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The map label for this gene is pyrG

Identifier: 15672473

GI number: 15672473

Start: 488243

End: 489850

Strand: Direct

Name: pyrG

Synonym: L88252

Alternate gene names: 15672473

Gene position: 488243-489850 (Clockwise)

Preceding gene: 15672472

Following gene: 15672478

Centisome position: 20.64

GC content: 40.11

Gene sequence:

>1608_bases
ATGTCAACTAAGTATATTTTCGTCACTGGTGGTGGTACTTCGTCAATGGGTAAAGGGATCGTAGCGGCATCGCTCGGTCG
TTTGCTTAAAAATCGTGGGCTTAAAGTCACTGTCCAAAAATTTGACCCATACCTTAACATCGACCCAGGGACAATGAGCC
CTTATCAACATGGTGAAGTCTTTGTTACTGATGATGGTGCTGAAACTGACCTTGACCTTGGTCACTATGAACGTTTCATT
GACATCAATTTAAATAAATATTCAAATGTTACTTCCGGTAAAGTTTACAGTGAGATTCTTCGTAAAGAACGTAAGGGAGA
ATATCTCGGAGCAACTGTCCAAATGGTACCGCATGTGACTAACATGTTGAAAGAAAAAATTAAACGTGCAGCAACAACAA
CTGATGCAGATATCATTATCACAGAAGTTGGTGGAACGGTTGGCGATATGGAAAGTTTGCCATTTATTGAAGCTTTACGC
CAAATGAAAGCCGAAGTTGGTGCGGACAACGTCATGTACATTCACACTGTTCCAATTCTTCACTTGCGTGCTGCTGGAGA
ATTGAAAACTAAAATCGCCCAAAATGCGACTAAGACACTTCGTGAATATGGTATCCAAGCTAACATGCTCGTATTACGTA
GTGAAGTTCCAATCACGACAGAAATGCGTGATAAAATTGCGATGTTCTGTGACGTAGCACCAGAAGCAGTCATTCAATCG
CTTGATGTTGAACACTTATACCAAATTCCATTGAACCTTCAAGCACAAAATATGGACCAAATCGTTTGTGACCATTTAAA
ACTTGATGCACCAAAAGCAGATATGACAGAATGGTCAGCAATGGTTGACCATGTCATGAACCTCAAGAAAAAAGTAAAAA
TTGCTTTGGTTGGTAAATATGTAGAATTACCAGATGCTTATATTTCAGTGACTGAAGCGCTTAAACATGCAGGTTATTCA
TCTGATGCCGAAGTTGATATTAACTGGGTTAATGCTAATGATGTAACTGATGAAAATGTTGCTGAACTTGTTGGTGATGC
TGCAGGAATTATTGTTCCTGGAGGATTTGGTCATCGTGGCACAGAAGGTAAGATTGCAGCTATTAAATATGCGCGTGAAA
ATGACGTTCCAATGCTTGGAATCTGTCTTGGAATGCAATTGACAGCAGTTGAATTCGCTCGTAATGTTCTTGGACTTGAA
GGAGCTCATTCATTTGAATTAGACCCTGAAACAAAATATCCAGTCATTGACATTATGCGTGACCAAGTTGATGTTGAAGA
CATGGGTGGAACACTACGTCTTGGACTTTACCCAGCTAAATTGAAAAATGGCTCACGCGCTAAAGCAGCCTACAATGATG
CTGAAGTGGTTCAACGTCGCCACCGTCACCGTTATGAATTCAATAACAAATTCCGCGAAGACTTTGAAAAAGCTGGTTTC
GTATTCTCAGGCGTTTCACCAGATAACCGTTTGGTTGAAATCGTTGAACTTTCTGATAAAAAATTCTTCGTGGCATGTCA
ATATCACCCAGAATTGCAATCACGTCCAAACCGTCCAGAAGAACTCTACACAGAATTTATTCGTGTAGCGGTTGAAAATA
GTAAATAA

Upstream 100 bases:

>100_bases
TTTTATTATAAAAAATCAGTACCGGTAGGCTCCCCTCTGGGGAGCTGTTTTTGTTTTTCCCAGTTATTTCTGTTTTGTAA
AAAGATTAGAGGAGATTTAG

Downstream 100 bases:

>100_bases
TATAGGCTAAAAAACCTCCGAGATTAGGAGGTTTTTTATTTGTTTTAAATAATCAGAATATTTAAACATAGCTTGTTTTC
CCATACTTTTTGTATTATAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSTKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFI
DINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVTNMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALR
QMKAEVGADNVMYIHTVPILHLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQS
LDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMTEWSAMVDHVMNLKKKVKIALVGKYVELPDAYISVTEALKHAGYS
SDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGHRGTEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLE
GAHSFELDPETKYPVIDIMRDQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKFREDFEKAGF
VFSGVSPDNRLVEIVELSDKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK

Sequences:

>Translated_535_residues
MSTKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFI
DINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVTNMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALR
QMKAEVGADNVMYIHTVPILHLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQS
LDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMTEWSAMVDHVMNLKKKVKIALVGKYVELPDAYISVTEALKHAGYS
SDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGHRGTEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLE
GAHSFELDPETKYPVIDIMRDQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKFREDFEKAGF
VFSGVSPDNRLVEIVELSDKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK
>Mature_534_residues
STKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVTNMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALRQ
MKAEVGADNVMYIHTVPILHLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQSL
DVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMTEWSAMVDHVMNLKKKVKIALVGKYVELPDAYISVTEALKHAGYSS
DAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGHRGTEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLEG
AHSFELDPETKYPVIDIMRDQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKFREDFEKAGFV
FSGVSPDNRLVEIVELSDKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=44.464609800363, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=42.1818181818182, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=42.1818181818182, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=42.1818181818182, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=545, Percent_Identity=48.0733944954128, Blast_Score=526, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI25148299, Length=589, Percent_Identity=37.8607809847199, Blast_Score=399, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319432, Length=556, Percent_Identity=44.2446043165468, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322563, Length=553, Percent_Identity=44.8462929475588, Blast_Score=455, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24664469, Length=549, Percent_Identity=41.8943533697632, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21357815, Length=494, Percent_Identity=39.4736842105263, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_LACLA (Q9CI75)

Other databases:

- EMBL:   AE005176
- PIR:   C86686
- RefSeq:   NP_266647.1
- ProteinModelPortal:   Q9CI75
- SMR:   Q9CI75
- GeneID:   1114109
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L88252
- NMPDR:   fig|272623.1.peg.506
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   LLAC272623:L88252-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59553; Mature: 59422

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 382-382 ACT_SITE 509-509 ACT_SITE 511-511

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVT
EEECCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALRQMKAEVGADNVMYIHTVPIL
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECEE
HLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQS
EEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHH
LDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMTEWSAMVDHVMNLKKKVKIALVGKY
CCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECH
VELPDAYISVTEALKHAGYSSDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGHRG
HHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCC
TEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLEGAHSFELDPETKYPVIDIMR
CCCCEEEEEEECCCCCCEEEEHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
DQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKFREDFEKAGF
CCCCHHHCCCEEEEEEEHHHCCCCCCCHHCCCHHHHHHHHHHHCCHHCHHHHHHHHHCCE
VFSGVSPDNRLVEIVELSDKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK
EEECCCCCCCEEEEEEECCCEEEEEEEECCHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEV
CCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVT
EEECCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALRQMKAEVGADNVMYIHTVPIL
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECEE
HLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQS
EEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHH
LDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMTEWSAMVDHVMNLKKKVKIALVGKY
CCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECH
VELPDAYISVTEALKHAGYSSDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGHRG
HHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCC
TEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLEGAHSFELDPETKYPVIDIMR
CCCCEEEEEEECCCCCCEEEEHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
DQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKFREDFEKAGF
CCCCHHHCCCEEEEEEEHHHCCCCCCCHHCCCHHHHHHHHHHHCCHHCHHHHHHHHHCCE
VFSGVSPDNRLVEIVELSDKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK
EEECCCCCCCEEEEEEECCCEEEEEEEECCHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471