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The map label for this gene is dfpA

Identifier: 15672554

GI number: 15672554

Start: 566895

End: 567431

Strand: Reverse

Name: dfpA

Synonym: L166912

Alternate gene names: 15672554

Gene position: 567431-566895 (Counterclockwise)

Preceding gene: 15672555

Following gene: 15672553

Centisome position: 23.99

GC content: 36.69

Gene sequence:

>537_bases
ATGACTAAAATTACACTTGCGGTAACAGGTTCAATTGCAGCTTACAAAGCAGCAGATTTAACTTCTTTACTGACAAAAGA
GGGACATGATGTGACAGTTTTAATGACAAAAAGCGCTACTCAGTTCATCACTCCTTTAACTCTACAAGTTTTGTCCAAAA
ATAAGGTTCACTTGGATATTATGGACGAAGAACGTCCTGAATTGGTTAATCATATTGATTTAGCTAAAAATACTGAGCTT
TTCCTTGTTGCACCTGCAACTGCTGATACAATTAGCCGTTTGGCGCAAGGCCGAGCTGATGATATTGTCACTTCTGTAGC
CCTTGCTCTTGAACCTTCTGTACCAAAATATTTTGCCCCTGCAATGAATACTAAAATGTATCAACATCCTTTGACGCAAA
AAAACATTGAGATTCTTAAGAAAATAGATTATAATATGATTCAACCGAAAAAATCTTTGCTCGCTTGTGGAGATTTTGGT
GAGGGAGCACTCGCCGACTTACCTGATATTCTATCGGATTTAAAAAATTCTTTATAA

Upstream 100 bases:

>100_bases
GACCATCAAGCATTTTTGGTCAGTAAAAATCATGAAATTACTTTAAAAACAAAGGCTGAAATTGCTGACAGACTTTTAAA
AACCTCGGAGGAATTAAAAA

Downstream 100 bases:

>100_bases
AATAAATGAGGTATTTATGAAAAAATCAAAAGCGTCTGATGTGGCAATCTTGTCCATTTTTATTGCAATTATGGTCGTTG
TCCAACTTTTGAGTCAAATT

Product: phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: PPCDC [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MTKITLAVTGSIAAYKAADLTSLLTKEGHDVTVLMTKSATQFITPLTLQVLSKNKVHLDIMDEERPELVNHIDLAKNTEL
FLVAPATADTISRLAQGRADDIVTSVALALEPSVPKYFAPAMNTKMYQHPLTQKNIEILKKIDYNMIQPKKSLLACGDFG
EGALADLPDILSDLKNSL

Sequences:

>Translated_178_residues
MTKITLAVTGSIAAYKAADLTSLLTKEGHDVTVLMTKSATQFITPLTLQVLSKNKVHLDIMDEERPELVNHIDLAKNTEL
FLVAPATADTISRLAQGRADDIVTSVALALEPSVPKYFAPAMNTKMYQHPLTQKNIEILKKIDYNMIQPKKSLLACGDFG
EGALADLPDILSDLKNSL
>Mature_177_residues
TKITLAVTGSIAAYKAADLTSLLTKEGHDVTVLMTKSATQFITPLTLQVLSKNKVHLDIMDEERPELVNHIDLAKNTELF
LVAPATADTISRLAQGRADDIVTSVALALEPSVPKYFAPAMNTKMYQHPLTQKNIEILKKIDYNMIQPKKSLLACGDFGE
GALADLPDILSDLKNSL

Specific function: Catalyzes the decarboxylation of 4'- phosphopantothenoylcysteine to 4'-phosphopantetheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=37.8531073446328, Blast_Score=107, Evalue=7e-24,
Organism=Escherichia coli, GI87082301, Length=164, Percent_Identity=42.0731707317073, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17560194, Length=177, Percent_Identity=38.4180790960452, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322762, Length=190, Percent_Identity=32.1052631578947, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322925, Length=219, Percent_Identity=23.7442922374429, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324629, Length=115, Percent_Identity=27.8260869565217, Blast_Score=61, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24657262, Length=177, Percent_Identity=36.7231638418079, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011847
- InterPro:   IPR003382 [H]

Pfam domain/function: PF02441 Flavoprotein [H]

EC number: =4.1.1.36 [H]

Molecular weight: Translated: 19420; Mature: 19289

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKITLAVTGSIAAYKAADLTSLLTKEGHDVTVLMTKSATQFITPLTLQVLSKNKVHLDI
CCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEE
MDEERPELVNHIDLAKNTELFLVAPATADTISRLAQGRADDIVTSVALALEPSVPKYFAP
CCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCC
AMNTKMYQHPLTQKNIEILKKIDYNMIQPKKSLLACGDFGEGALADLPDILSDLKNSL
HHCCHHHHCCCCHHHHHHHHHCCCCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKITLAVTGSIAAYKAADLTSLLTKEGHDVTVLMTKSATQFITPLTLQVLSKNKVHLDI
CEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEE
MDEERPELVNHIDLAKNTELFLVAPATADTISRLAQGRADDIVTSVALALEPSVPKYFAP
CCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCC
AMNTKMYQHPLTQKNIEILKKIDYNMIQPKKSLLACGDFGEGALADLPDILSDLKNSL
HHCCHHHHCCCCHHHHHHHHHCCCCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]