia coli, GI1788943, Length=862, Percent_Identity=42.5754060324826, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=815, Percent_Identity=35.4601226993865, Blast_Score=491, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6320464, Length=706, Percent_Identity=44.1926345609065, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6323002, Length=887, Percent_Identity=36.3021420518602, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 90457; Mature: 90457

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFENIKYTPTLDRILEKAEEYAHQYQYGTIESAHLLAAMATTSGSIAYSLLAGMNVDSS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCC
DLLIDLEDLSSHVKVKRSTLRFSPRAEEVMTAASFLAIHNNSEAVGTEHLLYALLQVEDG
CCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCC
FGLQLLKLQKINIVSLRKELEKRTGLKVPESKKAVTPMSKRKMAKGVAENSTTPTLDSVS
CCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHH
SDLTEEARLGKLDPMIGREAEIDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHC
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSSDPDVIIFIDELHTIIGA
CCCCEEECCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCC
GGGMDSVNDAANILKPALARGDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDE
CCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
AIAILQGLREKFEDYHQVKFTDQAIKSAVMLSVRYMTSRKLPDKAIDLLDEAAAAVKISV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEE
KNQQTKRLDLEKELTEAQEELSEAVIKLDIKASRTKEKAVEKIADKIYKFSVKEDKRQEV
CCCHHHHCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TDQAVVAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGV
HHHHHHHHHHHHCCCCHHHHHCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
ADSRRPMGSFMFLGPTGVGKTELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPP
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCEECCCC
GYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIMLQILDDGFVTDTKGRKVDFRN
CCCCCCCCCHHHHHHCCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCEECCCCCEEECCC
TIIIMTSNLGATALRDDKTVGFGAKNITADYSAMKSRILEELKRHYRPEFLNRIDENIVF
EEEEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHE
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAVKLIAEVGFDPEYGARPLRKALQK
ECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHH
EVEDLLSEQLLSGEIKAGNHVSIGASNKKIKIAQIV
HHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEECC
>Mature Secondary Structure
MKFENIKYTPTLDRILEKAEEYAHQYQYGTIESAHLLAAMATTSGSIAYSLLAGMNVDSS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCC
DLLIDLEDLSSHVKVKRSTLRFSPRAEEVMTAASFLAIHNNSEAVGTEHLLYALLQVEDG
CCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCC
FGLQLLKLQKINIVSLRKELEKRTGLKVPESKKAVTPMSKRKMAKGVAENSTTPTLDSVS
CCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHH
SDLTEEARLGKLDPMIGREAEIDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHC
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSSDPDVIIFIDELHTIIGA
CCCCEEECCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCC
GGGMDSVNDAANILKPALARGDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDE
CCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
AIAILQGLREKFEDYHQVKFTDQAIKSAVMLSVRYMTSRKLPDKAIDLLDEAAAAVKISV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEE
KNQQTKRLDLEKELTEAQEELSEAVIKLDIKASRTKEKAVEKIADKIYKFSVKEDKRQEV
CCCHHHHCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TDQAVVAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGV
HHHHHHHHHHHHCCCCHHHHHCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
ADSRRPMGSFMFLGPTGVGKTELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPP
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCEECCCC
GYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIMLQILDDGFVTDTKGRKVDFRN
CCCCCCCCCHHHHHHCCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCEECCCCCEEECCC
TIIIMTSNLGATALRDDKTVGFGAKNITADYSAMKSRILEELKRHYRPEFLNRIDENIVF
EEEEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHE
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAVKLIAEVGFDPEYGARPLRKALQK
ECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHH
EVEDLLSEQLLSGEIKAGNHVSIGASNKKIKIAQIV
HHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]